Browse RGS9BP

Summary
SymbolRGS9BP
Nameregulator of G protein signaling 9 binding protein
Aliases FLJ45744; R9AP; regulator of G protein signalling 9 binding protein; RGS9 anchor protein; RGS9-anchoring pro ......
Chromosomal Location19q13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Membrane Single-pass type IV membrane protein
Domain -
Function

Regulator of G protein-coupled receptor (GPCR) signaling in phototransduction. Participates in the recovery phase of visual transduction via its interaction with RGS9-1 isoform. Acts as a membrane-anchor that mediates the targeting of RGS9-1 to the photoreceptor outer segment, where phototransduction takes place. Enhances the ability of RGS9-1 to stimulate G protein GTPase activity, allowing the visual signal to be terminated on the physiologically time scale. It also controls the proteolytic stability of RGS9-1, probably by protecting it from degradation (By similarity).

> Gene Ontology
 
Biological Process GO:0007601 visual perception
GO:0009314 response to radiation
GO:0009416 response to light stimulus
GO:0009581 detection of external stimulus
GO:0009582 detection of abiotic stimulus
GO:0009583 detection of light stimulus
GO:0009584 detection of visible light
GO:0050908 detection of light stimulus involved in visual perception
GO:0050953 sensory perception of light stimulus
GO:0050962 detection of light stimulus involved in sensory perception
Molecular Function -
Cellular Component GO:0001750 photoreceptor outer segment
GO:0005929 cilium
GO:0031513 nonmotile primary cilium
GO:0072372 primary cilium
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-2514859: Inactivation, recovery and regulation of the phototransduction cascade
R-HSA-162582: Signal Transduction
R-HSA-2514856: The phototransduction cascade
R-HSA-2187338: Visual phototransduction
Summary
SymbolRGS9BP
Nameregulator of G protein signaling 9 binding protein
Aliases FLJ45744; R9AP; regulator of G protein signalling 9 binding protein; RGS9 anchor protein; RGS9-anchoring pro ......
Chromosomal Location19q13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between RGS9BP and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolRGS9BP
Nameregulator of G protein signaling 9 binding protein
Aliases FLJ45744; R9AP; regulator of G protein signalling 9 binding protein; RGS9 anchor protein; RGS9-anchoring pro ......
Chromosomal Location19q13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of RGS9BP in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolRGS9BP
Nameregulator of G protein signaling 9 binding protein
Aliases FLJ45744; R9AP; regulator of G protein signalling 9 binding protein; RGS9 anchor protein; RGS9-anchoring pro ......
Chromosomal Location19q13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of RGS9BP in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.1390.619
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.1840.716
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.110.792
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9161.540.118
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 591.6280.28
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 471.4390.386
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.2580.695
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.3440.743
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.070.953
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.1160.776
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.1160.851
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.890.00145
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of RGS9BP in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11139.109.10.458
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 512200200.294
Summary
SymbolRGS9BP
Nameregulator of G protein signaling 9 binding protein
Aliases FLJ45744; R9AP; regulator of G protein signalling 9 binding protein; RGS9 anchor protein; RGS9-anchoring pro ......
Chromosomal Location19q13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RGS9BP. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolRGS9BP
Nameregulator of G protein signaling 9 binding protein
Aliases FLJ45744; R9AP; regulator of G protein signalling 9 binding protein; RGS9 anchor protein; RGS9-anchoring pro ......
Chromosomal Location19q13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RGS9BP. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RGS9BP.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolRGS9BP
Nameregulator of G protein signaling 9 binding protein
Aliases FLJ45744; R9AP; regulator of G protein signalling 9 binding protein; RGS9 anchor protein; RGS9-anchoring pro ......
Chromosomal Location19q13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RGS9BP. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolRGS9BP
Nameregulator of G protein signaling 9 binding protein
Aliases FLJ45744; R9AP; regulator of G protein signalling 9 binding protein; RGS9 anchor protein; RGS9-anchoring pro ......
Chromosomal Location19q13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of RGS9BP expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolRGS9BP
Nameregulator of G protein signaling 9 binding protein
Aliases FLJ45744; R9AP; regulator of G protein signalling 9 binding protein; RGS9 anchor protein; RGS9-anchoring pro ......
Chromosomal Location19q13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between RGS9BP and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolRGS9BP
Nameregulator of G protein signaling 9 binding protein
Aliases FLJ45744; R9AP; regulator of G protein signalling 9 binding protein; RGS9 anchor protein; RGS9-anchoring pro ......
Chromosomal Location19q13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting RGS9BP collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.