Summary | |
---|---|
Symbol | RELA |
Name | v-rel avian reticuloendotheliosis viral oncogene homolog A |
Aliases | NFKB3; nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; NF-kappa-B p65delta3; NF-kappa- ...... |
Chromosomal Location | 11q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus. Cytoplasm. Note=Colocalized with DDX1 in the nucleus upon TNF-alpha induction (By similarity). Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B). Colocalizes with GFI1 in the nucleus after LPS stimulation. |
Domain |
PF16179 Rel homology dimerisation domain PF00554 Rel homology DNA-binding domain |
Function |
NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681). |
Biological Process |
GO:0000302 response to reactive oxygen species GO:0001101 response to acid chemical GO:0001501 skeletal system development GO:0001819 positive regulation of cytokine production GO:0001889 liver development GO:0001942 hair follicle development GO:0002062 chondrocyte differentiation GO:0002218 activation of innate immune response GO:0002220 innate immune response activating cell surface receptor signaling pathway GO:0002221 pattern recognition receptor signaling pathway GO:0002223 stimulatory C-type lectin receptor signaling pathway GO:0002237 response to molecule of bacterial origin GO:0002429 immune response-activating cell surface receptor signaling pathway GO:0002753 cytoplasmic pattern recognition receptor signaling pathway GO:0002757 immune response-activating signal transduction GO:0002758 innate immune response-activating signal transduction GO:0002764 immune response-regulating signaling pathway GO:0002768 immune response-regulating cell surface receptor signaling pathway GO:0006081 cellular aldehyde metabolic process GO:0006117 acetaldehyde metabolic process GO:0006968 cellular defense response GO:0006979 response to oxidative stress GO:0007249 I-kappaB kinase/NF-kappaB signaling GO:0007422 peripheral nervous system development GO:0007568 aging GO:0007584 response to nutrient GO:0008286 insulin receptor signaling pathway GO:0008544 epidermis development GO:0009314 response to radiation GO:0009411 response to UV GO:0009416 response to light stimulus GO:0009612 response to mechanical stimulus GO:0009615 response to virus GO:0009894 regulation of catabolic process GO:0009895 negative regulation of catabolic process GO:0009991 response to extracellular stimulus GO:0010001 glial cell differentiation GO:0010035 response to inorganic substance GO:0010224 response to UV-B GO:0010586 miRNA metabolic process GO:0010720 positive regulation of cell development GO:0014013 regulation of gliogenesis GO:0014015 positive regulation of gliogenesis GO:0014037 Schwann cell differentiation GO:0014038 regulation of Schwann cell differentiation GO:0014040 positive regulation of Schwann cell differentiation GO:0014072 response to isoquinoline alkaloid GO:0014074 response to purine-containing compound GO:0022404 molting cycle process GO:0022405 hair cycle process GO:0030522 intracellular receptor signaling pathway GO:0031293 membrane protein intracellular domain proteolysis GO:0031349 positive regulation of defense response GO:0031667 response to nutrient levels GO:0032330 regulation of chondrocyte differentiation GO:0032332 positive regulation of chondrocyte differentiation GO:0032479 regulation of type I interferon production GO:0032481 positive regulation of type I interferon production GO:0032495 response to muramyl dipeptide GO:0032496 response to lipopolysaccharide GO:0032570 response to progesterone GO:0032606 type I interferon production GO:0032615 interleukin-12 production GO:0032655 regulation of interleukin-12 production GO:0032735 positive regulation of interleukin-12 production GO:0032868 response to insulin GO:0032869 cellular response to insulin stimulus GO:0033273 response to vitamin GO:0033590 response to cobalamin GO:0033619 membrane protein proteolysis GO:0034599 cellular response to oxidative stress GO:0034612 response to tumor necrosis factor GO:0034614 cellular response to reactive oxygen species GO:0035094 response to nicotine GO:0035728 response to hepatocyte growth factor GO:0035729 cellular response to hepatocyte growth factor stimulus GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway GO:0035994 response to muscle stretch GO:0038061 NIK/NF-kappaB signaling GO:0038093 Fc receptor signaling pathway GO:0038095 Fc-epsilon receptor signaling pathway GO:0042035 regulation of cytokine biosynthetic process GO:0042063 gliogenesis GO:0042089 cytokine biosynthetic process GO:0042090 interleukin-12 biosynthetic process GO:0042107 cytokine metabolic process GO:0042108 positive regulation of cytokine biosynthetic process GO:0042176 regulation of protein catabolic process GO:0042177 negative regulation of protein catabolic process GO:0042303 molting cycle GO:0042493 response to drug GO:0042542 response to hydrogen peroxide GO:0042633 hair cycle GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043200 response to amino acid GO:0043278 response to morphine GO:0043279 response to alkaloid GO:0043434 response to peptide hormone GO:0043588 skin development GO:0045075 regulation of interleukin-12 biosynthetic process GO:0045084 positive regulation of interleukin-12 biosynthetic process GO:0045088 regulation of innate immune response GO:0045089 positive regulation of innate immune response GO:0045685 regulation of glial cell differentiation GO:0045687 positive regulation of glial cell differentiation GO:0046626 regulation of insulin receptor signaling pathway GO:0046627 negative regulation of insulin receptor signaling pathway GO:0046683 response to organophosphorus GO:0048545 response to steroid hormone GO:0048732 gland development GO:0050727 regulation of inflammatory response GO:0050769 positive regulation of neurogenesis GO:0050851 antigen receptor-mediated signaling pathway GO:0050852 T cell receptor signaling pathway GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051092 positive regulation of NF-kappaB transcription factor activity GO:0051216 cartilage development GO:0051591 response to cAMP GO:0051607 defense response to virus GO:0051962 positive regulation of nervous system development GO:0061008 hepaticobiliary system development GO:0061035 regulation of cartilage development GO:0061036 positive regulation of cartilage development GO:0061448 connective tissue development GO:0061614 pri-miRNA transcription from RNA polymerase II promoter GO:0070301 cellular response to hydrogen peroxide GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway GO:0070555 response to interleukin-1 GO:0070741 response to interleukin-6 GO:0071216 cellular response to biotic stimulus GO:0071219 cellular response to molecule of bacterial origin GO:0071222 cellular response to lipopolysaccharide GO:0071312 cellular response to alkaloid GO:0071316 cellular response to nicotine GO:0071347 cellular response to interleukin-1 GO:0071354 cellular response to interleukin-6 GO:0071356 cellular response to tumor necrosis factor GO:0071375 cellular response to peptide hormone stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0071417 cellular response to organonitrogen compound GO:0097191 extrinsic apoptotic signaling pathway GO:0098542 defense response to other organism GO:0098773 skin epidermis development GO:1900076 regulation of cellular response to insulin stimulus GO:1900077 negative regulation of cellular response to insulin stimulus GO:1901222 regulation of NIK/NF-kappaB signaling GO:1901223 negative regulation of NIK/NF-kappaB signaling GO:1901652 response to peptide GO:1901653 cellular response to peptide GO:1901654 response to ketone GO:1902532 negative regulation of intracellular signal transduction GO:1902893 regulation of pri-miRNA transcription from RNA polymerase II promoter GO:1902895 positive regulation of pri-miRNA transcription from RNA polymerase II promoter GO:1990267 response to transition metal nanoparticle GO:2000628 regulation of miRNA metabolic process GO:2000630 positive regulation of miRNA metabolic process GO:2001233 regulation of apoptotic signaling pathway GO:2001234 negative regulation of apoptotic signaling pathway GO:2001236 regulation of extrinsic apoptotic signaling pathway GO:2001237 negative regulation of extrinsic apoptotic signaling pathway |
Molecular Function |
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001158 enhancer sequence-specific DNA binding GO:0001159 core promoter proximal region DNA binding GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003682 chromatin binding GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0008134 transcription factor binding GO:0031490 chromatin DNA binding GO:0031625 ubiquitin protein ligase binding GO:0033613 activating transcription factor binding GO:0035326 enhancer binding GO:0042301 phosphate ion binding GO:0042805 actinin binding GO:0042826 histone deacetylase binding GO:0043168 anion binding GO:0043566 structure-specific DNA binding GO:0044389 ubiquitin-like protein ligase binding GO:0046982 protein heterodimerization activity GO:0047485 protein N-terminus binding GO:0051059 NF-kappaB binding GO:0070491 repressing transcription factor binding GO:0071532 ankyrin repeat binding |
Cellular Component |
GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0005667 transcription factor complex GO:0033256 I-kappaB/NF-kappaB complex GO:0044454 nuclear chromosome part GO:0071159 NF-kappaB complex |
KEGG |
hsa04010 MAPK signaling pathway hsa04014 Ras signaling pathway hsa04024 cAMP signaling pathway hsa04062 Chemokine signaling pathway hsa04064 NF-kappa B signaling pathway hsa04066 HIF-1 signaling pathway hsa04071 Sphingolipid signaling pathway hsa04151 PI3K-Akt signaling pathway hsa04210 Apoptosis hsa04380 Osteoclast differentiation hsa04620 Toll-like receptor signaling pathway hsa04621 NOD-like receptor signaling pathway hsa04622 RIG-I-like receptor signaling pathway hsa04623 Cytosolic DNA-sensing pathway hsa04660 T cell receptor signaling pathway hsa04662 B cell receptor signaling pathway hsa04668 TNF signaling pathway hsa04722 Neurotrophin signaling pathway hsa04917 Prolactin signaling pathway hsa04920 Adipocytokine signaling pathway |
Reactome |
R-HSA-166054: Activated TLR4 signalling R-HSA-1169091: Activation of NF-kappaB in B cells R-HSA-1280218: Adaptive Immune System R-HSA-5621481: C-type lectin receptors (CLRs) R-HSA-5621575: CD209 (DC-SIGN) signaling R-HSA-5607764: CLEC7A (Dectin-1) signaling R-HSA-5660668: CLEC7A/inflammasome pathway R-HSA-2559583: Cellular Senescence R-HSA-2262752: Cellular responses to stress R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-1834949: Cytosolic sensors of pathogen-associated DNA R-HSA-3134963: DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-5607761: Dectin-1 mediated noncanonical NF-kB signaling R-HSA-1266738: Developmental Biology R-HSA-1643685: Disease R-HSA-5602358: Diseases associated with the TLR signaling cascade R-HSA-5260271: Diseases of Immune System R-HSA-202424: Downstream TCR signaling R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR) R-HSA-2871837: FCERI mediated NF-kB activation R-HSA-2454202: Fc epsilon receptor (FCERI) signaling R-HSA-5603027: IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603029: IkBA variant leads to EDA-ID R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-448706: Interleukin-1 processing R-HSA-975871: MyD88 cascade initiated on plasma membrane R-HSA-975155: MyD88 dependent cascade initiated on endosome R-HSA-166166: MyD88-independent TLR3/TLR4 cascade R-HSA-166058: MyD88 R-HSA-209560: NF-kB is activated and signals survival R-HSA-3214841: PKMTs methylate histone lysines R-HSA-168928: RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways R-HSA-1810476: RIP-mediated NFkB activation via ZBP1 R-HSA-193692: Regulated proteolysis of p75NTR R-HSA-2559582: Senescence-Associated Secretory Phenotype (SASP) R-HSA-162582: Signal Transduction R-HSA-449147: Signaling by Interleukins R-HSA-983705: Signaling by the B Cell Receptor (BCR) R-HSA-166520: Signalling by NGF R-HSA-445989: TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-HSA-202403: TCR signaling R-HSA-168180: TRAF6 Mediated Induction of proinflammatory cytokines R-HSA-933542: TRAF6 mediated NF-kB activation R-HSA-975138: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-937061: TRIF-mediated TLR3/TLR4 signaling R-HSA-168142: Toll Like Receptor 10 (TLR10) Cascade R-HSA-181438: Toll Like Receptor 2 (TLR2) Cascade R-HSA-168164: Toll Like Receptor 3 (TLR3) Cascade R-HSA-166016: Toll Like Receptor 4 (TLR4) Cascade R-HSA-168176: Toll Like Receptor 5 (TLR5) Cascade R-HSA-168181: Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168138: Toll Like Receptor 9 (TLR9) Cascade R-HSA-168179: Toll Like Receptor TLR1 R-HSA-168188: Toll Like Receptor TLR6 R-HSA-168898: Toll-Like Receptors Cascades R-HSA-381340: Transcriptional regulation of white adipocyte differentiation R-HSA-1606322: ZBP1(DAI) mediated induction of type I IFNs R-HSA-193704: p75 NTR receptor-mediated signalling R-HSA-193639: p75NTR signals via NF-kB |
Summary | |
---|---|
Symbol | RELA |
Name | v-rel avian reticuloendotheliosis viral oncogene homolog A |
Aliases | NFKB3; nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; NF-kappa-B p65delta3; NF-kappa- ...... |
Chromosomal Location | 11q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between RELA and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between RELA and anti-tumor immunity in human cancer.
|
Summary | |
---|---|
Symbol | RELA |
Name | v-rel avian reticuloendotheliosis viral oncogene homolog A |
Aliases | NFKB3; nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; NF-kappa-B p65delta3; NF-kappa- ...... |
Chromosomal Location | 11q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of RELA in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | RELA |
Name | v-rel avian reticuloendotheliosis viral oncogene homolog A |
Aliases | NFKB3; nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; NF-kappa-B p65delta3; NF-kappa- ...... |
Chromosomal Location | 11q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of RELA in various data sets.
|
Points in the above scatter plot represent the mutation difference of RELA in various data sets.
|
Summary | |
---|---|
Symbol | RELA |
Name | v-rel avian reticuloendotheliosis viral oncogene homolog A |
Aliases | NFKB3; nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; NF-kappa-B p65delta3; NF-kappa- ...... |
Chromosomal Location | 11q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RELA. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | RELA |
Name | v-rel avian reticuloendotheliosis viral oncogene homolog A |
Aliases | NFKB3; nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; NF-kappa-B p65delta3; NF-kappa- ...... |
Chromosomal Location | 11q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RELA. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RELA. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | RELA |
Name | v-rel avian reticuloendotheliosis viral oncogene homolog A |
Aliases | NFKB3; nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; NF-kappa-B p65delta3; NF-kappa- ...... |
Chromosomal Location | 11q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RELA. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | RELA |
Name | v-rel avian reticuloendotheliosis viral oncogene homolog A |
Aliases | NFKB3; nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; NF-kappa-B p65delta3; NF-kappa- ...... |
Chromosomal Location | 11q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of RELA expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | RELA |
Name | v-rel avian reticuloendotheliosis viral oncogene homolog A |
Aliases | NFKB3; nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; NF-kappa-B p65delta3; NF-kappa- ...... |
Chromosomal Location | 11q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between RELA and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | RELA |
Name | v-rel avian reticuloendotheliosis viral oncogene homolog A |
Aliases | NFKB3; nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; NF-kappa-B p65delta3; NF-kappa- ...... |
Chromosomal Location | 11q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting RELA collected from DrugBank database. |
Details on drugs targeting RELA.
|