Summary | |
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Symbol | S100A6 |
Name | S100 calcium binding protein A6 |
Aliases | 2A9; PRA; CACY; S100 calcium-binding protein A6 (calcyclin); S100 calcium binding protein A6 (calcyclin); 5B ...... |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus envelope. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. |
Domain |
PF01023 S-100/ICaBP type calcium binding domain |
Function |
May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative. |
Biological Process |
GO:0007409 axonogenesis GO:0048144 fibroblast proliferation GO:0048145 regulation of fibroblast proliferation GO:0048146 positive regulation of fibroblast proliferation GO:0048667 cell morphogenesis involved in neuron differentiation GO:0061564 axon development |
Molecular Function |
GO:0005523 tropomyosin binding GO:0044548 S100 protein binding GO:0048306 calcium-dependent protein binding |
Cellular Component |
GO:0001726 ruffle GO:0005635 nuclear envelope GO:0009898 cytoplasmic side of plasma membrane GO:0019897 extrinsic component of plasma membrane GO:0019898 extrinsic component of membrane GO:0031234 extrinsic component of cytoplasmic side of plasma membrane GO:0031252 cell leading edge GO:0098552 side of membrane GO:0098562 cytoplasmic side of membrane |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | S100A6 |
Name | S100 calcium binding protein A6 |
Aliases | 2A9; PRA; CACY; S100 calcium-binding protein A6 (calcyclin); S100 calcium binding protein A6 (calcyclin); 5B ...... |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between S100A6 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between S100A6 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | S100A6 |
Name | S100 calcium binding protein A6 |
Aliases | 2A9; PRA; CACY; S100 calcium-binding protein A6 (calcyclin); S100 calcium binding protein A6 (calcyclin); 5B ...... |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of S100A6 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | S100A6 |
Name | S100 calcium binding protein A6 |
Aliases | 2A9; PRA; CACY; S100 calcium-binding protein A6 (calcyclin); S100 calcium binding protein A6 (calcyclin); 5B ...... |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of S100A6 in various data sets.
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Points in the above scatter plot represent the mutation difference of S100A6 in various data sets.
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Summary | |
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Symbol | S100A6 |
Name | S100 calcium binding protein A6 |
Aliases | 2A9; PRA; CACY; S100 calcium-binding protein A6 (calcyclin); S100 calcium binding protein A6 (calcyclin); 5B ...... |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of S100A6. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | S100A6 |
Name | S100 calcium binding protein A6 |
Aliases | 2A9; PRA; CACY; S100 calcium-binding protein A6 (calcyclin); S100 calcium binding protein A6 (calcyclin); 5B ...... |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of S100A6. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by S100A6. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | S100A6 |
Name | S100 calcium binding protein A6 |
Aliases | 2A9; PRA; CACY; S100 calcium-binding protein A6 (calcyclin); S100 calcium binding protein A6 (calcyclin); 5B ...... |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of S100A6. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | S100A6 |
Name | S100 calcium binding protein A6 |
Aliases | 2A9; PRA; CACY; S100 calcium-binding protein A6 (calcyclin); S100 calcium binding protein A6 (calcyclin); 5B ...... |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of S100A6 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | S100A6 |
Name | S100 calcium binding protein A6 |
Aliases | 2A9; PRA; CACY; S100 calcium-binding protein A6 (calcyclin); S100 calcium binding protein A6 (calcyclin); 5B ...... |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between S100A6 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | S100A6 |
Name | S100 calcium binding protein A6 |
Aliases | 2A9; PRA; CACY; S100 calcium-binding protein A6 (calcyclin); S100 calcium binding protein A6 (calcyclin); 5B ...... |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting S100A6 collected from DrugBank database. |
Details on drugs targeting S100A6.
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