Summary | |
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Symbol | RGL1 |
Name | ral guanine nucleotide dissociation stimulator-like 1 |
Aliases | RGL; ralGDS-like 1 |
Chromosomal Location | 1q25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF00788 Ras association (RalGDS/AF-6) domain PF00617 RasGEF domain PF00618 RasGEF N-terminal motif |
Function |
Probable guanine nucleotide exchange factor. |
Biological Process | - |
Molecular Function |
GO:0005085 guanyl-nucleotide exchange factor activity GO:0005088 Ras guanyl-nucleotide exchange factor activity GO:0008321 Ral guanyl-nucleotide exchange factor activity |
Cellular Component | - |
KEGG |
hsa04014 Ras signaling pathway |
Reactome |
R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-1989781: PPARA activates gene expression R-HSA-400206: Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |
Summary | |
---|---|
Symbol | RGL1 |
Name | ral guanine nucleotide dissociation stimulator-like 1 |
Aliases | RGL; ralGDS-like 1 |
Chromosomal Location | 1q25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between RGL1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | RGL1 |
Name | ral guanine nucleotide dissociation stimulator-like 1 |
Aliases | RGL; ralGDS-like 1 |
Chromosomal Location | 1q25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of RGL1 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | RGL1 |
Name | ral guanine nucleotide dissociation stimulator-like 1 |
Aliases | RGL; ralGDS-like 1 |
Chromosomal Location | 1q25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of RGL1 in various data sets.
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Points in the above scatter plot represent the mutation difference of RGL1 in various data sets.
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Summary | |
---|---|
Symbol | RGL1 |
Name | ral guanine nucleotide dissociation stimulator-like 1 |
Aliases | RGL; ralGDS-like 1 |
Chromosomal Location | 1q25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RGL1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | RGL1 |
Name | ral guanine nucleotide dissociation stimulator-like 1 |
Aliases | RGL; ralGDS-like 1 |
Chromosomal Location | 1q25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RGL1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RGL1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | RGL1 |
Name | ral guanine nucleotide dissociation stimulator-like 1 |
Aliases | RGL; ralGDS-like 1 |
Chromosomal Location | 1q25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RGL1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | RGL1 |
Name | ral guanine nucleotide dissociation stimulator-like 1 |
Aliases | RGL; ralGDS-like 1 |
Chromosomal Location | 1q25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of RGL1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | RGL1 |
Name | ral guanine nucleotide dissociation stimulator-like 1 |
Aliases | RGL; ralGDS-like 1 |
Chromosomal Location | 1q25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between RGL1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |