Summary | |
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Symbol | RGS12 |
Name | regulator of G-protein signaling 12 |
Aliases | regulator of G-protein signalling 12 |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Cytoplasm Cell projection, dendrite Cell junction, synapse ; SUBCELLULAR LOCATION: Isoform 5: Nucleus matrix Note=Also localized to discrete nuclear foci that are distinct from sites of RNA processing, PML nuclear bodies, and PcG domains. |
Domain |
PF02188 GoLoco motif PF00595 PDZ domain (Also known as DHR or GLGF) PF02196 Raf-like Ras-binding domain PF00615 Regulator of G protein signaling domain |
Function |
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. ; FUNCTION: Isoform 5: Behaves as a cell cycle-dependent transcriptional repressor, promoting inhibition of S-phase DNA synthesis. |
Biological Process |
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway |
Molecular Function |
GO:0005057 receptor signaling protein activity GO:0005096 GTPase activator activity GO:0008047 enzyme activator activity GO:0030695 GTPase regulator activity GO:0060589 nucleoside-triphosphatase regulator activity |
Cellular Component |
GO:0000793 condensed chromosome GO:0000794 condensed nuclear chromosome GO:0016363 nuclear matrix GO:0030425 dendrite GO:0034399 nuclear periphery |
KEGG | - |
Reactome |
R-HSA-418594: G alpha (i) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR |
Summary | |
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Symbol | RGS12 |
Name | regulator of G-protein signaling 12 |
Aliases | regulator of G-protein signalling 12 |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between RGS12 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | RGS12 |
Name | regulator of G-protein signaling 12 |
Aliases | regulator of G-protein signalling 12 |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of RGS12 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | RGS12 |
Name | regulator of G-protein signaling 12 |
Aliases | regulator of G-protein signalling 12 |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of RGS12 in various data sets.
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Points in the above scatter plot represent the mutation difference of RGS12 in various data sets.
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Summary | |
---|---|
Symbol | RGS12 |
Name | regulator of G-protein signaling 12 |
Aliases | regulator of G-protein signalling 12 |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RGS12. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | RGS12 |
Name | regulator of G-protein signaling 12 |
Aliases | regulator of G-protein signalling 12 |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RGS12. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RGS12. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | RGS12 |
Name | regulator of G-protein signaling 12 |
Aliases | regulator of G-protein signalling 12 |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RGS12. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | RGS12 |
Name | regulator of G-protein signaling 12 |
Aliases | regulator of G-protein signalling 12 |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of RGS12 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | RGS12 |
Name | regulator of G-protein signaling 12 |
Aliases | regulator of G-protein signalling 12 |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between RGS12 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |