Browse RPTOR

Summary
SymbolRPTOR
Nameregulatory associated protein of MTOR, complex 1
Aliases KOG1; KIAA1303; raptor; regulatory associated protein of mTOR; p150 target of rapamycin (TOR)-scaffold prote ......
Chromosomal Location17q25.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm. Lysosome. Cytoplasmic granule Note=Targeting to lysosomes depends on amino acid availability. In arsenite-stressed cells, accumulates in stress granules when associated with SPAG5 and association with lysosomes is drastically decreased.
Domain PF02985 HEAT repeat
PF14538 Raptor N-terminal CASPase like domain
PF00400 WD domain
Function

Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Involved in ciliogenesis.

> Gene Ontology
 
Biological Process GO:0001101 response to acid chemical
GO:0001935 endothelial cell proliferation
GO:0001936 regulation of endothelial cell proliferation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0006359 regulation of transcription from RNA polymerase III promoter
GO:0006383 transcription from RNA polymerase III promoter
GO:0006914 autophagy
GO:0007050 cell cycle arrest
GO:0008361 regulation of cell size
GO:0009266 response to temperature stimulus
GO:0009408 response to heat
GO:0009991 response to extracellular stimulus
GO:0016049 cell growth
GO:0016236 macroautophagy
GO:0031667 response to nutrient levels
GO:0031668 cellular response to extracellular stimulus
GO:0031669 cellular response to nutrient levels
GO:0031929 TOR signaling
GO:0032006 regulation of TOR signaling
GO:0032008 positive regulation of TOR signaling
GO:0032147 activation of protein kinase activity
GO:0032535 regulation of cellular component size
GO:0033674 positive regulation of kinase activity
GO:0034605 cellular response to heat
GO:0043200 response to amino acid
GO:0045786 negative regulation of cell cycle
GO:0045860 positive regulation of protein kinase activity
GO:0045945 positive regulation of transcription from RNA polymerase III promoter
GO:0050673 epithelial cell proliferation
GO:0050678 regulation of epithelial cell proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0071229 cellular response to acid chemical
GO:0071230 cellular response to amino acid stimulus
GO:0071417 cellular response to organonitrogen compound
GO:0071496 cellular response to external stimulus
GO:0071900 regulation of protein serine/threonine kinase activity
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0090066 regulation of anatomical structure size
GO:1900034 regulation of cellular response to heat
Molecular Function GO:0000182 rDNA binding
GO:0001016 RNA polymerase III regulatory region DNA binding
GO:0001025 RNA polymerase III transcription factor binding
GO:0001030 RNA polymerase III type 1 promoter DNA binding
GO:0001031 RNA polymerase III type 2 promoter DNA binding
GO:0001032 RNA polymerase III type 3 promoter DNA binding
GO:0001156 TFIIIC-class transcription factor binding
GO:0008047 enzyme activator activity
GO:0008134 transcription factor binding
GO:0019207 kinase regulator activity
GO:0019209 kinase activator activity
GO:0019887 protein kinase regulator activity
GO:0030295 protein kinase activator activity
GO:0030674 protein binding, bridging
GO:0060090 binding, bridging
GO:0071889 14-3-3 protein binding
GO:0080084 5S rDNA binding
Cellular Component GO:0005765 lysosomal membrane
GO:0030425 dendrite
GO:0031931 TORC1 complex
GO:0038201 TOR complex
GO:0043025 neuronal cell body
GO:0044297 cell body
GO:0098852 lytic vacuole membrane
> KEGG and Reactome Pathway
 
KEGG hsa04140 Regulation of autophagy
hsa04150 mTOR signaling pathway
hsa04151 PI3K-Akt signaling pathway
hsa04152 AMPK signaling pathway
hsa04910 Insulin signaling pathway
Reactome R-HSA-3371556: Cellular response to heat stress
R-HSA-2262752: Cellular responses to stress
R-HSA-380972: Energy dependent regulation of mTOR by LKB1-AMPK
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-3371571: HSF1-dependent transactivation
R-HSA-2428924: IGF1R signaling cascade
R-HSA-112399: IRS-mediated signalling
R-HSA-2428928: IRS-related events triggered by IGF1R
R-HSA-74751: Insulin receptor signalling cascade
R-HSA-1632852: Macroautophagy
R-HSA-109704: PI3K Cascade
R-HSA-109703: PKB-mediated events
R-HSA-162582: Signal Transduction
R-HSA-74752: Signaling by Insulin receptor
R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-HSA-5628897: TP53 Regulates Metabolic Genes
R-HSA-3700989: Transcriptional Regulation by TP53
R-HSA-165159: mTOR signalling
R-HSA-166208: mTORC1-mediated signalling
Summary
SymbolRPTOR
Nameregulatory associated protein of MTOR, complex 1
Aliases KOG1; KIAA1303; raptor; regulatory associated protein of mTOR; p150 target of rapamycin (TOR)-scaffold prote ......
Chromosomal Location17q25.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between RPTOR and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolRPTOR
Nameregulatory associated protein of MTOR, complex 1
Aliases KOG1; KIAA1303; raptor; regulatory associated protein of mTOR; p150 target of rapamycin (TOR)-scaffold prote ......
Chromosomal Location17q25.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of RPTOR in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.71 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolRPTOR
Nameregulatory associated protein of MTOR, complex 1
Aliases KOG1; KIAA1303; raptor; regulatory associated protein of mTOR; p150 target of rapamycin (TOR)-scaffold prote ......
Chromosomal Location17q25.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of RPTOR in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.3660.181
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.4590.767
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.3020.783
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.1690.526
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.1740.94
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.1650.956
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.290.386
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.1620.906
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.3940.803
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.3250.738
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.3650.799
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0340.492
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of RPTOR in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.15.91.21
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 414257.117.90.405
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.42.74.70.294
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.43.440.587
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.85.9-1.11
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.79.1-1.41
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91622.212.59.70.602
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59022.2-22.20.505
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47500500.109
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolRPTOR
Nameregulatory associated protein of MTOR, complex 1
Aliases KOG1; KIAA1303; raptor; regulatory associated protein of mTOR; p150 target of rapamycin (TOR)-scaffold prote ......
Chromosomal Location17q25.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RPTOR. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolRPTOR
Nameregulatory associated protein of MTOR, complex 1
Aliases KOG1; KIAA1303; raptor; regulatory associated protein of mTOR; p150 target of rapamycin (TOR)-scaffold prote ......
Chromosomal Location17q25.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RPTOR. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RPTOR.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolRPTOR
Nameregulatory associated protein of MTOR, complex 1
Aliases KOG1; KIAA1303; raptor; regulatory associated protein of mTOR; p150 target of rapamycin (TOR)-scaffold prote ......
Chromosomal Location17q25.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RPTOR. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolRPTOR
Nameregulatory associated protein of MTOR, complex 1
Aliases KOG1; KIAA1303; raptor; regulatory associated protein of mTOR; p150 target of rapamycin (TOR)-scaffold prote ......
Chromosomal Location17q25.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of RPTOR expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolRPTOR
Nameregulatory associated protein of MTOR, complex 1
Aliases KOG1; KIAA1303; raptor; regulatory associated protein of mTOR; p150 target of rapamycin (TOR)-scaffold prote ......
Chromosomal Location17q25.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between RPTOR and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolRPTOR
Nameregulatory associated protein of MTOR, complex 1
Aliases KOG1; KIAA1303; raptor; regulatory associated protein of mTOR; p150 target of rapamycin (TOR)-scaffold prote ......
Chromosomal Location17q25.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting RPTOR collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.