Summary | |
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Symbol | RPN1 |
Name | ribophorin I |
Aliases | OST1; oligosaccharyltransferase 1 homolog (S. cerevisiae); RBPH1; RPN-I; dolichyl-diphosphooligosaccharide-- ...... |
Chromosomal Location | 3q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Endoplasmic reticulum Endoplasmic reticulum membrane; Single-pass type I membrane protein Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
Domain |
PF04597 Ribophorin I |
Function |
Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. |
Biological Process |
GO:0006486 protein glycosylation GO:0006487 protein N-linked glycosylation GO:0009100 glycoprotein metabolic process GO:0009101 glycoprotein biosynthetic process GO:0018196 peptidyl-asparagine modification GO:0018279 protein N-linked glycosylation via asparagine GO:0043413 macromolecule glycosylation GO:0070085 glycosylation |
Molecular Function |
GO:0004576 oligosaccharyl transferase activity GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity GO:0016757 transferase activity, transferring glycosyl groups GO:0016758 transferase activity, transferring hexosyl groups |
Cellular Component |
GO:0005791 rough endoplasmic reticulum GO:0008250 oligosaccharyltransferase complex GO:0042470 melanosome GO:0048770 pigment granule |
KEGG |
hsa04141 Protein processing in endoplasmic reticulum hsa00510 N-Glycan biosynthesis hsa01100 Metabolic pathways |
Reactome |
R-HSA-446203: Asparagine N-linked glycosylation R-HSA-74160: Gene Expression R-HSA-392499: Metabolism of proteins R-HSA-597592: Post-translational protein modification R-HSA-1799339: SRP-dependent cotranslational protein targeting to membrane R-HSA-72766: Translation |
Summary | |
---|---|
Symbol | RPN1 |
Name | ribophorin I |
Aliases | OST1; oligosaccharyltransferase 1 homolog (S. cerevisiae); RBPH1; RPN-I; dolichyl-diphosphooligosaccharide-- ...... |
Chromosomal Location | 3q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between RPN1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | RPN1 |
Name | ribophorin I |
Aliases | OST1; oligosaccharyltransferase 1 homolog (S. cerevisiae); RBPH1; RPN-I; dolichyl-diphosphooligosaccharide-- ...... |
Chromosomal Location | 3q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of RPN1 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | RPN1 |
Name | ribophorin I |
Aliases | OST1; oligosaccharyltransferase 1 homolog (S. cerevisiae); RBPH1; RPN-I; dolichyl-diphosphooligosaccharide-- ...... |
Chromosomal Location | 3q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of RPN1 in various data sets.
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Points in the above scatter plot represent the mutation difference of RPN1 in various data sets.
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Summary | |
---|---|
Symbol | RPN1 |
Name | ribophorin I |
Aliases | OST1; oligosaccharyltransferase 1 homolog (S. cerevisiae); RBPH1; RPN-I; dolichyl-diphosphooligosaccharide-- ...... |
Chromosomal Location | 3q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RPN1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | RPN1 |
Name | ribophorin I |
Aliases | OST1; oligosaccharyltransferase 1 homolog (S. cerevisiae); RBPH1; RPN-I; dolichyl-diphosphooligosaccharide-- ...... |
Chromosomal Location | 3q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RPN1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RPN1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | RPN1 |
Name | ribophorin I |
Aliases | OST1; oligosaccharyltransferase 1 homolog (S. cerevisiae); RBPH1; RPN-I; dolichyl-diphosphooligosaccharide-- ...... |
Chromosomal Location | 3q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RPN1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | RPN1 |
Name | ribophorin I |
Aliases | OST1; oligosaccharyltransferase 1 homolog (S. cerevisiae); RBPH1; RPN-I; dolichyl-diphosphooligosaccharide-- ...... |
Chromosomal Location | 3q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of RPN1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | RPN1 |
Name | ribophorin I |
Aliases | OST1; oligosaccharyltransferase 1 homolog (S. cerevisiae); RBPH1; RPN-I; dolichyl-diphosphooligosaccharide-- ...... |
Chromosomal Location | 3q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between RPN1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | RPN1 |
Name | ribophorin I |
Aliases | OST1; oligosaccharyltransferase 1 homolog (S. cerevisiae); RBPH1; RPN-I; dolichyl-diphosphooligosaccharide-- ...... |
Chromosomal Location | 3q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting RPN1 collected from DrugBank database. |
There is no record. |