Summary | |
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Symbol | RGCC |
Name | regulator of cell cycle |
Aliases | bA157L14.2; RGC-32; RGC32; response gene to complement 32; C13orf15; chromosome 13 open reading frame 15; re ...... |
Chromosomal Location | 13q14.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic in unstimulated cells. Nuclear after activation by complement. Associated with the centrosome during prometaphase and metaphase. |
Domain |
PF15151 Response gene to complement 32 protein family |
Function |
Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation. |
Biological Process |
GO:0000075 cell cycle checkpoint GO:0000077 DNA damage checkpoint GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity GO:0000082 G1/S transition of mitotic cell cycle GO:0001100 negative regulation of exit from mitosis GO:0001525 angiogenesis GO:0001666 response to hypoxia GO:0001667 ameboidal-type cell migration GO:0001818 negative regulation of cytokine production GO:0001819 positive regulation of cytokine production GO:0001837 epithelial to mesenchymal transition GO:0001935 endothelial cell proliferation GO:0001936 regulation of endothelial cell proliferation GO:0001937 negative regulation of endothelial cell proliferation GO:0003330 regulation of extracellular matrix constituent secretion GO:0003331 positive regulation of extracellular matrix constituent secretion GO:0006956 complement activation GO:0006959 humoral immune response GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0007015 actin filament organization GO:0007050 cell cycle arrest GO:0007067 mitotic nuclear division GO:0007088 regulation of mitotic nuclear division GO:0007093 mitotic cell cycle checkpoint GO:0007096 regulation of exit from mitosis GO:0007162 negative regulation of cell adhesion GO:0007346 regulation of mitotic cell cycle GO:0009306 protein secretion GO:0010458 exit from mitosis GO:0010594 regulation of endothelial cell migration GO:0010596 negative regulation of endothelial cell migration GO:0010631 epithelial cell migration GO:0010632 regulation of epithelial cell migration GO:0010633 negative regulation of epithelial cell migration GO:0010639 negative regulation of organelle organization GO:0010712 regulation of collagen metabolic process GO:0010714 positive regulation of collagen metabolic process GO:0010717 regulation of epithelial to mesenchymal transition GO:0010718 positive regulation of epithelial to mesenchymal transition GO:0010948 negative regulation of cell cycle process GO:0016525 negative regulation of angiogenesis GO:0022407 regulation of cell-cell adhesion GO:0022408 negative regulation of cell-cell adhesion GO:0030038 contractile actin filament bundle assembly GO:0030198 extracellular matrix organization GO:0030330 DNA damage response, signal transduction by p53 class mediator GO:0030336 negative regulation of cell migration GO:0031032 actomyosin structure organization GO:0031570 DNA integrity checkpoint GO:0031571 mitotic G1 DNA damage checkpoint GO:0031657 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031659 positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0032147 activation of protein kinase activity GO:0032231 regulation of actin filament bundle assembly GO:0032233 positive regulation of actin filament bundle assembly GO:0032956 regulation of actin cytoskeleton organization GO:0032963 collagen metabolic process GO:0032964 collagen biosynthetic process GO:0032965 regulation of collagen biosynthetic process GO:0032967 positive regulation of collagen biosynthetic process GO:0032970 regulation of actin filament-based process GO:0033674 positive regulation of kinase activity GO:0036293 response to decreased oxygen levels GO:0036294 cellular response to decreased oxygen levels GO:0040013 negative regulation of locomotion GO:0042770 signal transduction in response to DNA damage GO:0043062 extracellular structure organization GO:0043149 stress fiber assembly GO:0043534 blood vessel endothelial cell migration GO:0043535 regulation of blood vessel endothelial cell migration GO:0043537 negative regulation of blood vessel endothelial cell migration GO:0043542 endothelial cell migration GO:0044089 positive regulation of cellular component biogenesis GO:0044236 multicellular organism metabolic process GO:0044246 regulation of multicellular organismal metabolic process GO:0044253 positive regulation of multicellular organismal metabolic process GO:0044259 multicellular organismal macromolecule metabolic process GO:0044331 cell-cell adhesion mediated by cadherin GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0044773 mitotic DNA damage checkpoint GO:0044774 mitotic DNA integrity checkpoint GO:0044783 G1 DNA damage checkpoint GO:0044819 mitotic G1/S transition checkpoint GO:0044843 cell cycle G1/S phase transition GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045765 regulation of angiogenesis GO:0045786 negative regulation of cell cycle GO:0045787 positive regulation of cell cycle GO:0045839 negative regulation of mitotic nuclear division GO:0045840 positive regulation of mitotic nuclear division GO:0045860 positive regulation of protein kinase activity GO:0045930 negative regulation of mitotic cell cycle GO:0045931 positive regulation of mitotic cell cycle GO:0048514 blood vessel morphogenesis GO:0048762 mesenchymal cell differentiation GO:0050663 cytokine secretion GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0050680 negative regulation of epithelial cell proliferation GO:0050707 regulation of cytokine secretion GO:0050708 regulation of protein secretion GO:0050709 negative regulation of protein secretion GO:0050710 negative regulation of cytokine secretion GO:0050714 positive regulation of protein secretion GO:0050715 positive regulation of cytokine secretion GO:0051017 actin filament bundle assembly GO:0051047 positive regulation of secretion GO:0051048 negative regulation of secretion GO:0051051 negative regulation of transport GO:0051052 regulation of DNA metabolic process GO:0051054 positive regulation of DNA metabolic process GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051222 positive regulation of protein transport GO:0051224 negative regulation of protein transport GO:0051271 negative regulation of cellular component movement GO:0051492 regulation of stress fiber assembly GO:0051493 regulation of cytoskeleton organization GO:0051495 positive regulation of cytoskeleton organization GO:0051496 positive regulation of stress fiber assembly GO:0051783 regulation of nuclear division GO:0051784 negative regulation of nuclear division GO:0051785 positive regulation of nuclear division GO:0060485 mesenchyme development GO:0061572 actin filament bundle organization GO:0070278 extracellular matrix constituent secretion GO:0070482 response to oxygen levels GO:0071156 regulation of cell cycle arrest GO:0071158 positive regulation of cell cycle arrest GO:0071453 cellular response to oxygen levels GO:0071456 cellular response to hypoxia GO:0071850 mitotic cell cycle arrest GO:0071897 DNA biosynthetic process GO:0071900 regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity GO:0072331 signal transduction by p53 class mediator GO:0072376 protein activation cascade GO:0072395 signal transduction involved in cell cycle checkpoint GO:0072401 signal transduction involved in DNA integrity checkpoint GO:0072413 signal transduction involved in mitotic cell cycle checkpoint GO:0072422 signal transduction involved in DNA damage checkpoint GO:0072431 signal transduction involved in mitotic G1 DNA damage checkpoint GO:0072537 fibroblast activation GO:0072577 endothelial cell apoptotic process GO:0085029 extracellular matrix assembly GO:0090068 positive regulation of cell cycle process GO:0090130 tissue migration GO:0090132 epithelium migration GO:0090269 fibroblast growth factor production GO:0090270 regulation of fibroblast growth factor production GO:0090272 negative regulation of fibroblast growth factor production GO:1901201 regulation of extracellular matrix assembly GO:1901203 positive regulation of extracellular matrix assembly GO:1901342 regulation of vasculature development GO:1901343 negative regulation of vasculature development GO:1901987 regulation of cell cycle phase transition GO:1901988 negative regulation of cell cycle phase transition GO:1901990 regulation of mitotic cell cycle phase transition GO:1901991 negative regulation of mitotic cell cycle phase transition GO:1902400 intracellular signal transduction involved in G1 DNA damage checkpoint GO:1902402 signal transduction involved in mitotic DNA damage checkpoint GO:1902403 signal transduction involved in mitotic DNA integrity checkpoint GO:1902806 regulation of cell cycle G1/S phase transition GO:1902807 negative regulation of cell cycle G1/S phase transition GO:1903053 regulation of extracellular matrix organization GO:1903055 positive regulation of extracellular matrix organization GO:1903531 negative regulation of secretion by cell GO:1903532 positive regulation of secretion by cell GO:1904019 epithelial cell apoptotic process GO:1904029 regulation of cyclin-dependent protein kinase activity GO:1904031 positive regulation of cyclin-dependent protein kinase activity GO:1904035 regulation of epithelial cell apoptotic process GO:1904037 positive regulation of epithelial cell apoptotic process GO:1904950 negative regulation of establishment of protein localization GO:1904951 positive regulation of establishment of protein localization GO:2000045 regulation of G1/S transition of mitotic cell cycle GO:2000047 regulation of cell-cell adhesion mediated by cadherin GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin GO:2000134 negative regulation of G1/S transition of mitotic cell cycle GO:2000146 negative regulation of cell motility GO:2000181 negative regulation of blood vessel morphogenesis GO:2000278 regulation of DNA biosynthetic process GO:2000351 regulation of endothelial cell apoptotic process GO:2000353 positive regulation of endothelial cell apoptotic process GO:2000573 positive regulation of DNA biosynthetic process |
Molecular Function |
GO:0008047 enzyme activator activity GO:0019207 kinase regulator activity GO:0019209 kinase activator activity GO:0019887 protein kinase regulator activity GO:0030295 protein kinase activator activity GO:0046332 SMAD binding GO:0070412 R-SMAD binding |
Cellular Component |
GO:0005813 centrosome |
KEGG | - |
Reactome |
R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-6791312: TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6804115: TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-3700989: Transcriptional Regulation by TP53 |
Summary | |
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Symbol | RGCC |
Name | regulator of cell cycle |
Aliases | bA157L14.2; RGC-32; RGC32; response gene to complement 32; C13orf15; chromosome 13 open reading frame 15; re ...... |
Chromosomal Location | 13q14.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between RGCC and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | RGCC |
Name | regulator of cell cycle |
Aliases | bA157L14.2; RGC-32; RGC32; response gene to complement 32; C13orf15; chromosome 13 open reading frame 15; re ...... |
Chromosomal Location | 13q14.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of RGCC in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | RGCC |
Name | regulator of cell cycle |
Aliases | bA157L14.2; RGC-32; RGC32; response gene to complement 32; C13orf15; chromosome 13 open reading frame 15; re ...... |
Chromosomal Location | 13q14.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of RGCC in various data sets.
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Points in the above scatter plot represent the mutation difference of RGCC in various data sets.
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Summary | |
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Symbol | RGCC |
Name | regulator of cell cycle |
Aliases | bA157L14.2; RGC-32; RGC32; response gene to complement 32; C13orf15; chromosome 13 open reading frame 15; re ...... |
Chromosomal Location | 13q14.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RGCC. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | RGCC |
Name | regulator of cell cycle |
Aliases | bA157L14.2; RGC-32; RGC32; response gene to complement 32; C13orf15; chromosome 13 open reading frame 15; re ...... |
Chromosomal Location | 13q14.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RGCC. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RGCC. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | RGCC |
Name | regulator of cell cycle |
Aliases | bA157L14.2; RGC-32; RGC32; response gene to complement 32; C13orf15; chromosome 13 open reading frame 15; re ...... |
Chromosomal Location | 13q14.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RGCC. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | RGCC |
Name | regulator of cell cycle |
Aliases | bA157L14.2; RGC-32; RGC32; response gene to complement 32; C13orf15; chromosome 13 open reading frame 15; re ...... |
Chromosomal Location | 13q14.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of RGCC expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | RGCC |
Name | regulator of cell cycle |
Aliases | bA157L14.2; RGC-32; RGC32; response gene to complement 32; C13orf15; chromosome 13 open reading frame 15; re ...... |
Chromosomal Location | 13q14.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between RGCC and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | RGCC |
Name | regulator of cell cycle |
Aliases | bA157L14.2; RGC-32; RGC32; response gene to complement 32; C13orf15; chromosome 13 open reading frame 15; re ...... |
Chromosomal Location | 13q14.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting RGCC collected from DrugBank database. |
There is no record. |