Summary | |
---|---|
Symbol | RSF1 |
Name | remodeling and spacing factor 1 |
Aliases | XAP8; RSF-1; p325; HBXAP; hepatitis B virus x associated protein; HBV pX associated protein-8; HBV pX-associ ...... |
Chromosomal Location | 11q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF00628 PHD-finger PF15612 WSTF |
Function |
Required for assembly of regular nucleosome arrays by the RSF chromatin-remodeling complex (PubMed:12972596). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11944984, PubMed:11788598). |
Biological Process |
GO:0006323 DNA packaging GO:0006333 chromatin assembly or disassembly GO:0006334 nucleosome assembly GO:0006336 DNA replication-independent nucleosome assembly GO:0006338 chromatin remodeling GO:0006352 DNA-templated transcription, initiation GO:0016584 nucleosome positioning GO:0019058 viral life cycle GO:0019080 viral gene expression GO:0019083 viral transcription GO:0031055 chromatin remodeling at centromere GO:0031497 chromatin assembly GO:0034080 CENP-A containing nucleosome assembly GO:0034508 centromere complex assembly GO:0034724 DNA replication-independent nucleosome organization GO:0034728 nucleosome organization GO:0043044 ATP-dependent chromatin remodeling GO:0043392 negative regulation of DNA binding GO:0043486 histone exchange GO:0043900 regulation of multi-organism process GO:0043902 positive regulation of multi-organism process GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism GO:0044033 multi-organism metabolic process GO:0046782 regulation of viral transcription GO:0048524 positive regulation of viral process GO:0050434 positive regulation of viral transcription GO:0050792 regulation of viral process GO:0051098 regulation of binding GO:0051100 negative regulation of binding GO:0051101 regulation of DNA binding GO:0061641 CENP-A containing chromatin organization GO:0065004 protein-DNA complex assembly GO:0071103 DNA conformation change GO:0071824 protein-DNA complex subunit organization GO:1903900 regulation of viral life cycle GO:1903902 positive regulation of viral life cycle |
Molecular Function |
GO:0042393 histone binding |
Cellular Component |
GO:0031010 ISWI-type complex GO:0031213 RSF complex GO:0070603 SWI/SNF superfamily-type complex |
KEGG | - |
Reactome |
R-HSA-1640170: Cell Cycle R-HSA-73886: Chromosome Maintenance R-HSA-606279: Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-774815: Nucleosome assembly |
Summary | |
---|---|
Symbol | RSF1 |
Name | remodeling and spacing factor 1 |
Aliases | XAP8; RSF-1; p325; HBXAP; hepatitis B virus x associated protein; HBV pX associated protein-8; HBV pX-associ ...... |
Chromosomal Location | 11q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between RSF1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | RSF1 |
Name | remodeling and spacing factor 1 |
Aliases | XAP8; RSF-1; p325; HBXAP; hepatitis B virus x associated protein; HBV pX associated protein-8; HBV pX-associ ...... |
Chromosomal Location | 11q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of RSF1 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | RSF1 |
Name | remodeling and spacing factor 1 |
Aliases | XAP8; RSF-1; p325; HBXAP; hepatitis B virus x associated protein; HBV pX associated protein-8; HBV pX-associ ...... |
Chromosomal Location | 11q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of RSF1 in various data sets.
|
Points in the above scatter plot represent the mutation difference of RSF1 in various data sets.
|
Summary | |
---|---|
Symbol | RSF1 |
Name | remodeling and spacing factor 1 |
Aliases | XAP8; RSF-1; p325; HBXAP; hepatitis B virus x associated protein; HBV pX associated protein-8; HBV pX-associ ...... |
Chromosomal Location | 11q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RSF1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | RSF1 |
Name | remodeling and spacing factor 1 |
Aliases | XAP8; RSF-1; p325; HBXAP; hepatitis B virus x associated protein; HBV pX associated protein-8; HBV pX-associ ...... |
Chromosomal Location | 11q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RSF1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RSF1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | RSF1 |
Name | remodeling and spacing factor 1 |
Aliases | XAP8; RSF-1; p325; HBXAP; hepatitis B virus x associated protein; HBV pX associated protein-8; HBV pX-associ ...... |
Chromosomal Location | 11q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RSF1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | RSF1 |
Name | remodeling and spacing factor 1 |
Aliases | XAP8; RSF-1; p325; HBXAP; hepatitis B virus x associated protein; HBV pX associated protein-8; HBV pX-associ ...... |
Chromosomal Location | 11q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of RSF1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | RSF1 |
Name | remodeling and spacing factor 1 |
Aliases | XAP8; RSF-1; p325; HBXAP; hepatitis B virus x associated protein; HBV pX associated protein-8; HBV pX-associ ...... |
Chromosomal Location | 11q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between RSF1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | RSF1 |
Name | remodeling and spacing factor 1 |
Aliases | XAP8; RSF-1; p325; HBXAP; hepatitis B virus x associated protein; HBV pX associated protein-8; HBV pX-associ ...... |
Chromosomal Location | 11q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting RSF1 collected from DrugBank database. |
There is no record. |