Browse S100A1

Summary
SymbolS100A1
NameS100 calcium binding protein A1
Aliases S100-alpha; S100A; S100 calcium-binding protein A1; S-100 protein alpha chain; S-100 protein subunit alpha; ......
Chromosomal Location1q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm
Domain PF00036 EF hand
PF01023 S-100/ICaBP type calcium binding domain
Function

Probably acts as a Ca(2+) signal transducer (PubMed:22399290). In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers a conformational change (PubMed:23351007). This conformational change allows interaction of S1001A with specific target proteins, such as TPR-containing proteins, and the modulation of their activity (PubMed:22399290).

> Gene Ontology
 
Biological Process GO:0003013 circulatory system process
GO:0003015 heart process
GO:0006816 calcium ion transport
GO:0008015 blood circulation
GO:0008016 regulation of heart contraction
GO:0010959 regulation of metal ion transport
GO:0021762 substantia nigra development
GO:0022898 regulation of transmembrane transporter activity
GO:0030901 midbrain development
GO:0032409 regulation of transporter activity
GO:0032411 positive regulation of transporter activity
GO:0032412 regulation of ion transmembrane transporter activity
GO:0032414 positive regulation of ion transmembrane transporter activity
GO:0034762 regulation of transmembrane transport
GO:0034764 positive regulation of transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0034767 positive regulation of ion transmembrane transport
GO:0043270 positive regulation of ion transport
GO:0044057 regulation of system process
GO:0048857 neural nucleus development
GO:0051924 regulation of calcium ion transport
GO:0051928 positive regulation of calcium ion transport
GO:0060047 heart contraction
GO:0070588 calcium ion transmembrane transport
GO:0070838 divalent metal ion transport
GO:0072511 divalent inorganic cation transport
GO:1901019 regulation of calcium ion transmembrane transporter activity
GO:1901021 positive regulation of calcium ion transmembrane transporter activity
GO:1901385 regulation of voltage-gated calcium channel activity
GO:1901387 positive regulation of voltage-gated calcium channel activity
GO:1903169 regulation of calcium ion transmembrane transport
GO:1903522 regulation of blood circulation
GO:1904062 regulation of cation transmembrane transport
GO:1904064 positive regulation of cation transmembrane transport
GO:1904427 positive regulation of calcium ion transmembrane transport
GO:2001257 regulation of cation channel activity
GO:2001259 positive regulation of cation channel activity
Molecular Function GO:0044548 S100 protein binding
GO:0048306 calcium-dependent protein binding
GO:0051117 ATPase binding
Cellular Component GO:0016528 sarcoplasm
GO:0016529 sarcoplasmic reticulum
GO:0030016 myofibril
GO:0030017 sarcomere
GO:0030018 Z disc
GO:0031430 M band
GO:0031672 A band
GO:0031674 I band
GO:0043292 contractile fiber
GO:0044449 contractile fiber part
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-5686938: Regulation of TLR by endogenous ligand
R-HSA-168898: Toll-Like Receptors Cascades
Summary
SymbolS100A1
NameS100 calcium binding protein A1
Aliases S100-alpha; S100A; S100 calcium-binding protein A1; S-100 protein alpha chain; S-100 protein subunit alpha; ......
Chromosomal Location1q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between S100A1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between S100A1 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
16899613Bladder carcinomaPromote immunityImmunohistochemical staining for HLA class I, CD4, CD8, CD20, CD68, TIA-1, S-100, and FOXP3 was carried out on specimens from 30 patients who underwent BCG immunotherapy from whom both pretreatment and posttreatment specimens were obtained. Our data show that expression of HLA class I molecules on tumor cells contributes significantly to the therapeutic effect of BCG immunotherapy for bladder cancer. It is suggested that CTLs may be one of main effectors in this therapy.
Summary
SymbolS100A1
NameS100 calcium binding protein A1
Aliases S100-alpha; S100A; S100 calcium-binding protein A1; S-100 protein alpha chain; S-100 protein subunit alpha; ......
Chromosomal Location1q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of S100A1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolS100A1
NameS100 calcium binding protein A1
Aliases S100-alpha; S100A; S100 calcium-binding protein A1; S-100 protein alpha chain; S-100 protein subunit alpha; ......
Chromosomal Location1q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of S100A1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14121.0120.337
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.4340.926
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)872.0870.514
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.6410.327
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.070.961
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 471.3580.411
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1410.833
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.5430.794
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.7930.744
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.7880.757
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-2.3820.546
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.5340.0438
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of S100A1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolS100A1
NameS100 calcium binding protein A1
Aliases S100-alpha; S100A; S100 calcium-binding protein A1; S-100 protein alpha chain; S-100 protein subunit alpha; ......
Chromosomal Location1q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of S100A1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolS100A1
NameS100 calcium binding protein A1
Aliases S100-alpha; S100A; S100 calcium-binding protein A1; S-100 protein alpha chain; S-100 protein subunit alpha; ......
Chromosomal Location1q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of S100A1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by S100A1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolS100A1
NameS100 calcium binding protein A1
Aliases S100-alpha; S100A; S100 calcium-binding protein A1; S-100 protein alpha chain; S-100 protein subunit alpha; ......
Chromosomal Location1q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of S100A1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolS100A1
NameS100 calcium binding protein A1
Aliases S100-alpha; S100A; S100 calcium-binding protein A1; S-100 protein alpha chain; S-100 protein subunit alpha; ......
Chromosomal Location1q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of S100A1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolS100A1
NameS100 calcium binding protein A1
Aliases S100-alpha; S100A; S100 calcium-binding protein A1; S-100 protein alpha chain; S-100 protein subunit alpha; ......
Chromosomal Location1q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between S100A1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolS100A1
NameS100 calcium binding protein A1
Aliases S100-alpha; S100A; S100 calcium-binding protein A1; S-100 protein alpha chain; S-100 protein subunit alpha; ......
Chromosomal Location1q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting S100A1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting S100A1.
ID Name Drug Type Targets #Targets
DB00768OlopatadineSmall MoleculeHRH1, S100A1, S100A12, S100A13, S100A2, S100B6