Summary | |
---|---|
Symbol | RNF113B |
Name | ring finger protein 113B |
Aliases | RNF161; ZNF183L1; zinc finger protein 183-like 1; bA10G5.1 |
Chromosomal Location | 13q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF00642 Zinc finger C-x8-C-x5-C-x3-H type (and similar) |
Function |
- |
Biological Process |
GO:0000375 RNA splicing, via transesterification reactions GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile GO:0000398 mRNA splicing, via spliceosome GO:0006397 mRNA processing GO:0008380 RNA splicing GO:0016074 snoRNA metabolic process GO:0034247 snoRNA splicing GO:0034470 ncRNA processing GO:0043144 snoRNA processing GO:0045292 mRNA cis splicing, via spliceosome |
Molecular Function | - |
Cellular Component |
GO:0005681 spliceosomal complex GO:0005684 U2-type spliceosomal complex |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | RNF113B |
Name | ring finger protein 113B |
Aliases | RNF161; ZNF183L1; zinc finger protein 183-like 1; bA10G5.1 |
Chromosomal Location | 13q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between RNF113B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | RNF113B |
Name | ring finger protein 113B |
Aliases | RNF161; ZNF183L1; zinc finger protein 183-like 1; bA10G5.1 |
Chromosomal Location | 13q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of RNF113B in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | RNF113B |
Name | ring finger protein 113B |
Aliases | RNF161; ZNF183L1; zinc finger protein 183-like 1; bA10G5.1 |
Chromosomal Location | 13q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of RNF113B in various data sets.
|
Points in the above scatter plot represent the mutation difference of RNF113B in various data sets.
|
Summary | |
---|---|
Symbol | RNF113B |
Name | ring finger protein 113B |
Aliases | RNF161; ZNF183L1; zinc finger protein 183-like 1; bA10G5.1 |
Chromosomal Location | 13q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RNF113B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | RNF113B |
Name | ring finger protein 113B |
Aliases | RNF161; ZNF183L1; zinc finger protein 183-like 1; bA10G5.1 |
Chromosomal Location | 13q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RNF113B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RNF113B. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | RNF113B |
Name | ring finger protein 113B |
Aliases | RNF161; ZNF183L1; zinc finger protein 183-like 1; bA10G5.1 |
Chromosomal Location | 13q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RNF113B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | RNF113B |
Name | ring finger protein 113B |
Aliases | RNF161; ZNF183L1; zinc finger protein 183-like 1; bA10G5.1 |
Chromosomal Location | 13q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of RNF113B expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | RNF113B |
Name | ring finger protein 113B |
Aliases | RNF161; ZNF183L1; zinc finger protein 183-like 1; bA10G5.1 |
Chromosomal Location | 13q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between RNF113B and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |