Summary | |
---|---|
Symbol | ROM1 |
Name | retinal outer segment membrane protein 1 |
Aliases | TSPAN23; ROM; ROSP1; tetraspanin-23; tspan-23; Rod outer segment membrane protein 1 |
Chromosomal Location | 11q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane; Multi-pass membrane protein. |
Domain |
PF00335 Tetraspanin family |
Function |
May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis. |
Biological Process |
GO:0001654 eye development GO:0001754 eye photoreceptor cell differentiation GO:0003407 neural retina development GO:0007423 sensory organ development GO:0007601 visual perception GO:0043010 camera-type eye development GO:0046530 photoreceptor cell differentiation GO:0048592 eye morphogenesis GO:0048593 camera-type eye morphogenesis GO:0050953 sensory perception of light stimulus GO:0060041 retina development in camera-type eye GO:0060042 retina morphogenesis in camera-type eye GO:0060219 camera-type eye photoreceptor cell differentiation GO:0061298 retina vasculature development in camera-type eye GO:0090596 sensory organ morphogenesis |
Molecular Function | - |
Cellular Component |
GO:0001750 photoreceptor outer segment GO:0005929 cilium GO:0031253 cell projection membrane GO:0031513 nonmotile primary cilium GO:0042622 photoreceptor outer segment membrane GO:0044441 ciliary part GO:0060170 ciliary membrane GO:0072372 primary cilium |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | ROM1 |
Name | retinal outer segment membrane protein 1 |
Aliases | TSPAN23; ROM; ROSP1; tetraspanin-23; tspan-23; Rod outer segment membrane protein 1 |
Chromosomal Location | 11q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ROM1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ROM1 |
Name | retinal outer segment membrane protein 1 |
Aliases | TSPAN23; ROM; ROSP1; tetraspanin-23; tspan-23; Rod outer segment membrane protein 1 |
Chromosomal Location | 11q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of ROM1 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | ROM1 |
Name | retinal outer segment membrane protein 1 |
Aliases | TSPAN23; ROM; ROSP1; tetraspanin-23; tspan-23; Rod outer segment membrane protein 1 |
Chromosomal Location | 11q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ROM1 in various data sets.
|
Points in the above scatter plot represent the mutation difference of ROM1 in various data sets.
|
Summary | |
---|---|
Symbol | ROM1 |
Name | retinal outer segment membrane protein 1 |
Aliases | TSPAN23; ROM; ROSP1; tetraspanin-23; tspan-23; Rod outer segment membrane protein 1 |
Chromosomal Location | 11q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ROM1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ROM1 |
Name | retinal outer segment membrane protein 1 |
Aliases | TSPAN23; ROM; ROSP1; tetraspanin-23; tspan-23; Rod outer segment membrane protein 1 |
Chromosomal Location | 11q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ROM1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ROM1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | ROM1 |
Name | retinal outer segment membrane protein 1 |
Aliases | TSPAN23; ROM; ROSP1; tetraspanin-23; tspan-23; Rod outer segment membrane protein 1 |
Chromosomal Location | 11q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ROM1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ROM1 |
Name | retinal outer segment membrane protein 1 |
Aliases | TSPAN23; ROM; ROSP1; tetraspanin-23; tspan-23; Rod outer segment membrane protein 1 |
Chromosomal Location | 11q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ROM1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ROM1 |
Name | retinal outer segment membrane protein 1 |
Aliases | TSPAN23; ROM; ROSP1; tetraspanin-23; tspan-23; Rod outer segment membrane protein 1 |
Chromosomal Location | 11q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ROM1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ROM1 |
Name | retinal outer segment membrane protein 1 |
Aliases | TSPAN23; ROM; ROSP1; tetraspanin-23; tspan-23; Rod outer segment membrane protein 1 |
Chromosomal Location | 11q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ROM1 collected from DrugBank database. |
There is no record. |