Summary | |
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Symbol | RHOU |
Name | ras homolog family member U |
Aliases | WRCH-1; DJ646B12.2; FLJ10616; WRCH1; CDC42L1; hG28K; fJ646B12.2; Ryu GTPase; Wnt-1 responsive Cdc42 homolog; ...... |
Chromosomal Location | 1q42.11-q42.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Lipid-anchor Cytoplasmic side Golgi apparatus membrane Lipid-anchor Cell junction, focal adhesion Cell projection, podosome Note=Localizes to podosomes in SRC-transformed cells. |
Domain |
PF00071 Ras family |
Function |
Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. |
Biological Process |
GO:0000082 G1/S transition of mitotic cell cycle GO:0006626 protein targeting to mitochondrion GO:0006839 mitochondrial transport GO:0007265 Ras protein signal transduction GO:0008360 regulation of cell shape GO:0010821 regulation of mitochondrion organization GO:0010822 positive regulation of mitochondrion organization GO:0016601 Rac protein signal transduction GO:0022604 regulation of cell morphogenesis GO:0032386 regulation of intracellular transport GO:0032388 positive regulation of intracellular transport GO:0033157 regulation of intracellular protein transport GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0044843 cell cycle G1/S phase transition GO:0051056 regulation of small GTPase mediated signal transduction GO:0051222 positive regulation of protein transport GO:0070585 protein localization to mitochondrion GO:0072655 establishment of protein localization to mitochondrion GO:0090316 positive regulation of intracellular protein transport GO:1903214 regulation of protein targeting to mitochondrion GO:1903533 regulation of protein targeting GO:1903747 regulation of establishment of protein localization to mitochondrion GO:1903749 positive regulation of establishment of protein localization to mitochondrion GO:1903829 positive regulation of cellular protein localization GO:1903955 positive regulation of protein targeting to mitochondrion GO:1904951 positive regulation of establishment of protein localization |
Molecular Function |
GO:0003924 GTPase activity GO:0005525 GTP binding GO:0019001 guanyl nucleotide binding GO:0032561 guanyl ribonucleotide binding |
Cellular Component |
GO:0002102 podosome GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0015629 actin cytoskeleton GO:0030055 cell-substrate junction |
KEGG | - |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-6785807: Interleukin-4 and 13 signaling R-HSA-194840: Rho GTPase cycle R-HSA-162582: Signal Transduction R-HSA-449147: Signaling by Interleukins R-HSA-194315: Signaling by Rho GTPases |
Summary | |
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Symbol | RHOU |
Name | ras homolog family member U |
Aliases | WRCH-1; DJ646B12.2; FLJ10616; WRCH1; CDC42L1; hG28K; fJ646B12.2; Ryu GTPase; Wnt-1 responsive Cdc42 homolog; ...... |
Chromosomal Location | 1q42.11-q42.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between RHOU and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | RHOU |
Name | ras homolog family member U |
Aliases | WRCH-1; DJ646B12.2; FLJ10616; WRCH1; CDC42L1; hG28K; fJ646B12.2; Ryu GTPase; Wnt-1 responsive Cdc42 homolog; ...... |
Chromosomal Location | 1q42.11-q42.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of RHOU in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | RHOU |
Name | ras homolog family member U |
Aliases | WRCH-1; DJ646B12.2; FLJ10616; WRCH1; CDC42L1; hG28K; fJ646B12.2; Ryu GTPase; Wnt-1 responsive Cdc42 homolog; ...... |
Chromosomal Location | 1q42.11-q42.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of RHOU in various data sets.
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Points in the above scatter plot represent the mutation difference of RHOU in various data sets.
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Summary | |
---|---|
Symbol | RHOU |
Name | ras homolog family member U |
Aliases | WRCH-1; DJ646B12.2; FLJ10616; WRCH1; CDC42L1; hG28K; fJ646B12.2; Ryu GTPase; Wnt-1 responsive Cdc42 homolog; ...... |
Chromosomal Location | 1q42.11-q42.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RHOU. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | RHOU |
Name | ras homolog family member U |
Aliases | WRCH-1; DJ646B12.2; FLJ10616; WRCH1; CDC42L1; hG28K; fJ646B12.2; Ryu GTPase; Wnt-1 responsive Cdc42 homolog; ...... |
Chromosomal Location | 1q42.11-q42.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RHOU. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RHOU. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | RHOU |
Name | ras homolog family member U |
Aliases | WRCH-1; DJ646B12.2; FLJ10616; WRCH1; CDC42L1; hG28K; fJ646B12.2; Ryu GTPase; Wnt-1 responsive Cdc42 homolog; ...... |
Chromosomal Location | 1q42.11-q42.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RHOU. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | RHOU |
Name | ras homolog family member U |
Aliases | WRCH-1; DJ646B12.2; FLJ10616; WRCH1; CDC42L1; hG28K; fJ646B12.2; Ryu GTPase; Wnt-1 responsive Cdc42 homolog; ...... |
Chromosomal Location | 1q42.11-q42.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of RHOU expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | RHOU |
Name | ras homolog family member U |
Aliases | WRCH-1; DJ646B12.2; FLJ10616; WRCH1; CDC42L1; hG28K; fJ646B12.2; Ryu GTPase; Wnt-1 responsive Cdc42 homolog; ...... |
Chromosomal Location | 1q42.11-q42.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between RHOU and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | RHOU |
Name | ras homolog family member U |
Aliases | WRCH-1; DJ646B12.2; FLJ10616; WRCH1; CDC42L1; hG28K; fJ646B12.2; Ryu GTPase; Wnt-1 responsive Cdc42 homolog; ...... |
Chromosomal Location | 1q42.11-q42.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting RHOU collected from DrugBank database. |
There is no record. |