Summary | |
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Symbol | RPAP2 |
Name | RNA polymerase II associated protein 2 |
Aliases | FLJ13150; Rtr1; C1orf82; chromosome 1 open reading frame 82; RNA polymerase II-associated protein 2; Putativ ...... |
Chromosomal Location | 1p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Nucleus Note=Shuttles between the cytoplasm and the nucleus in a CRM1-dependent manner. |
Domain |
PF04181 Rtr1/RPAP2 family |
Function |
Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes. |
Biological Process |
GO:0006470 protein dephosphorylation GO:0009301 snRNA transcription GO:0016073 snRNA metabolic process GO:0016311 dephosphorylation GO:0042795 snRNA transcription from RNA polymerase II promoter GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain GO:0098781 ncRNA transcription |
Molecular Function |
GO:0004721 phosphoprotein phosphatase activity GO:0004722 protein serine/threonine phosphatase activity GO:0008420 CTD phosphatase activity GO:0016791 phosphatase activity GO:0042578 phosphoric ester hydrolase activity |
Cellular Component |
GO:0000428 DNA-directed RNA polymerase complex GO:0016591 DNA-directed RNA polymerase II, holoenzyme GO:0030880 RNA polymerase complex GO:0055029 nuclear DNA-directed RNA polymerase complex GO:0061695 transferase complex, transferring phosphorus-containing groups |
KEGG | - |
Reactome |
R-HSA-74160: Gene Expression R-HSA-6807505: RNA polymerase II transcribes snRNA genes |
Summary | |
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Symbol | RPAP2 |
Name | RNA polymerase II associated protein 2 |
Aliases | FLJ13150; Rtr1; C1orf82; chromosome 1 open reading frame 82; RNA polymerase II-associated protein 2; Putativ ...... |
Chromosomal Location | 1p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between RPAP2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | RPAP2 |
Name | RNA polymerase II associated protein 2 |
Aliases | FLJ13150; Rtr1; C1orf82; chromosome 1 open reading frame 82; RNA polymerase II-associated protein 2; Putativ ...... |
Chromosomal Location | 1p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of RPAP2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | RPAP2 |
Name | RNA polymerase II associated protein 2 |
Aliases | FLJ13150; Rtr1; C1orf82; chromosome 1 open reading frame 82; RNA polymerase II-associated protein 2; Putativ ...... |
Chromosomal Location | 1p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of RPAP2 in various data sets.
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Points in the above scatter plot represent the mutation difference of RPAP2 in various data sets.
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Summary | |
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Symbol | RPAP2 |
Name | RNA polymerase II associated protein 2 |
Aliases | FLJ13150; Rtr1; C1orf82; chromosome 1 open reading frame 82; RNA polymerase II-associated protein 2; Putativ ...... |
Chromosomal Location | 1p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RPAP2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | RPAP2 |
Name | RNA polymerase II associated protein 2 |
Aliases | FLJ13150; Rtr1; C1orf82; chromosome 1 open reading frame 82; RNA polymerase II-associated protein 2; Putativ ...... |
Chromosomal Location | 1p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RPAP2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RPAP2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | RPAP2 |
Name | RNA polymerase II associated protein 2 |
Aliases | FLJ13150; Rtr1; C1orf82; chromosome 1 open reading frame 82; RNA polymerase II-associated protein 2; Putativ ...... |
Chromosomal Location | 1p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RPAP2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | RPAP2 |
Name | RNA polymerase II associated protein 2 |
Aliases | FLJ13150; Rtr1; C1orf82; chromosome 1 open reading frame 82; RNA polymerase II-associated protein 2; Putativ ...... |
Chromosomal Location | 1p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of RPAP2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | RPAP2 |
Name | RNA polymerase II associated protein 2 |
Aliases | FLJ13150; Rtr1; C1orf82; chromosome 1 open reading frame 82; RNA polymerase II-associated protein 2; Putativ ...... |
Chromosomal Location | 1p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between RPAP2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | RPAP2 |
Name | RNA polymerase II associated protein 2 |
Aliases | FLJ13150; Rtr1; C1orf82; chromosome 1 open reading frame 82; RNA polymerase II-associated protein 2; Putativ ...... |
Chromosomal Location | 1p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting RPAP2 collected from DrugBank database. |
There is no record. |