Summary | |
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Symbol | ROR1 |
Name | receptor tyrosine kinase-like orphan receptor 1 |
Aliases | NTRKR1; dJ537F10.1; neurotrophic tyrosine kinase, receptor-related 1; Inactive tyrosine-protein kinase trans ...... |
Chromosomal Location | 1p31.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Single-pass type I membrane protein. Cell projection, axon |
Domain |
PF01392 Fz domain PF07679 Immunoglobulin I-set domain PF00051 Kringle domain PF07714 Protein tyrosine kinase |
Function |
Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350). |
Biological Process |
GO:0001736 establishment of planar polarity GO:0001738 morphogenesis of a polarized epithelium GO:0007164 establishment of tissue polarity GO:0016055 Wnt signaling pathway GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0035567 non-canonical Wnt signaling pathway GO:0060071 Wnt signaling pathway, planar cell polarity pathway GO:0090175 regulation of establishment of planar polarity GO:0198738 cell-cell signaling by wnt GO:1905330 regulation of morphogenesis of an epithelium GO:2000027 regulation of organ morphogenesis |
Molecular Function |
GO:0004713 protein tyrosine kinase activity GO:0004714 transmembrane receptor protein tyrosine kinase activity GO:0015026 coreceptor activity GO:0017147 Wnt-protein binding GO:0019199 transmembrane receptor protein kinase activity GO:0071936 coreceptor activity involved in Wnt signaling pathway GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway |
Cellular Component |
GO:0043235 receptor complex |
KEGG | - |
Reactome |
R-HSA-3858494: Beta-catenin independent WNT signaling R-HSA-4086400: PCP/CE pathway R-HSA-162582: Signal Transduction R-HSA-195721: Signaling by Wnt R-HSA-5140745: WNT5A-dependent internalization of FZD2, FZD5 and ROR2 |
Summary | |
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Symbol | ROR1 |
Name | receptor tyrosine kinase-like orphan receptor 1 |
Aliases | NTRKR1; dJ537F10.1; neurotrophic tyrosine kinase, receptor-related 1; Inactive tyrosine-protein kinase trans ...... |
Chromosomal Location | 1p31.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ROR1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between ROR1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | ROR1 |
Name | receptor tyrosine kinase-like orphan receptor 1 |
Aliases | NTRKR1; dJ537F10.1; neurotrophic tyrosine kinase, receptor-related 1; Inactive tyrosine-protein kinase trans ...... |
Chromosomal Location | 1p31.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ROR1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ROR1 |
Name | receptor tyrosine kinase-like orphan receptor 1 |
Aliases | NTRKR1; dJ537F10.1; neurotrophic tyrosine kinase, receptor-related 1; Inactive tyrosine-protein kinase trans ...... |
Chromosomal Location | 1p31.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ROR1 in various data sets.
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Points in the above scatter plot represent the mutation difference of ROR1 in various data sets.
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Summary | |
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Symbol | ROR1 |
Name | receptor tyrosine kinase-like orphan receptor 1 |
Aliases | NTRKR1; dJ537F10.1; neurotrophic tyrosine kinase, receptor-related 1; Inactive tyrosine-protein kinase trans ...... |
Chromosomal Location | 1p31.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ROR1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ROR1 |
Name | receptor tyrosine kinase-like orphan receptor 1 |
Aliases | NTRKR1; dJ537F10.1; neurotrophic tyrosine kinase, receptor-related 1; Inactive tyrosine-protein kinase trans ...... |
Chromosomal Location | 1p31.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ROR1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ROR1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ROR1 |
Name | receptor tyrosine kinase-like orphan receptor 1 |
Aliases | NTRKR1; dJ537F10.1; neurotrophic tyrosine kinase, receptor-related 1; Inactive tyrosine-protein kinase trans ...... |
Chromosomal Location | 1p31.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ROR1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ROR1 |
Name | receptor tyrosine kinase-like orphan receptor 1 |
Aliases | NTRKR1; dJ537F10.1; neurotrophic tyrosine kinase, receptor-related 1; Inactive tyrosine-protein kinase trans ...... |
Chromosomal Location | 1p31.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ROR1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | ROR1 |
Name | receptor tyrosine kinase-like orphan receptor 1 |
Aliases | NTRKR1; dJ537F10.1; neurotrophic tyrosine kinase, receptor-related 1; Inactive tyrosine-protein kinase trans ...... |
Chromosomal Location | 1p31.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ROR1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ROR1 |
Name | receptor tyrosine kinase-like orphan receptor 1 |
Aliases | NTRKR1; dJ537F10.1; neurotrophic tyrosine kinase, receptor-related 1; Inactive tyrosine-protein kinase trans ...... |
Chromosomal Location | 1p31.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ROR1 collected from DrugBank database. |
There is no record. |