Summary | |
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Symbol | RPL38 |
Name | ribosomal protein L38 |
Aliases | L38; 60S ribosomal protein L38 |
Chromosomal Location | 17q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF01781 Ribosomal L38e protein family |
Function |
- |
Biological Process |
GO:0000027 ribosomal large subunit assembly GO:0000028 ribosomal small subunit assembly GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000956 nuclear-transcribed mRNA catabolic process GO:0001501 skeletal system development GO:0001503 ossification GO:0006364 rRNA processing GO:0006401 RNA catabolic process GO:0006402 mRNA catabolic process GO:0006413 translational initiation GO:0006417 regulation of translation GO:0006612 protein targeting to membrane GO:0006613 cotranslational protein targeting to membrane GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0007423 sensory organ development GO:0007498 mesoderm development GO:0007605 sensory perception of sound GO:0010608 posttranscriptional regulation of gene expression GO:0016072 rRNA metabolic process GO:0019058 viral life cycle GO:0019080 viral gene expression GO:0019083 viral transcription GO:0019439 aromatic compound catabolic process GO:0022613 ribonucleoprotein complex biogenesis GO:0022618 ribonucleoprotein complex assembly GO:0034248 regulation of cellular amide metabolic process GO:0034463 90S preribosome assembly GO:0034470 ncRNA processing GO:0034655 nucleobase-containing compound catabolic process GO:0042254 ribosome biogenesis GO:0042255 ribosome assembly GO:0042273 ribosomal large subunit biogenesis GO:0042274 ribosomal small subunit biogenesis GO:0042471 ear morphogenesis GO:0042474 middle ear morphogenesis GO:0043583 ear development GO:0044033 multi-organism metabolic process GO:0044270 cellular nitrogen compound catabolic process GO:0045047 protein targeting to ER GO:0046700 heterocycle catabolic process GO:0048318 axial mesoderm development GO:0048562 embryonic organ morphogenesis GO:0048568 embryonic organ development GO:0050954 sensory perception of mechanical stimulus GO:0070972 protein localization to endoplasmic reticulum GO:0071826 ribonucleoprotein complex subunit organization GO:0072599 establishment of protein localization to endoplasmic reticulum GO:0072657 protein localization to membrane GO:0090150 establishment of protein localization to membrane GO:0090596 sensory organ morphogenesis GO:1901361 organic cyclic compound catabolic process |
Molecular Function |
GO:0003735 structural constituent of ribosome |
Cellular Component |
GO:0005840 ribosome GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0015934 large ribosomal subunit GO:0022625 cytosolic large ribosomal subunit GO:0022626 cytosolic ribosome GO:0030055 cell-substrate junction GO:0033291 eukaryotic 80S initiation complex GO:0044391 ribosomal subunit GO:0044445 cytosolic part GO:0070992 translation initiation complex |
KEGG |
hsa03010 Ribosome |
Reactome |
R-HSA-157279: 3' -UTR-mediated translational regulation R-HSA-72737: Cap-dependent Translation Initiation R-HSA-1643685: Disease R-HSA-156842: Eukaryotic Translation Elongation R-HSA-72613: Eukaryotic Translation Initiation R-HSA-72764: Eukaryotic Translation Termination R-HSA-72689: Formation of a pool of free 40S subunits R-HSA-72706: GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-74160: Gene Expression R-HSA-5663205: Infectious disease R-HSA-168254: Influenza Infection R-HSA-168255: Influenza Life Cycle R-HSA-168273: Influenza Viral RNA Transcription and Replication R-HSA-156827: L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-6791226: Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-1430728: Metabolism R-HSA-71291: Metabolism of amino acids and derivatives R-HSA-392499: Metabolism of proteins R-HSA-975957: Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975956: Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-927802: Nonsense-Mediated Decay (NMD) R-HSA-156902: Peptide chain elongation R-HSA-1799339: SRP-dependent cotranslational protein targeting to membrane R-HSA-2408522: Selenoamino acid metabolism R-HSA-2408557: Selenocysteine synthesis R-HSA-72766: Translation R-HSA-192823: Viral mRNA Translation R-HSA-72312: rRNA processing R-HSA-8868773: rRNA processing in the nucleus and cytosol |
Summary | |
---|---|
Symbol | RPL38 |
Name | ribosomal protein L38 |
Aliases | L38; 60S ribosomal protein L38 |
Chromosomal Location | 17q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between RPL38 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | RPL38 |
Name | ribosomal protein L38 |
Aliases | L38; 60S ribosomal protein L38 |
Chromosomal Location | 17q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of RPL38 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | RPL38 |
Name | ribosomal protein L38 |
Aliases | L38; 60S ribosomal protein L38 |
Chromosomal Location | 17q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of RPL38 in various data sets.
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There is no record. |
Summary | |
---|---|
Symbol | RPL38 |
Name | ribosomal protein L38 |
Aliases | L38; 60S ribosomal protein L38 |
Chromosomal Location | 17q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RPL38. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | RPL38 |
Name | ribosomal protein L38 |
Aliases | L38; 60S ribosomal protein L38 |
Chromosomal Location | 17q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RPL38. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RPL38. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | RPL38 |
Name | ribosomal protein L38 |
Aliases | L38; 60S ribosomal protein L38 |
Chromosomal Location | 17q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RPL38. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | RPL38 |
Name | ribosomal protein L38 |
Aliases | L38; 60S ribosomal protein L38 |
Chromosomal Location | 17q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of RPL38 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | RPL38 |
Name | ribosomal protein L38 |
Aliases | L38; 60S ribosomal protein L38 |
Chromosomal Location | 17q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between RPL38 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |