Summary | |
---|---|
Symbol | RMI1 |
Name | RecQ mediated genome instability 1 |
Aliases | FLJ12888; BLAP75; BLM-Associated Polypeptide, 75 kDa; C9orf76; chromosome 9 open reading frame 76; RMI1, Rec ...... |
Chromosomal Location | 9q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Note=Forms foci in response to DNA damage. |
Domain |
PF16099 Recq-mediated genome instability protein 1 PF08585 RecQ mediated genome instability protein |
Function |
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability. |
Biological Process |
GO:0000731 DNA synthesis involved in DNA repair GO:0000732 strand displacement GO:0002021 response to dietary excess GO:0002023 reduction of food intake in response to dietary excess GO:0006260 DNA replication GO:0006310 DNA recombination GO:0007631 feeding behavior GO:0009743 response to carbohydrate GO:0009746 response to hexose GO:0009749 response to glucose GO:0009991 response to extracellular stimulus GO:0031667 response to nutrient levels GO:0033500 carbohydrate homeostasis GO:0034284 response to monosaccharide GO:0035264 multicellular organism growth GO:0042593 glucose homeostasis GO:0042755 eating behavior GO:0071897 DNA biosynthetic process GO:0072331 signal transduction by p53 class mediator GO:1901796 regulation of signal transduction by p53 class mediator |
Molecular Function | - |
Cellular Component | - |
KEGG |
hsa03460 Fanconi anemia pathway |
Reactome |
R-HSA-1640170: Cell Cycle R-HSA-69620: Cell Cycle Checkpoints R-HSA-5693532: DNA Double-Strand Break Repair R-HSA-73894: DNA Repair R-HSA-69481: G2/M Checkpoints R-HSA-69473: G2/M DNA damage checkpoint R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-5693567: HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) R-HSA-5685942: HDR through Homologous Recombination (HRR) R-HSA-5685938: HDR through Single Strand Annealing (SSA) R-HSA-5693579: Homologous DNA Pairing and Strand Exchange R-HSA-5693538: Homology Directed Repair R-HSA-5693616: Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693607: Processing of DNA double-strand break ends R-HSA-5633007: Regulation of TP53 Activity R-HSA-6804756: Regulation of TP53 Activity through Phosphorylation R-HSA-5693537: Resolution of D-Loop Structures R-HSA-5693568: Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693554: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-3700989: Transcriptional Regulation by TP53 |
Summary | |
---|---|
Symbol | RMI1 |
Name | RecQ mediated genome instability 1 |
Aliases | FLJ12888; BLAP75; BLM-Associated Polypeptide, 75 kDa; C9orf76; chromosome 9 open reading frame 76; RMI1, Rec ...... |
Chromosomal Location | 9q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between RMI1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | RMI1 |
Name | RecQ mediated genome instability 1 |
Aliases | FLJ12888; BLAP75; BLM-Associated Polypeptide, 75 kDa; C9orf76; chromosome 9 open reading frame 76; RMI1, Rec ...... |
Chromosomal Location | 9q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of RMI1 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | RMI1 |
Name | RecQ mediated genome instability 1 |
Aliases | FLJ12888; BLAP75; BLM-Associated Polypeptide, 75 kDa; C9orf76; chromosome 9 open reading frame 76; RMI1, Rec ...... |
Chromosomal Location | 9q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of RMI1 in various data sets.
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Points in the above scatter plot represent the mutation difference of RMI1 in various data sets.
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Summary | |
---|---|
Symbol | RMI1 |
Name | RecQ mediated genome instability 1 |
Aliases | FLJ12888; BLAP75; BLM-Associated Polypeptide, 75 kDa; C9orf76; chromosome 9 open reading frame 76; RMI1, Rec ...... |
Chromosomal Location | 9q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RMI1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | RMI1 |
Name | RecQ mediated genome instability 1 |
Aliases | FLJ12888; BLAP75; BLM-Associated Polypeptide, 75 kDa; C9orf76; chromosome 9 open reading frame 76; RMI1, Rec ...... |
Chromosomal Location | 9q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RMI1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RMI1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | RMI1 |
Name | RecQ mediated genome instability 1 |
Aliases | FLJ12888; BLAP75; BLM-Associated Polypeptide, 75 kDa; C9orf76; chromosome 9 open reading frame 76; RMI1, Rec ...... |
Chromosomal Location | 9q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RMI1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | RMI1 |
Name | RecQ mediated genome instability 1 |
Aliases | FLJ12888; BLAP75; BLM-Associated Polypeptide, 75 kDa; C9orf76; chromosome 9 open reading frame 76; RMI1, Rec ...... |
Chromosomal Location | 9q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of RMI1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | RMI1 |
Name | RecQ mediated genome instability 1 |
Aliases | FLJ12888; BLAP75; BLM-Associated Polypeptide, 75 kDa; C9orf76; chromosome 9 open reading frame 76; RMI1, Rec ...... |
Chromosomal Location | 9q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between RMI1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | RMI1 |
Name | RecQ mediated genome instability 1 |
Aliases | FLJ12888; BLAP75; BLM-Associated Polypeptide, 75 kDa; C9orf76; chromosome 9 open reading frame 76; RMI1, Rec ...... |
Chromosomal Location | 9q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting RMI1 collected from DrugBank database. |
There is no record. |