Browse S100A6

Summary
SymbolS100A6
NameS100 calcium binding protein A6
Aliases 2A9; PRA; CACY; S100 calcium-binding protein A6 (calcyclin); S100 calcium binding protein A6 (calcyclin); 5B ......
Chromosomal Location1q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus envelope. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Domain PF01023 S-100/ICaBP type calcium binding domain
Function

May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative.

> Gene Ontology
 
Biological Process GO:0007409 axonogenesis
GO:0048144 fibroblast proliferation
GO:0048145 regulation of fibroblast proliferation
GO:0048146 positive regulation of fibroblast proliferation
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0061564 axon development
Molecular Function GO:0005523 tropomyosin binding
GO:0044548 S100 protein binding
GO:0048306 calcium-dependent protein binding
Cellular Component GO:0001726 ruffle
GO:0005635 nuclear envelope
GO:0009898 cytoplasmic side of plasma membrane
GO:0019897 extrinsic component of plasma membrane
GO:0019898 extrinsic component of membrane
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031252 cell leading edge
GO:0098552 side of membrane
GO:0098562 cytoplasmic side of membrane
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolS100A6
NameS100 calcium binding protein A6
Aliases 2A9; PRA; CACY; S100 calcium-binding protein A6 (calcyclin); S100 calcium binding protein A6 (calcyclin); 5B ......
Chromosomal Location1q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between S100A6 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between S100A6 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
28646023Acute Lymphoblastic LeukemiaInhibit immunity; Resistant to immunotherapyAmlexanox Downregulates S100A6 to SensitizeKMT2A/AFF1-Positive Acute Lymphoblastic Leukemia to TNFα Treatment. In KMT2A/AFF1-positive transgenic (Tg) mice, amlexanox enhanced tumor immunity and lowered the penetrance of leukemia development. Similarly, in a NOD/SCID mouse model of humanKMT2A/AFF1-positive ALL, amlexanox broadened GVL responses and extended survival.
Summary
SymbolS100A6
NameS100 calcium binding protein A6
Aliases 2A9; PRA; CACY; S100 calcium-binding protein A6 (calcyclin); S100 calcium binding protein A6 (calcyclin); 5B ......
Chromosomal Location1q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of S100A6 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolS100A6
NameS100 calcium binding protein A6
Aliases 2A9; PRA; CACY; S100 calcium-binding protein A6 (calcyclin); S100 calcium binding protein A6 (calcyclin); 5B ......
Chromosomal Location1q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of S100A6 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-1.4470.0481
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.7290.733
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-1.2120.711
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9161.0570.166
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 591.0640.695
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 471.0530.767
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0850.902
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.7080.763
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.4960.856
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.920.776
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.2690.799
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0460.784
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of S100A6 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolS100A6
NameS100 calcium binding protein A6
Aliases 2A9; PRA; CACY; S100 calcium-binding protein A6 (calcyclin); S100 calcium binding protein A6 (calcyclin); 5B ......
Chromosomal Location1q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of S100A6. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolS100A6
NameS100 calcium binding protein A6
Aliases 2A9; PRA; CACY; S100 calcium-binding protein A6 (calcyclin); S100 calcium binding protein A6 (calcyclin); 5B ......
Chromosomal Location1q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of S100A6. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by S100A6.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolS100A6
NameS100 calcium binding protein A6
Aliases 2A9; PRA; CACY; S100 calcium-binding protein A6 (calcyclin); S100 calcium binding protein A6 (calcyclin); 5B ......
Chromosomal Location1q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of S100A6. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolS100A6
NameS100 calcium binding protein A6
Aliases 2A9; PRA; CACY; S100 calcium-binding protein A6 (calcyclin); S100 calcium binding protein A6 (calcyclin); 5B ......
Chromosomal Location1q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of S100A6 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolS100A6
NameS100 calcium binding protein A6
Aliases 2A9; PRA; CACY; S100 calcium-binding protein A6 (calcyclin); S100 calcium binding protein A6 (calcyclin); 5B ......
Chromosomal Location1q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between S100A6 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolS100A6
NameS100 calcium binding protein A6
Aliases 2A9; PRA; CACY; S100 calcium-binding protein A6 (calcyclin); S100 calcium binding protein A6 (calcyclin); 5B ......
Chromosomal Location1q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting S100A6 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting S100A6.
ID Name Drug Type Targets #Targets
DB11093Calcium CitrateSmall MoleculeCADPS, CADPS2, CALB2, CALR, CALR3, CANX, CAPS, CASQ1, CASQ2, CASR, ......29
DB11348Calcium PhosphateSmall MoleculeCADPS, CADPS2, CALB2, CALR, CALR3, CANX, CAPS, CASQ1, CASQ2, CASR, ......29