Summary | |
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Symbol | ROBO1 |
Name | roundabout guidance receptor 1 |
Aliases | DUTT1; FLJ21882; roundabout (axon guidance receptor, Drosophila) homolog 1; roundabout, axon guidance recept ...... |
Chromosomal Location | 3p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass type I membrane protein Cell projection, axon Note=Detected at growth cones in thalamus neurons. |
Domain |
PF00041 Fibronectin type III domain PF07679 Immunoglobulin I-set domain |
Function |
Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development (PubMed:10102268, PubMed:24560577). Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). May be required for lung development (By similarity). |
Biological Process |
GO:0001525 angiogenesis GO:0001667 ameboidal-type cell migration GO:0001959 regulation of cytokine-mediated signaling pathway GO:0001960 negative regulation of cytokine-mediated signaling pathway GO:0002040 sprouting angiogenesis GO:0002042 cell migration involved in sprouting angiogenesis GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006929 substrate-dependent cell migration GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007265 Ras protein signal transduction GO:0007266 Rho protein signal transduction GO:0007409 axonogenesis GO:0007411 axon guidance GO:0007507 heart development GO:0008037 cell recognition GO:0008038 neuron recognition GO:0010631 epithelial cell migration GO:0010720 positive regulation of cell development GO:0010769 regulation of cell morphogenesis involved in differentiation GO:0010770 positive regulation of cell morphogenesis involved in differentiation GO:0010950 positive regulation of endopeptidase activity GO:0010952 positive regulation of peptidase activity GO:0010975 regulation of neuron projection development GO:0010976 positive regulation of neuron projection development GO:0016198 axon choice point recognition GO:0016199 axon midline choice point recognition GO:0021537 telencephalon development GO:0021543 pallium development GO:0021772 olfactory bulb development GO:0021795 cerebral cortex cell migration GO:0021800 cerebral cortex tangential migration GO:0021823 cerebral cortex tangential migration using cell-cell interactions GO:0021825 substrate-dependent cerebral cortex tangential migration GO:0021827 postnatal olfactory bulb interneuron migration GO:0021836 chemorepulsion involved in postnatal olfactory bulb interneuron migration GO:0021872 forebrain generation of neurons GO:0021879 forebrain neuron differentiation GO:0021884 forebrain neuron development GO:0021885 forebrain cell migration GO:0021889 olfactory bulb interneuron differentiation GO:0021891 olfactory bulb interneuron development GO:0021953 central nervous system neuron differentiation GO:0021954 central nervous system neuron development GO:0021987 cerebral cortex development GO:0021988 olfactory lobe development GO:0022028 tangential migration from the subventricular zone to the olfactory bulb GO:0022029 telencephalon cell migration GO:0022604 regulation of cell morphogenesis GO:0030336 negative regulation of cell migration GO:0030879 mammary gland development GO:0030900 forebrain development GO:0031346 positive regulation of cell projection organization GO:0032102 negative regulation of response to external stimulus GO:0033598 mammary gland epithelial cell proliferation GO:0033599 regulation of mammary gland epithelial cell proliferation GO:0033600 negative regulation of mammary gland epithelial cell proliferation GO:0035023 regulation of Rho protein signal transduction GO:0035025 positive regulation of Rho protein signal transduction GO:0035385 Roundabout signaling pathway GO:0040013 negative regulation of locomotion GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043534 blood vessel endothelial cell migration GO:0043542 endothelial cell migration GO:0045666 positive regulation of neuron differentiation GO:0045862 positive regulation of proteolysis GO:0046578 regulation of Ras protein signal transduction GO:0046579 positive regulation of Ras protein signal transduction GO:0048514 blood vessel morphogenesis GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048732 gland development GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0050680 negative regulation of epithelial cell proliferation GO:0050769 positive regulation of neurogenesis GO:0050770 regulation of axonogenesis GO:0050772 positive regulation of axonogenesis GO:0050919 negative chemotaxis GO:0050920 regulation of chemotaxis GO:0050922 negative regulation of chemotaxis GO:0050923 regulation of negative chemotaxis GO:0050925 negative regulation of negative chemotaxis GO:0051056 regulation of small GTPase mediated signal transduction GO:0051057 positive regulation of small GTPase mediated signal transduction GO:0051271 negative regulation of cellular component movement GO:0051962 positive regulation of nervous system development GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:0060759 regulation of response to cytokine stimulus GO:0060761 negative regulation of response to cytokine stimulus GO:0061180 mammary gland epithelium development GO:0061564 axon development GO:0070098 chemokine-mediated signaling pathway GO:0070099 regulation of chemokine-mediated signaling pathway GO:0070100 negative regulation of chemokine-mediated signaling pathway GO:0090130 tissue migration GO:0090132 epithelium migration GO:0097485 neuron projection guidance GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules GO:2000116 regulation of cysteine-type endopeptidase activity GO:2000146 negative regulation of cell motility GO:2001056 positive regulation of cysteine-type endopeptidase activity |
Molecular Function |
GO:0008046 axon guidance receptor activity GO:0030275 LRR domain binding |
Cellular Component |
GO:0030424 axon |
KEGG |
hsa04360 Axon guidance |
Reactome |
R-HSA-428540: Activation of Rac R-HSA-422475: Axon guidance R-HSA-1266738: Developmental Biology R-HSA-428543: Inactivation of Cdc42 and Rac R-HSA-373752: Netrin-1 signaling R-HSA-428542: Regulation of Commissural axon pathfinding by Slit and Robo R-HSA-428890: Role of Abl in Robo-Slit signaling R-HSA-376176: Signaling by Robo receptor |
Summary | |
---|---|
Symbol | ROBO1 |
Name | roundabout guidance receptor 1 |
Aliases | DUTT1; FLJ21882; roundabout (axon guidance receptor, Drosophila) homolog 1; roundabout, axon guidance recept ...... |
Chromosomal Location | 3p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ROBO1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ROBO1 |
Name | roundabout guidance receptor 1 |
Aliases | DUTT1; FLJ21882; roundabout (axon guidance receptor, Drosophila) homolog 1; roundabout, axon guidance recept ...... |
Chromosomal Location | 3p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ROBO1 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | ROBO1 |
Name | roundabout guidance receptor 1 |
Aliases | DUTT1; FLJ21882; roundabout (axon guidance receptor, Drosophila) homolog 1; roundabout, axon guidance recept ...... |
Chromosomal Location | 3p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ROBO1 in various data sets.
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Points in the above scatter plot represent the mutation difference of ROBO1 in various data sets.
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Summary | |
---|---|
Symbol | ROBO1 |
Name | roundabout guidance receptor 1 |
Aliases | DUTT1; FLJ21882; roundabout (axon guidance receptor, Drosophila) homolog 1; roundabout, axon guidance recept ...... |
Chromosomal Location | 3p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ROBO1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ROBO1 |
Name | roundabout guidance receptor 1 |
Aliases | DUTT1; FLJ21882; roundabout (axon guidance receptor, Drosophila) homolog 1; roundabout, axon guidance recept ...... |
Chromosomal Location | 3p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ROBO1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ROBO1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | ROBO1 |
Name | roundabout guidance receptor 1 |
Aliases | DUTT1; FLJ21882; roundabout (axon guidance receptor, Drosophila) homolog 1; roundabout, axon guidance recept ...... |
Chromosomal Location | 3p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ROBO1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ROBO1 |
Name | roundabout guidance receptor 1 |
Aliases | DUTT1; FLJ21882; roundabout (axon guidance receptor, Drosophila) homolog 1; roundabout, axon guidance recept ...... |
Chromosomal Location | 3p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ROBO1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ROBO1 |
Name | roundabout guidance receptor 1 |
Aliases | DUTT1; FLJ21882; roundabout (axon guidance receptor, Drosophila) homolog 1; roundabout, axon guidance recept ...... |
Chromosomal Location | 3p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ROBO1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ROBO1 |
Name | roundabout guidance receptor 1 |
Aliases | DUTT1; FLJ21882; roundabout (axon guidance receptor, Drosophila) homolog 1; roundabout, axon guidance recept ...... |
Chromosomal Location | 3p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ROBO1 collected from DrugBank database. |
There is no record. |