Summary | |
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Symbol | RIPK2 |
Name | receptor-interacting serine-threonine kinase 2 |
Aliases | RICK; CARDIAK; CARD3; GIG30; CARD-carrying kinase; CARD-containing IL-1 beta ICE-kinase; CARD-containing int ...... |
Chromosomal Location | 8q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm |
Domain |
PF00619 Caspase recruitment domain PF07714 Protein tyrosine kinase |
Function |
Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation. |
Biological Process |
GO:0000187 activation of MAPK activity GO:0001819 positive regulation of cytokine production GO:0001959 regulation of cytokine-mediated signaling pathway GO:0001961 positive regulation of cytokine-mediated signaling pathway GO:0002218 activation of innate immune response GO:0002221 pattern recognition receptor signaling pathway GO:0002224 toll-like receptor signaling pathway GO:0002237 response to molecule of bacterial origin GO:0002250 adaptive immune response GO:0002263 cell activation involved in immune response GO:0002285 lymphocyte activation involved in immune response GO:0002286 T cell activation involved in immune response GO:0002287 alpha-beta T cell activation involved in immune response GO:0002292 T cell differentiation involved in immune response GO:0002293 alpha-beta T cell differentiation involved in immune response GO:0002294 CD4-positive, alpha-beta T cell differentiation involved in immune response GO:0002366 leukocyte activation involved in immune response GO:0002429 immune response-activating cell surface receptor signaling pathway GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002521 leukocyte differentiation GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002697 regulation of immune effector process GO:0002699 positive regulation of immune effector process GO:0002753 cytoplasmic pattern recognition receptor signaling pathway GO:0002757 immune response-activating signal transduction GO:0002758 innate immune response-activating signal transduction GO:0002764 immune response-regulating signaling pathway GO:0002768 immune response-regulating cell surface receptor signaling pathway GO:0002819 regulation of adaptive immune response GO:0002821 positive regulation of adaptive immune response GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002825 regulation of T-helper 1 type immune response GO:0002827 positive regulation of T-helper 1 type immune response GO:0002831 regulation of response to biotic stimulus GO:0002833 positive regulation of response to biotic stimulus GO:0006914 autophagy GO:0007159 leukocyte cell-cell adhesion GO:0007249 I-kappaB kinase/NF-kappaB signaling GO:0007254 JNK cascade GO:0010506 regulation of autophagy GO:0010508 positive regulation of autophagy GO:0010799 regulation of peptidyl-threonine phosphorylation GO:0010800 positive regulation of peptidyl-threonine phosphorylation GO:0016236 macroautophagy GO:0016239 positive regulation of macroautophagy GO:0016241 regulation of macroautophagy GO:0018105 peptidyl-serine phosphorylation GO:0018107 peptidyl-threonine phosphorylation GO:0018108 peptidyl-tyrosine phosphorylation GO:0018209 peptidyl-serine modification GO:0018210 peptidyl-threonine modification GO:0018212 peptidyl-tyrosine modification GO:0022407 regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0030098 lymphocyte differentiation GO:0030217 T cell differentiation GO:0030522 intracellular receptor signaling pathway GO:0031098 stress-activated protein kinase signaling cascade GO:0031349 positive regulation of defense response GO:0031396 regulation of protein ubiquitination GO:0031398 positive regulation of protein ubiquitination GO:0031663 lipopolysaccharide-mediated signaling pathway GO:0032103 positive regulation of response to external stimulus GO:0032147 activation of protein kinase activity GO:0032479 regulation of type I interferon production GO:0032481 positive regulation of type I interferon production GO:0032494 response to peptidoglycan GO:0032495 response to muramyl dipeptide GO:0032496 response to lipopolysaccharide GO:0032602 chemokine production GO:0032606 type I interferon production GO:0032607 interferon-alpha production GO:0032608 interferon-beta production GO:0032609 interferon-gamma production GO:0032615 interleukin-12 production GO:0032623 interleukin-2 production GO:0032635 interleukin-6 production GO:0032640 tumor necrosis factor production GO:0032642 regulation of chemokine production GO:0032647 regulation of interferon-alpha production GO:0032648 regulation of interferon-beta production GO:0032649 regulation of interferon-gamma production GO:0032655 regulation of interleukin-12 production GO:0032663 regulation of interleukin-2 production GO:0032675 regulation of interleukin-6 production GO:0032680 regulation of tumor necrosis factor production GO:0032722 positive regulation of chemokine production GO:0032727 positive regulation of interferon-alpha production GO:0032728 positive regulation of interferon-beta production GO:0032729 positive regulation of interferon-gamma production GO:0032735 positive regulation of interleukin-12 production GO:0032743 positive regulation of interleukin-2 production GO:0032755 positive regulation of interleukin-6 production GO:0032760 positive regulation of tumor necrosis factor production GO:0032872 regulation of stress-activated MAPK cascade GO:0032874 positive regulation of stress-activated MAPK cascade GO:0032943 mononuclear cell proliferation GO:0032944 regulation of mononuclear cell proliferation GO:0032946 positive regulation of mononuclear cell proliferation GO:0033079 immature T cell proliferation GO:0033083 regulation of immature T cell proliferation GO:0033091 positive regulation of immature T cell proliferation GO:0033135 regulation of peptidyl-serine phosphorylation GO:0033138 positive regulation of peptidyl-serine phosphorylation GO:0033674 positive regulation of kinase activity GO:0034134 toll-like receptor 2 signaling pathway GO:0034142 toll-like receptor 4 signaling pathway GO:0035710 CD4-positive, alpha-beta T cell activation GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway GO:0042088 T-helper 1 type immune response GO:0042093 T-helper cell differentiation GO:0042098 T cell proliferation GO:0042102 positive regulation of T cell proliferation GO:0042110 T cell activation GO:0042129 regulation of T cell proliferation GO:0042742 defense response to bacterium GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043330 response to exogenous dsRNA GO:0043331 response to dsRNA GO:0043367 CD4-positive, alpha-beta T cell differentiation GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation GO:0043405 regulation of MAP kinase activity GO:0043406 positive regulation of MAP kinase activity GO:0043410 positive regulation of MAPK cascade GO:0043900 regulation of multi-organism process GO:0043902 positive regulation of multi-organism process GO:0045063 T-helper 1 cell differentiation GO:0045088 regulation of innate immune response GO:0045089 positive regulation of innate immune response GO:0045580 regulation of T cell differentiation GO:0045582 positive regulation of T cell differentiation GO:0045619 regulation of lymphocyte differentiation GO:0045621 positive regulation of lymphocyte differentiation GO:0045622 regulation of T-helper cell differentiation GO:0045624 positive regulation of T-helper cell differentiation GO:0045625 regulation of T-helper 1 cell differentiation GO:0045627 positive regulation of T-helper 1 cell differentiation GO:0045785 positive regulation of cell adhesion GO:0045860 positive regulation of protein kinase activity GO:0046328 regulation of JNK cascade GO:0046330 positive regulation of JNK cascade GO:0046631 alpha-beta T cell activation GO:0046632 alpha-beta T cell differentiation GO:0046633 alpha-beta T cell proliferation GO:0046634 regulation of alpha-beta T cell activation GO:0046635 positive regulation of alpha-beta T cell activation GO:0046637 regulation of alpha-beta T cell differentiation GO:0046638 positive regulation of alpha-beta T cell differentiation GO:0046640 regulation of alpha-beta T cell proliferation GO:0046641 positive regulation of alpha-beta T cell proliferation GO:0046651 lymphocyte proliferation GO:0050670 regulation of lymphocyte proliferation GO:0050671 positive regulation of lymphocyte proliferation GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0050830 defense response to Gram-positive bacterium GO:0050851 antigen receptor-mediated signaling pathway GO:0050852 T cell receptor signaling pathway GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050870 positive regulation of T cell activation GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051092 positive regulation of NF-kappaB transcription factor activity GO:0051249 regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0051403 stress-activated MAPK cascade GO:0060759 regulation of response to cytokine stimulus GO:0060760 positive regulation of response to cytokine stimulus GO:0070302 regulation of stress-activated protein kinase signaling cascade GO:0070304 positive regulation of stress-activated protein kinase signaling cascade GO:0070371 ERK1 and ERK2 cascade GO:0070372 regulation of ERK1 and ERK2 cascade GO:0070374 positive regulation of ERK1 and ERK2 cascade GO:0070391 response to lipoteichoic acid GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070555 response to interleukin-1 GO:0070661 leukocyte proliferation GO:0070663 regulation of leukocyte proliferation GO:0070665 positive regulation of leukocyte proliferation GO:0070671 response to interleukin-12 GO:0070673 response to interleukin-18 GO:0071216 cellular response to biotic stimulus GO:0071219 cellular response to molecule of bacterial origin GO:0071222 cellular response to lipopolysaccharide GO:0071223 cellular response to lipoteichoic acid GO:0071224 cellular response to peptidoglycan GO:0071225 cellular response to muramyl dipeptide GO:0071396 cellular response to lipid GO:0071417 cellular response to organonitrogen compound GO:0071593 lymphocyte aggregation GO:0071706 tumor necrosis factor superfamily cytokine production GO:0071900 regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity GO:0098542 defense response to other organism GO:0098792 xenophagy GO:1901652 response to peptide GO:1901653 cellular response to peptide GO:1902105 regulation of leukocyte differentiation GO:1902107 positive regulation of leukocyte differentiation GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion GO:1903320 regulation of protein modification by small protein conjugation or removal GO:1903322 positive regulation of protein modification by small protein conjugation or removal GO:1903555 regulation of tumor necrosis factor superfamily cytokine production GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production GO:1903706 regulation of hemopoiesis GO:1903708 positive regulation of hemopoiesis GO:1904415 regulation of xenophagy GO:1904417 positive regulation of xenophagy GO:2000514 regulation of CD4-positive, alpha-beta T cell activation GO:2000516 positive regulation of CD4-positive, alpha-beta T cell activation |
Molecular Function |
GO:0004674 protein serine/threonine kinase activity GO:0004713 protein tyrosine kinase activity GO:0004715 non-membrane spanning protein tyrosine kinase activity GO:0030274 LIM domain binding GO:0050700 CARD domain binding |
Cellular Component | - |
KEGG |
hsa04621 NOD-like receptor signaling pathway hsa04722 Neurotrophin signaling pathway |
Reactome |
R-HSA-166054: Activated TLR4 signalling R-HSA-1280218: Adaptive Immune System R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-5688426: Deubiquitination R-HSA-202424: Downstream TCR signaling R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-446652: Interleukin-1 signaling R-HSA-450321: JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450294: MAP kinase activation in TLR cascade R-HSA-392499: Metabolism of proteins R-HSA-975871: MyD88 cascade initiated on plasma membrane R-HSA-975155: MyD88 dependent cascade initiated on endosome R-HSA-166166: MyD88-independent TLR3/TLR4 cascade R-HSA-166058: MyD88 R-HSA-168638: NOD1/2 Signaling Pathway R-HSA-168643: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-5689896: Ovarian tumor domain proteases R-HSA-597592: Post-translational protein modification R-HSA-162582: Signal Transduction R-HSA-449147: Signaling by Interleukins R-HSA-166520: Signalling by NGF R-HSA-445989: TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-HSA-202403: TCR signaling R-HSA-168180: TRAF6 Mediated Induction of proinflammatory cytokines R-HSA-975138: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-937061: TRIF-mediated TLR3/TLR4 signaling R-HSA-168142: Toll Like Receptor 10 (TLR10) Cascade R-HSA-181438: Toll Like Receptor 2 (TLR2) Cascade R-HSA-168164: Toll Like Receptor 3 (TLR3) Cascade R-HSA-166016: Toll Like Receptor 4 (TLR4) Cascade R-HSA-168176: Toll Like Receptor 5 (TLR5) Cascade R-HSA-168181: Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168138: Toll Like Receptor 9 (TLR9) Cascade R-HSA-168179: Toll Like Receptor TLR1 R-HSA-168188: Toll Like Receptor TLR6 R-HSA-168898: Toll-Like Receptors Cascades R-HSA-450302: activated TAK1 mediates p38 MAPK activation R-HSA-193704: p75 NTR receptor-mediated signalling R-HSA-209543: p75NTR recruits signalling complexes R-HSA-193639: p75NTR signals via NF-kB |
Summary | |
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Symbol | RIPK2 |
Name | receptor-interacting serine-threonine kinase 2 |
Aliases | RICK; CARDIAK; CARD3; GIG30; CARD-carrying kinase; CARD-containing IL-1 beta ICE-kinase; CARD-containing int ...... |
Chromosomal Location | 8q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between RIPK2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | RIPK2 |
Name | receptor-interacting serine-threonine kinase 2 |
Aliases | RICK; CARDIAK; CARD3; GIG30; CARD-carrying kinase; CARD-containing IL-1 beta ICE-kinase; CARD-containing int ...... |
Chromosomal Location | 8q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of RIPK2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | RIPK2 |
Name | receptor-interacting serine-threonine kinase 2 |
Aliases | RICK; CARDIAK; CARD3; GIG30; CARD-carrying kinase; CARD-containing IL-1 beta ICE-kinase; CARD-containing int ...... |
Chromosomal Location | 8q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of RIPK2 in various data sets.
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Points in the above scatter plot represent the mutation difference of RIPK2 in various data sets.
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Summary | |
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Symbol | RIPK2 |
Name | receptor-interacting serine-threonine kinase 2 |
Aliases | RICK; CARDIAK; CARD3; GIG30; CARD-carrying kinase; CARD-containing IL-1 beta ICE-kinase; CARD-containing int ...... |
Chromosomal Location | 8q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RIPK2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | RIPK2 |
Name | receptor-interacting serine-threonine kinase 2 |
Aliases | RICK; CARDIAK; CARD3; GIG30; CARD-carrying kinase; CARD-containing IL-1 beta ICE-kinase; CARD-containing int ...... |
Chromosomal Location | 8q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RIPK2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RIPK2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | RIPK2 |
Name | receptor-interacting serine-threonine kinase 2 |
Aliases | RICK; CARDIAK; CARD3; GIG30; CARD-carrying kinase; CARD-containing IL-1 beta ICE-kinase; CARD-containing int ...... |
Chromosomal Location | 8q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RIPK2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | RIPK2 |
Name | receptor-interacting serine-threonine kinase 2 |
Aliases | RICK; CARDIAK; CARD3; GIG30; CARD-carrying kinase; CARD-containing IL-1 beta ICE-kinase; CARD-containing int ...... |
Chromosomal Location | 8q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of RIPK2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | RIPK2 |
Name | receptor-interacting serine-threonine kinase 2 |
Aliases | RICK; CARDIAK; CARD3; GIG30; CARD-carrying kinase; CARD-containing IL-1 beta ICE-kinase; CARD-containing int ...... |
Chromosomal Location | 8q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between RIPK2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | RIPK2 |
Name | receptor-interacting serine-threonine kinase 2 |
Aliases | RICK; CARDIAK; CARD3; GIG30; CARD-carrying kinase; CARD-containing IL-1 beta ICE-kinase; CARD-containing int ...... |
Chromosomal Location | 8q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting RIPK2 collected from DrugBank database. |
There is no record. |