Summary | |
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Symbol | RTP4 |
Name | receptor (chemosensory) transporter protein 4 |
Aliases | IFRG28; Z3CXXC4; zinc finger, 3CxxC-type 4; receptor transporter protein 4; 28 kDa interferon-responsive pro ...... |
Chromosomal Location | 3q27.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Single-pass type III membrane protein |
Domain |
PF13695 Zinc-binding domain |
Function |
Probable chaperone protein which facilitates trafficking and functional cell surface expression of some G-protein coupled receptors (GPCRs). Promotes functional expression of the bitter taste receptor TAS2R16 (PubMed:16720576). Also promotes functional expression of the opioid receptor heterodimer OPRD1-OPRM1 (By similarity). |
Biological Process |
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste GO:0006612 protein targeting to membrane GO:0050907 detection of chemical stimulus involved in sensory perception GO:0050909 sensory perception of taste GO:0050912 detection of chemical stimulus involved in sensory perception of taste GO:0050913 sensory perception of bitter taste GO:0051205 protein insertion into membrane GO:0072657 protein localization to membrane GO:0090150 establishment of protein localization to membrane |
Molecular Function |
GO:0001664 G-protein coupled receptor binding GO:0031849 olfactory receptor binding |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-388396: GPCR downstream signaling R-HSA-381753: Olfactory Signaling Pathway R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR |
Summary | |
---|---|
Symbol | RTP4 |
Name | receptor (chemosensory) transporter protein 4 |
Aliases | IFRG28; Z3CXXC4; zinc finger, 3CxxC-type 4; receptor transporter protein 4; 28 kDa interferon-responsive pro ...... |
Chromosomal Location | 3q27.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between RTP4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | RTP4 |
Name | receptor (chemosensory) transporter protein 4 |
Aliases | IFRG28; Z3CXXC4; zinc finger, 3CxxC-type 4; receptor transporter protein 4; 28 kDa interferon-responsive pro ...... |
Chromosomal Location | 3q27.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of RTP4 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | RTP4 |
Name | receptor (chemosensory) transporter protein 4 |
Aliases | IFRG28; Z3CXXC4; zinc finger, 3CxxC-type 4; receptor transporter protein 4; 28 kDa interferon-responsive pro ...... |
Chromosomal Location | 3q27.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of RTP4 in various data sets.
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Points in the above scatter plot represent the mutation difference of RTP4 in various data sets.
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Summary | |
---|---|
Symbol | RTP4 |
Name | receptor (chemosensory) transporter protein 4 |
Aliases | IFRG28; Z3CXXC4; zinc finger, 3CxxC-type 4; receptor transporter protein 4; 28 kDa interferon-responsive pro ...... |
Chromosomal Location | 3q27.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RTP4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | RTP4 |
Name | receptor (chemosensory) transporter protein 4 |
Aliases | IFRG28; Z3CXXC4; zinc finger, 3CxxC-type 4; receptor transporter protein 4; 28 kDa interferon-responsive pro ...... |
Chromosomal Location | 3q27.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RTP4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RTP4. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | RTP4 |
Name | receptor (chemosensory) transporter protein 4 |
Aliases | IFRG28; Z3CXXC4; zinc finger, 3CxxC-type 4; receptor transporter protein 4; 28 kDa interferon-responsive pro ...... |
Chromosomal Location | 3q27.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RTP4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | RTP4 |
Name | receptor (chemosensory) transporter protein 4 |
Aliases | IFRG28; Z3CXXC4; zinc finger, 3CxxC-type 4; receptor transporter protein 4; 28 kDa interferon-responsive pro ...... |
Chromosomal Location | 3q27.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of RTP4 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | RTP4 |
Name | receptor (chemosensory) transporter protein 4 |
Aliases | IFRG28; Z3CXXC4; zinc finger, 3CxxC-type 4; receptor transporter protein 4; 28 kDa interferon-responsive pro ...... |
Chromosomal Location | 3q27.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between RTP4 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | RTP4 |
Name | receptor (chemosensory) transporter protein 4 |
Aliases | IFRG28; Z3CXXC4; zinc finger, 3CxxC-type 4; receptor transporter protein 4; 28 kDa interferon-responsive pro ...... |
Chromosomal Location | 3q27.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting RTP4 collected from DrugBank database. |
There is no record. |