Summary | |
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Symbol | RGS9BP |
Name | regulator of G protein signaling 9 binding protein |
Aliases | FLJ45744; R9AP; regulator of G protein signalling 9 binding protein; RGS9 anchor protein; RGS9-anchoring pro ...... |
Chromosomal Location | 19q13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Single-pass type IV membrane protein |
Domain | - |
Function |
Regulator of G protein-coupled receptor (GPCR) signaling in phototransduction. Participates in the recovery phase of visual transduction via its interaction with RGS9-1 isoform. Acts as a membrane-anchor that mediates the targeting of RGS9-1 to the photoreceptor outer segment, where phototransduction takes place. Enhances the ability of RGS9-1 to stimulate G protein GTPase activity, allowing the visual signal to be terminated on the physiologically time scale. It also controls the proteolytic stability of RGS9-1, probably by protecting it from degradation (By similarity). |
Biological Process |
GO:0007601 visual perception GO:0009314 response to radiation GO:0009416 response to light stimulus GO:0009581 detection of external stimulus GO:0009582 detection of abiotic stimulus GO:0009583 detection of light stimulus GO:0009584 detection of visible light GO:0050908 detection of light stimulus involved in visual perception GO:0050953 sensory perception of light stimulus GO:0050962 detection of light stimulus involved in sensory perception |
Molecular Function | - |
Cellular Component |
GO:0001750 photoreceptor outer segment GO:0005929 cilium GO:0031513 nonmotile primary cilium GO:0072372 primary cilium |
KEGG | - |
Reactome |
R-HSA-2514859: Inactivation, recovery and regulation of the phototransduction cascade R-HSA-162582: Signal Transduction R-HSA-2514856: The phototransduction cascade R-HSA-2187338: Visual phototransduction |
Summary | |
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Symbol | RGS9BP |
Name | regulator of G protein signaling 9 binding protein |
Aliases | FLJ45744; R9AP; regulator of G protein signalling 9 binding protein; RGS9 anchor protein; RGS9-anchoring pro ...... |
Chromosomal Location | 19q13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between RGS9BP and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | RGS9BP |
Name | regulator of G protein signaling 9 binding protein |
Aliases | FLJ45744; R9AP; regulator of G protein signalling 9 binding protein; RGS9 anchor protein; RGS9-anchoring pro ...... |
Chromosomal Location | 19q13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of RGS9BP in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | RGS9BP |
Name | regulator of G protein signaling 9 binding protein |
Aliases | FLJ45744; R9AP; regulator of G protein signalling 9 binding protein; RGS9 anchor protein; RGS9-anchoring pro ...... |
Chromosomal Location | 19q13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of RGS9BP in various data sets.
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Points in the above scatter plot represent the mutation difference of RGS9BP in various data sets.
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Summary | |
---|---|
Symbol | RGS9BP |
Name | regulator of G protein signaling 9 binding protein |
Aliases | FLJ45744; R9AP; regulator of G protein signalling 9 binding protein; RGS9 anchor protein; RGS9-anchoring pro ...... |
Chromosomal Location | 19q13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RGS9BP. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | RGS9BP |
Name | regulator of G protein signaling 9 binding protein |
Aliases | FLJ45744; R9AP; regulator of G protein signalling 9 binding protein; RGS9 anchor protein; RGS9-anchoring pro ...... |
Chromosomal Location | 19q13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RGS9BP. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RGS9BP. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | RGS9BP |
Name | regulator of G protein signaling 9 binding protein |
Aliases | FLJ45744; R9AP; regulator of G protein signalling 9 binding protein; RGS9 anchor protein; RGS9-anchoring pro ...... |
Chromosomal Location | 19q13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RGS9BP. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | RGS9BP |
Name | regulator of G protein signaling 9 binding protein |
Aliases | FLJ45744; R9AP; regulator of G protein signalling 9 binding protein; RGS9 anchor protein; RGS9-anchoring pro ...... |
Chromosomal Location | 19q13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of RGS9BP expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | RGS9BP |
Name | regulator of G protein signaling 9 binding protein |
Aliases | FLJ45744; R9AP; regulator of G protein signalling 9 binding protein; RGS9 anchor protein; RGS9-anchoring pro ...... |
Chromosomal Location | 19q13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between RGS9BP and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | RGS9BP |
Name | regulator of G protein signaling 9 binding protein |
Aliases | FLJ45744; R9AP; regulator of G protein signalling 9 binding protein; RGS9 anchor protein; RGS9-anchoring pro ...... |
Chromosomal Location | 19q13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting RGS9BP collected from DrugBank database. |
There is no record. |