Summary | |
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Symbol | RXRG |
Name | retinoid X receptor, gamma |
Aliases | NR2B3; nuclear receptor subfamily 2 group B member 3; RXRC; Retinoid X receptor gamma; Retinoic acid recepto ...... |
Chromosomal Location | 1q22-q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF00104 Ligand-binding domain of nuclear hormone receptor PF11825 Nuclear/hormone receptor activator site AF-1 PF00105 Zinc finger |
Function |
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity). |
Biological Process |
GO:0006352 DNA-templated transcription, initiation GO:0006367 transcription initiation from RNA polymerase II promoter GO:0009755 hormone-mediated signaling pathway GO:0030522 intracellular receptor signaling pathway GO:0043401 steroid hormone mediated signaling pathway GO:0048384 retinoic acid receptor signaling pathway GO:0048545 response to steroid hormone GO:0051259 protein oligomerization GO:0051260 protein homooligomerization GO:0051262 protein tetramerization GO:0051289 protein homotetramerization GO:0071383 cellular response to steroid hormone stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus |
Molecular Function |
GO:0003707 steroid hormone receptor activity GO:0003708 retinoic acid receptor activity GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0004886 9-cis retinoic acid receptor activity GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding |
Cellular Component | - |
KEGG |
hsa03320 PPAR signaling pathway hsa04919 Thyroid hormone signaling pathway hsa04920 Adipocytokine signaling pathway |
Reactome |
R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-383280: Nuclear Receptor transcription pathway R-HSA-162582: Signal Transduction R-HSA-5362517: Signaling by Retinoic Acid |
Summary | |
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Symbol | RXRG |
Name | retinoid X receptor, gamma |
Aliases | NR2B3; nuclear receptor subfamily 2 group B member 3; RXRC; Retinoid X receptor gamma; Retinoic acid recepto ...... |
Chromosomal Location | 1q22-q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between RXRG and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | RXRG |
Name | retinoid X receptor, gamma |
Aliases | NR2B3; nuclear receptor subfamily 2 group B member 3; RXRC; Retinoid X receptor gamma; Retinoic acid recepto ...... |
Chromosomal Location | 1q22-q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of RXRG in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | RXRG |
Name | retinoid X receptor, gamma |
Aliases | NR2B3; nuclear receptor subfamily 2 group B member 3; RXRC; Retinoid X receptor gamma; Retinoic acid recepto ...... |
Chromosomal Location | 1q22-q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of RXRG in various data sets.
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Points in the above scatter plot represent the mutation difference of RXRG in various data sets.
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Summary | |
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Symbol | RXRG |
Name | retinoid X receptor, gamma |
Aliases | NR2B3; nuclear receptor subfamily 2 group B member 3; RXRC; Retinoid X receptor gamma; Retinoic acid recepto ...... |
Chromosomal Location | 1q22-q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RXRG. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | RXRG |
Name | retinoid X receptor, gamma |
Aliases | NR2B3; nuclear receptor subfamily 2 group B member 3; RXRC; Retinoid X receptor gamma; Retinoic acid recepto ...... |
Chromosomal Location | 1q22-q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RXRG. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RXRG. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | RXRG |
Name | retinoid X receptor, gamma |
Aliases | NR2B3; nuclear receptor subfamily 2 group B member 3; RXRC; Retinoid X receptor gamma; Retinoic acid recepto ...... |
Chromosomal Location | 1q22-q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RXRG. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | RXRG |
Name | retinoid X receptor, gamma |
Aliases | NR2B3; nuclear receptor subfamily 2 group B member 3; RXRC; Retinoid X receptor gamma; Retinoic acid recepto ...... |
Chromosomal Location | 1q22-q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of RXRG expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | RXRG |
Name | retinoid X receptor, gamma |
Aliases | NR2B3; nuclear receptor subfamily 2 group B member 3; RXRC; Retinoid X receptor gamma; Retinoic acid recepto ...... |
Chromosomal Location | 1q22-q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between RXRG and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | RXRG |
Name | retinoid X receptor, gamma |
Aliases | NR2B3; nuclear receptor subfamily 2 group B member 3; RXRC; Retinoid X receptor gamma; Retinoic acid recepto ...... |
Chromosomal Location | 1q22-q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting RXRG collected from DrugBank database. |
Details on drugs targeting RXRG.
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