Summary | |
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Symbol | RRAS |
Name | related RAS viral (r-ras) oncogene homolog |
Aliases | Oncogene RRAS; ras family small GTP binding protein R-Ras; Ras-related protein R-Ras |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Lipid-anchor Cytoplasmic side Note=Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS). |
Domain |
PF00071 Ras family |
Function |
Regulates the organization of the actin cytoskeleton (PubMed:16537651, PubMed:18270267). With OSPBL3, modulates integrin beta-1 (ITGB1) activity (PubMed:18270267). |
Biological Process |
GO:0001525 angiogenesis GO:0002521 leukocyte differentiation GO:0007265 Ras protein signal transduction GO:0010171 body morphogenesis GO:0030336 negative regulation of cell migration GO:0040013 negative regulation of locomotion GO:0043491 protein kinase B signaling GO:0045765 regulation of angiogenesis GO:0045766 positive regulation of angiogenesis GO:0048514 blood vessel morphogenesis GO:0051271 negative regulation of cellular component movement GO:0051896 regulation of protein kinase B signaling GO:0060323 head morphogenesis GO:0060324 face development GO:0060325 face morphogenesis GO:0070371 ERK1 and ERK2 cascade GO:0070372 regulation of ERK1 and ERK2 cascade GO:1901342 regulation of vasculature development GO:1904018 positive regulation of vasculature development GO:2000146 negative regulation of cell motility |
Molecular Function |
GO:0003924 GTPase activity GO:0005525 GTP binding GO:0019001 guanyl nucleotide binding GO:0019003 GDP binding GO:0032561 guanyl ribonucleotide binding |
Cellular Component |
GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0030055 cell-substrate junction |
KEGG |
hsa04010 MAPK signaling pathway hsa04014 Ras signaling pathway hsa04015 Rap1 signaling pathway hsa04024 cAMP signaling pathway hsa04140 Regulation of autophagy hsa04360 Axon guidance hsa04810 Regulation of actin cytoskeleton |
Reactome |
R-HSA-442755: Activation of NMDA receptor upon glutamate binding and postsynaptic events R-HSA-422475: Axon guidance R-HSA-442742: CREB phosphorylation through the activation of Ras R-HSA-1266738: Developmental Biology R-HSA-112316: Neuronal System R-HSA-112314: Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell R-HSA-438064: Post NMDA receptor activation events R-HSA-399955: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-400685: Sema4D in semaphorin signaling R-HSA-416550: Sema4D mediated inhibition of cell attachment and migration R-HSA-373755: Semaphorin interactions R-HSA-112315: Transmission across Chemical Synapses |
Summary | |
---|---|
Symbol | RRAS |
Name | related RAS viral (r-ras) oncogene homolog |
Aliases | Oncogene RRAS; ras family small GTP binding protein R-Ras; Ras-related protein R-Ras |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between RRAS and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | RRAS |
Name | related RAS viral (r-ras) oncogene homolog |
Aliases | Oncogene RRAS; ras family small GTP binding protein R-Ras; Ras-related protein R-Ras |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of RRAS in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | RRAS |
Name | related RAS viral (r-ras) oncogene homolog |
Aliases | Oncogene RRAS; ras family small GTP binding protein R-Ras; Ras-related protein R-Ras |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of RRAS in various data sets.
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Points in the above scatter plot represent the mutation difference of RRAS in various data sets.
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Summary | |
---|---|
Symbol | RRAS |
Name | related RAS viral (r-ras) oncogene homolog |
Aliases | Oncogene RRAS; ras family small GTP binding protein R-Ras; Ras-related protein R-Ras |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RRAS. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | RRAS |
Name | related RAS viral (r-ras) oncogene homolog |
Aliases | Oncogene RRAS; ras family small GTP binding protein R-Ras; Ras-related protein R-Ras |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RRAS. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RRAS. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | RRAS |
Name | related RAS viral (r-ras) oncogene homolog |
Aliases | Oncogene RRAS; ras family small GTP binding protein R-Ras; Ras-related protein R-Ras |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RRAS. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | RRAS |
Name | related RAS viral (r-ras) oncogene homolog |
Aliases | Oncogene RRAS; ras family small GTP binding protein R-Ras; Ras-related protein R-Ras |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of RRAS expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | RRAS |
Name | related RAS viral (r-ras) oncogene homolog |
Aliases | Oncogene RRAS; ras family small GTP binding protein R-Ras; Ras-related protein R-Ras |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between RRAS and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | RRAS |
Name | related RAS viral (r-ras) oncogene homolog |
Aliases | Oncogene RRAS; ras family small GTP binding protein R-Ras; Ras-related protein R-Ras |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting RRAS collected from DrugBank database. |
There is no record. |