Summary | |
---|---|
Symbol | RRP36 |
Name | ribosomal RNA processing 36 |
Aliases | dJ20C7.4; C6orf153; chromosome 6 open reading frame 153; ribosomal RNA processing 36 homolog (S. cerevisiae) ...... |
Chromosomal Location | 6p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus, nucleolus Note=Concentrated in the fibrillar region of the nucleolus. |
Domain |
PF06102 Domain of unknown function (DUF947) |
Function |
Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA. |
Biological Process |
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0000469 cleavage involved in rRNA processing GO:0006364 rRNA processing GO:0016072 rRNA metabolic process GO:0022613 ribonucleoprotein complex biogenesis GO:0030490 maturation of SSU-rRNA GO:0034470 ncRNA processing GO:0042254 ribosome biogenesis GO:0042274 ribosomal small subunit biogenesis GO:0090305 nucleic acid phosphodiester bond hydrolysis GO:0090501 RNA phosphodiester bond hydrolysis |
Molecular Function | - |
Cellular Component |
GO:0030684 preribosome GO:0030686 90S preribosome |
KEGG | - |
Reactome |
R-HSA-74160: Gene Expression R-HSA-6791226: Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6790901: rRNA modification in the nucleus and cytosol R-HSA-72312: rRNA processing R-HSA-8868773: rRNA processing in the nucleus and cytosol |
Summary | |
---|---|
Symbol | RRP36 |
Name | ribosomal RNA processing 36 |
Aliases | dJ20C7.4; C6orf153; chromosome 6 open reading frame 153; ribosomal RNA processing 36 homolog (S. cerevisiae) ...... |
Chromosomal Location | 6p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between RRP36 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | RRP36 |
Name | ribosomal RNA processing 36 |
Aliases | dJ20C7.4; C6orf153; chromosome 6 open reading frame 153; ribosomal RNA processing 36 homolog (S. cerevisiae) ...... |
Chromosomal Location | 6p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of RRP36 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | RRP36 |
Name | ribosomal RNA processing 36 |
Aliases | dJ20C7.4; C6orf153; chromosome 6 open reading frame 153; ribosomal RNA processing 36 homolog (S. cerevisiae) ...... |
Chromosomal Location | 6p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of RRP36 in various data sets.
|
Points in the above scatter plot represent the mutation difference of RRP36 in various data sets.
|
Summary | |
---|---|
Symbol | RRP36 |
Name | ribosomal RNA processing 36 |
Aliases | dJ20C7.4; C6orf153; chromosome 6 open reading frame 153; ribosomal RNA processing 36 homolog (S. cerevisiae) ...... |
Chromosomal Location | 6p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RRP36. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | RRP36 |
Name | ribosomal RNA processing 36 |
Aliases | dJ20C7.4; C6orf153; chromosome 6 open reading frame 153; ribosomal RNA processing 36 homolog (S. cerevisiae) ...... |
Chromosomal Location | 6p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RRP36. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RRP36. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | RRP36 |
Name | ribosomal RNA processing 36 |
Aliases | dJ20C7.4; C6orf153; chromosome 6 open reading frame 153; ribosomal RNA processing 36 homolog (S. cerevisiae) ...... |
Chromosomal Location | 6p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RRP36. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | RRP36 |
Name | ribosomal RNA processing 36 |
Aliases | dJ20C7.4; C6orf153; chromosome 6 open reading frame 153; ribosomal RNA processing 36 homolog (S. cerevisiae) ...... |
Chromosomal Location | 6p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of RRP36 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | RRP36 |
Name | ribosomal RNA processing 36 |
Aliases | dJ20C7.4; C6orf153; chromosome 6 open reading frame 153; ribosomal RNA processing 36 homolog (S. cerevisiae) ...... |
Chromosomal Location | 6p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between RRP36 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | RRP36 |
Name | ribosomal RNA processing 36 |
Aliases | dJ20C7.4; C6orf153; chromosome 6 open reading frame 153; ribosomal RNA processing 36 homolog (S. cerevisiae) ...... |
Chromosomal Location | 6p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting RRP36 collected from DrugBank database. |
There is no record. |