Summary | |
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Symbol | ROS1 |
Name | ROS proto-oncogene 1 , receptor tyrosine kinase |
Aliases | MCF3; ROS; c-ros-1; v-ros avian UR2 sarcoma virus oncogene homolog 1; v-ros UR2 sarcoma virus oncogene homol ...... |
Chromosomal Location | 6q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass type I membrane protein |
Domain |
PF00041 Fibronectin type III domain PF07714 Protein tyrosine kinase |
Function |
Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2. |
Biological Process |
GO:0002064 epithelial cell development GO:0002065 columnar/cuboidal epithelial cell differentiation GO:0002066 columnar/cuboidal epithelial cell development GO:0006817 phosphate ion transport GO:0006820 anion transport GO:0007283 spermatogenesis GO:0010966 regulation of phosphate transport GO:0015698 inorganic anion transport GO:0016049 cell growth GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0031929 TOR signaling GO:0032006 regulation of TOR signaling GO:0038083 peptidyl-tyrosine autophosphorylation GO:0044070 regulation of anion transport GO:0046777 protein autophosphorylation GO:0048232 male gamete generation GO:0070371 ERK1 and ERK2 cascade GO:0070372 regulation of ERK1 and ERK2 cascade |
Molecular Function |
GO:0004713 protein tyrosine kinase activity GO:0004714 transmembrane receptor protein tyrosine kinase activity GO:0019199 transmembrane receptor protein kinase activity GO:0019902 phosphatase binding GO:0019903 protein phosphatase binding |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | ROS1 |
Name | ROS proto-oncogene 1 , receptor tyrosine kinase |
Aliases | MCF3; ROS; c-ros-1; v-ros avian UR2 sarcoma virus oncogene homolog 1; v-ros UR2 sarcoma virus oncogene homol ...... |
Chromosomal Location | 6q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ROS1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between ROS1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | ROS1 |
Name | ROS proto-oncogene 1 , receptor tyrosine kinase |
Aliases | MCF3; ROS; c-ros-1; v-ros avian UR2 sarcoma virus oncogene homolog 1; v-ros UR2 sarcoma virus oncogene homol ...... |
Chromosomal Location | 6q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ROS1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ROS1 |
Name | ROS proto-oncogene 1 , receptor tyrosine kinase |
Aliases | MCF3; ROS; c-ros-1; v-ros avian UR2 sarcoma virus oncogene homolog 1; v-ros UR2 sarcoma virus oncogene homol ...... |
Chromosomal Location | 6q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ROS1 in various data sets.
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Points in the above scatter plot represent the mutation difference of ROS1 in various data sets.
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Summary | |
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Symbol | ROS1 |
Name | ROS proto-oncogene 1 , receptor tyrosine kinase |
Aliases | MCF3; ROS; c-ros-1; v-ros avian UR2 sarcoma virus oncogene homolog 1; v-ros UR2 sarcoma virus oncogene homol ...... |
Chromosomal Location | 6q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ROS1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ROS1 |
Name | ROS proto-oncogene 1 , receptor tyrosine kinase |
Aliases | MCF3; ROS; c-ros-1; v-ros avian UR2 sarcoma virus oncogene homolog 1; v-ros UR2 sarcoma virus oncogene homol ...... |
Chromosomal Location | 6q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ROS1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ROS1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ROS1 |
Name | ROS proto-oncogene 1 , receptor tyrosine kinase |
Aliases | MCF3; ROS; c-ros-1; v-ros avian UR2 sarcoma virus oncogene homolog 1; v-ros UR2 sarcoma virus oncogene homol ...... |
Chromosomal Location | 6q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ROS1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ROS1 |
Name | ROS proto-oncogene 1 , receptor tyrosine kinase |
Aliases | MCF3; ROS; c-ros-1; v-ros avian UR2 sarcoma virus oncogene homolog 1; v-ros UR2 sarcoma virus oncogene homol ...... |
Chromosomal Location | 6q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ROS1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | ROS1 |
Name | ROS proto-oncogene 1 , receptor tyrosine kinase |
Aliases | MCF3; ROS; c-ros-1; v-ros avian UR2 sarcoma virus oncogene homolog 1; v-ros UR2 sarcoma virus oncogene homol ...... |
Chromosomal Location | 6q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ROS1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ROS1 |
Name | ROS proto-oncogene 1 , receptor tyrosine kinase |
Aliases | MCF3; ROS; c-ros-1; v-ros avian UR2 sarcoma virus oncogene homolog 1; v-ros UR2 sarcoma virus oncogene homol ...... |
Chromosomal Location | 6q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ROS1 collected from DrugBank database. |
There is no record. |