Summary | |
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Symbol | RIT1 |
Name | Ras-like without CAAX 1 |
Aliases | RIBB; MGC125864; MGC125865; Ric-like, expressed in many tissues; GTP-binding protein Roc1; RIT; Ric (Drosoph ...... |
Chromosomal Location | 1q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane. |
Domain |
PF00071 Ras family |
Function |
Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation. |
Biological Process |
GO:0007265 Ras protein signal transduction |
Molecular Function |
GO:0003924 GTPase activity GO:0005516 calmodulin binding GO:0005525 GTP binding GO:0019001 guanyl nucleotide binding GO:0032561 guanyl ribonucleotide binding |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-187037: NGF signalling via TRKA from the plasma membrane R-HSA-162582: Signal Transduction R-HSA-166520: Signalling by NGF R-HSA-187687: Signalling to ERKs R-HSA-187706: Signalling to p38 via RIT and RIN |
Summary | |
---|---|
Symbol | RIT1 |
Name | Ras-like without CAAX 1 |
Aliases | RIBB; MGC125864; MGC125865; Ric-like, expressed in many tissues; GTP-binding protein Roc1; RIT; Ric (Drosoph ...... |
Chromosomal Location | 1q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between RIT1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between RIT1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | RIT1 |
Name | Ras-like without CAAX 1 |
Aliases | RIBB; MGC125864; MGC125865; Ric-like, expressed in many tissues; GTP-binding protein Roc1; RIT; Ric (Drosoph ...... |
Chromosomal Location | 1q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of RIT1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | RIT1 |
Name | Ras-like without CAAX 1 |
Aliases | RIBB; MGC125864; MGC125865; Ric-like, expressed in many tissues; GTP-binding protein Roc1; RIT; Ric (Drosoph ...... |
Chromosomal Location | 1q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of RIT1 in various data sets.
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Points in the above scatter plot represent the mutation difference of RIT1 in various data sets.
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Summary | |
---|---|
Symbol | RIT1 |
Name | Ras-like without CAAX 1 |
Aliases | RIBB; MGC125864; MGC125865; Ric-like, expressed in many tissues; GTP-binding protein Roc1; RIT; Ric (Drosoph ...... |
Chromosomal Location | 1q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RIT1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | RIT1 |
Name | Ras-like without CAAX 1 |
Aliases | RIBB; MGC125864; MGC125865; Ric-like, expressed in many tissues; GTP-binding protein Roc1; RIT; Ric (Drosoph ...... |
Chromosomal Location | 1q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RIT1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RIT1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | RIT1 |
Name | Ras-like without CAAX 1 |
Aliases | RIBB; MGC125864; MGC125865; Ric-like, expressed in many tissues; GTP-binding protein Roc1; RIT; Ric (Drosoph ...... |
Chromosomal Location | 1q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RIT1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | RIT1 |
Name | Ras-like without CAAX 1 |
Aliases | RIBB; MGC125864; MGC125865; Ric-like, expressed in many tissues; GTP-binding protein Roc1; RIT; Ric (Drosoph ...... |
Chromosomal Location | 1q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of RIT1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | RIT1 |
Name | Ras-like without CAAX 1 |
Aliases | RIBB; MGC125864; MGC125865; Ric-like, expressed in many tissues; GTP-binding protein Roc1; RIT; Ric (Drosoph ...... |
Chromosomal Location | 1q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between RIT1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | RIT1 |
Name | Ras-like without CAAX 1 |
Aliases | RIBB; MGC125864; MGC125865; Ric-like, expressed in many tissues; GTP-binding protein Roc1; RIT; Ric (Drosoph ...... |
Chromosomal Location | 1q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting RIT1 collected from DrugBank database. |
There is no record. |