Summary | |
---|---|
Symbol | RGS4 |
Name | regulator of G-protein signaling 4 |
Aliases | regulator of G-protein signalling 4; schizophrenia disorder 9 |
Chromosomal Location | 1q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF00615 Regulator of G protein signaling domain |
Function |
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein. |
Biological Process |
GO:0000188 inactivation of MAPK activity GO:0001933 negative regulation of protein phosphorylation GO:0006469 negative regulation of protein kinase activity GO:0008277 regulation of G-protein coupled receptor protein signaling pathway GO:0033673 negative regulation of kinase activity GO:0042326 negative regulation of phosphorylation GO:0043405 regulation of MAP kinase activity GO:0043407 negative regulation of MAP kinase activity GO:0043409 negative regulation of MAPK cascade GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway GO:0051348 negative regulation of transferase activity GO:0071900 regulation of protein serine/threonine kinase activity GO:0071901 negative regulation of protein serine/threonine kinase activity GO:1902532 negative regulation of intracellular signal transduction |
Molecular Function |
GO:0001965 G-protein alpha-subunit binding GO:0005096 GTPase activator activity GO:0005516 calmodulin binding GO:0008047 enzyme activator activity GO:0030695 GTPase regulator activity GO:0060589 nucleoside-triphosphatase regulator activity |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-418594: G alpha (i) signalling events R-HSA-418597: G alpha (z) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR |
Summary | |
---|---|
Symbol | RGS4 |
Name | regulator of G-protein signaling 4 |
Aliases | regulator of G-protein signalling 4; schizophrenia disorder 9 |
Chromosomal Location | 1q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between RGS4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | RGS4 |
Name | regulator of G-protein signaling 4 |
Aliases | regulator of G-protein signalling 4; schizophrenia disorder 9 |
Chromosomal Location | 1q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of RGS4 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | RGS4 |
Name | regulator of G-protein signaling 4 |
Aliases | regulator of G-protein signalling 4; schizophrenia disorder 9 |
Chromosomal Location | 1q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of RGS4 in various data sets.
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Points in the above scatter plot represent the mutation difference of RGS4 in various data sets.
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Summary | |
---|---|
Symbol | RGS4 |
Name | regulator of G-protein signaling 4 |
Aliases | regulator of G-protein signalling 4; schizophrenia disorder 9 |
Chromosomal Location | 1q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RGS4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | RGS4 |
Name | regulator of G-protein signaling 4 |
Aliases | regulator of G-protein signalling 4; schizophrenia disorder 9 |
Chromosomal Location | 1q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RGS4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RGS4. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | RGS4 |
Name | regulator of G-protein signaling 4 |
Aliases | regulator of G-protein signalling 4; schizophrenia disorder 9 |
Chromosomal Location | 1q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RGS4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | RGS4 |
Name | regulator of G-protein signaling 4 |
Aliases | regulator of G-protein signalling 4; schizophrenia disorder 9 |
Chromosomal Location | 1q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of RGS4 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | RGS4 |
Name | regulator of G-protein signaling 4 |
Aliases | regulator of G-protein signalling 4; schizophrenia disorder 9 |
Chromosomal Location | 1q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between RGS4 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |