Summary | |
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Symbol | ROPN1 |
Name | rhophilin associated tail protein 1 |
Aliases | ODF6; ropporin; ROPN1A; CT91; cancer/testis antigen 91; ropporin, rhophilin associated protein 1; RHPNAP1A; ...... |
Chromosomal Location | 3q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell projection, cilium, flagellum Note=In the sperm tail, found in the principal piece and in the cytoplasmic droplet located at the distal end of the midpiece. Inner surface of the fibrous sheath. |
Domain | - |
Function |
Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation. |
Biological Process | - |
Molecular Function | - |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-195258: RHO GTPase Effectors R-HSA-5666185: RHO GTPases Activate Rhotekin and Rhophilins R-HSA-162582: Signal Transduction R-HSA-194315: Signaling by Rho GTPases |
Summary | |
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Symbol | ROPN1 |
Name | rhophilin associated tail protein 1 |
Aliases | ODF6; ropporin; ROPN1A; CT91; cancer/testis antigen 91; ropporin, rhophilin associated protein 1; RHPNAP1A; ...... |
Chromosomal Location | 3q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ROPN1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ROPN1 |
Name | rhophilin associated tail protein 1 |
Aliases | ODF6; ropporin; ROPN1A; CT91; cancer/testis antigen 91; ropporin, rhophilin associated protein 1; RHPNAP1A; ...... |
Chromosomal Location | 3q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ROPN1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ROPN1 |
Name | rhophilin associated tail protein 1 |
Aliases | ODF6; ropporin; ROPN1A; CT91; cancer/testis antigen 91; ropporin, rhophilin associated protein 1; RHPNAP1A; ...... |
Chromosomal Location | 3q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ROPN1 in various data sets.
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Points in the above scatter plot represent the mutation difference of ROPN1 in various data sets.
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Summary | |
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Symbol | ROPN1 |
Name | rhophilin associated tail protein 1 |
Aliases | ODF6; ropporin; ROPN1A; CT91; cancer/testis antigen 91; ropporin, rhophilin associated protein 1; RHPNAP1A; ...... |
Chromosomal Location | 3q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ROPN1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ROPN1 |
Name | rhophilin associated tail protein 1 |
Aliases | ODF6; ropporin; ROPN1A; CT91; cancer/testis antigen 91; ropporin, rhophilin associated protein 1; RHPNAP1A; ...... |
Chromosomal Location | 3q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ROPN1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ROPN1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ROPN1 |
Name | rhophilin associated tail protein 1 |
Aliases | ODF6; ropporin; ROPN1A; CT91; cancer/testis antigen 91; ropporin, rhophilin associated protein 1; RHPNAP1A; ...... |
Chromosomal Location | 3q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ROPN1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ROPN1 |
Name | rhophilin associated tail protein 1 |
Aliases | ODF6; ropporin; ROPN1A; CT91; cancer/testis antigen 91; ropporin, rhophilin associated protein 1; RHPNAP1A; ...... |
Chromosomal Location | 3q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ROPN1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | ROPN1 |
Name | rhophilin associated tail protein 1 |
Aliases | ODF6; ropporin; ROPN1A; CT91; cancer/testis antigen 91; ropporin, rhophilin associated protein 1; RHPNAP1A; ...... |
Chromosomal Location | 3q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ROPN1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ROPN1 |
Name | rhophilin associated tail protein 1 |
Aliases | ODF6; ropporin; ROPN1A; CT91; cancer/testis antigen 91; ropporin, rhophilin associated protein 1; RHPNAP1A; ...... |
Chromosomal Location | 3q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ROPN1 collected from DrugBank database. |
There is no record. |