Browse ROM1

Summary
SymbolROM1
Nameretinal outer segment membrane protein 1
Aliases TSPAN23; ROM; ROSP1; tetraspanin-23; tspan-23; Rod outer segment membrane protein 1
Chromosomal Location11q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Membrane; Multi-pass membrane protein.
Domain PF00335 Tetraspanin family
Function

May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis.

> Gene Ontology
 
Biological Process GO:0001654 eye development
GO:0001754 eye photoreceptor cell differentiation
GO:0003407 neural retina development
GO:0007423 sensory organ development
GO:0007601 visual perception
GO:0043010 camera-type eye development
GO:0046530 photoreceptor cell differentiation
GO:0048592 eye morphogenesis
GO:0048593 camera-type eye morphogenesis
GO:0050953 sensory perception of light stimulus
GO:0060041 retina development in camera-type eye
GO:0060042 retina morphogenesis in camera-type eye
GO:0060219 camera-type eye photoreceptor cell differentiation
GO:0061298 retina vasculature development in camera-type eye
GO:0090596 sensory organ morphogenesis
Molecular Function -
Cellular Component GO:0001750 photoreceptor outer segment
GO:0005929 cilium
GO:0031253 cell projection membrane
GO:0031513 nonmotile primary cilium
GO:0042622 photoreceptor outer segment membrane
GO:0044441 ciliary part
GO:0060170 ciliary membrane
GO:0072372 primary cilium
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolROM1
Nameretinal outer segment membrane protein 1
Aliases TSPAN23; ROM; ROSP1; tetraspanin-23; tspan-23; Rod outer segment membrane protein 1
Chromosomal Location11q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ROM1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolROM1
Nameretinal outer segment membrane protein 1
Aliases TSPAN23; ROM; ROSP1; tetraspanin-23; tspan-23; Rod outer segment membrane protein 1
Chromosomal Location11q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ROM1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.71 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolROM1
Nameretinal outer segment membrane protein 1
Aliases TSPAN23; ROM; ROSP1; tetraspanin-23; tspan-23; Rod outer segment membrane protein 1
Chromosomal Location11q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ROM1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.3940.334
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.2750.137
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.2490.726
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0890.836
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.0730.947
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.2980.834
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.2960.28
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.2780.601
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.3240.569
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.4230.713
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.30.853
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0090.93
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ROM1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47014.3-14.31
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolROM1
Nameretinal outer segment membrane protein 1
Aliases TSPAN23; ROM; ROSP1; tetraspanin-23; tspan-23; Rod outer segment membrane protein 1
Chromosomal Location11q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ROM1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolROM1
Nameretinal outer segment membrane protein 1
Aliases TSPAN23; ROM; ROSP1; tetraspanin-23; tspan-23; Rod outer segment membrane protein 1
Chromosomal Location11q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ROM1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ROM1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolROM1
Nameretinal outer segment membrane protein 1
Aliases TSPAN23; ROM; ROSP1; tetraspanin-23; tspan-23; Rod outer segment membrane protein 1
Chromosomal Location11q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ROM1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolROM1
Nameretinal outer segment membrane protein 1
Aliases TSPAN23; ROM; ROSP1; tetraspanin-23; tspan-23; Rod outer segment membrane protein 1
Chromosomal Location11q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ROM1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolROM1
Nameretinal outer segment membrane protein 1
Aliases TSPAN23; ROM; ROSP1; tetraspanin-23; tspan-23; Rod outer segment membrane protein 1
Chromosomal Location11q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ROM1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolROM1
Nameretinal outer segment membrane protein 1
Aliases TSPAN23; ROM; ROSP1; tetraspanin-23; tspan-23; Rod outer segment membrane protein 1
Chromosomal Location11q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ROM1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.