Summary | |
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Symbol | RNF212 |
Name | ring finger protein 212 |
Aliases | FLJ38841; LOC285498; hypothetical protein LOC285498; ZHP3; Probable E3 SUMO-protein ligase RNF212 |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Chromosome Note=Associates to the synaptonemal complex. Localizes to a minority of double-strand breaks (DSBs) sites. Marks crossover sites during midpachynema (By similarity). |
Domain |
PF14634 zinc-RING finger domain |
Function |
SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with CCNB1IP1/HEI10 in the regulation of meiotic recombination (By similarity). |
Biological Process |
GO:0006310 DNA recombination GO:0006311 meiotic gene conversion GO:0007059 chromosome segregation GO:0007126 meiotic nuclear division GO:0007127 meiosis I GO:0007129 synapsis GO:0007131 reciprocal meiotic recombination GO:0016925 protein sumoylation GO:0018205 peptidyl-lysine modification GO:0035822 gene conversion GO:0035825 reciprocal DNA recombination GO:0045132 meiotic chromosome segregation GO:0045143 homologous chromosome segregation GO:0051026 chiasma assembly GO:0051321 meiotic cell cycle GO:0070192 chromosome organization involved in meiotic cell cycle GO:0098813 nuclear chromosome segregation GO:1903046 meiotic cell cycle process |
Molecular Function |
GO:0016874 ligase activity |
Cellular Component |
GO:0000793 condensed chromosome GO:0000794 condensed nuclear chromosome GO:0000795 synaptonemal complex GO:0044454 nuclear chromosome part |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | RNF212 |
Name | ring finger protein 212 |
Aliases | FLJ38841; LOC285498; hypothetical protein LOC285498; ZHP3; Probable E3 SUMO-protein ligase RNF212 |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between RNF212 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | RNF212 |
Name | ring finger protein 212 |
Aliases | FLJ38841; LOC285498; hypothetical protein LOC285498; ZHP3; Probable E3 SUMO-protein ligase RNF212 |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of RNF212 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | RNF212 |
Name | ring finger protein 212 |
Aliases | FLJ38841; LOC285498; hypothetical protein LOC285498; ZHP3; Probable E3 SUMO-protein ligase RNF212 |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of RNF212 in various data sets.
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Points in the above scatter plot represent the mutation difference of RNF212 in various data sets.
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Summary | |
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Symbol | RNF212 |
Name | ring finger protein 212 |
Aliases | FLJ38841; LOC285498; hypothetical protein LOC285498; ZHP3; Probable E3 SUMO-protein ligase RNF212 |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RNF212. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | RNF212 |
Name | ring finger protein 212 |
Aliases | FLJ38841; LOC285498; hypothetical protein LOC285498; ZHP3; Probable E3 SUMO-protein ligase RNF212 |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RNF212. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RNF212. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | RNF212 |
Name | ring finger protein 212 |
Aliases | FLJ38841; LOC285498; hypothetical protein LOC285498; ZHP3; Probable E3 SUMO-protein ligase RNF212 |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RNF212. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | RNF212 |
Name | ring finger protein 212 |
Aliases | FLJ38841; LOC285498; hypothetical protein LOC285498; ZHP3; Probable E3 SUMO-protein ligase RNF212 |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of RNF212 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | RNF212 |
Name | ring finger protein 212 |
Aliases | FLJ38841; LOC285498; hypothetical protein LOC285498; ZHP3; Probable E3 SUMO-protein ligase RNF212 |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between RNF212 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | RNF212 |
Name | ring finger protein 212 |
Aliases | FLJ38841; LOC285498; hypothetical protein LOC285498; ZHP3; Probable E3 SUMO-protein ligase RNF212 |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting RNF212 collected from DrugBank database. |
There is no record. |