Summary | |
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Symbol | S1PR1 |
Name | sphingosine-1-phosphate receptor 1 |
Aliases | edg-1; D1S3362; CD363; endothelial differentiation, sphingolipid G-protein-coupled receptor, 1; CHEDG1; S1P1 ...... |
Chromosomal Location | 1p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Multi-pass membrane protein. Endosome. Membrane raft. Note=Recruited to caveolin-enriched plasma membrane microdomains in response to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine. Ligand binding leads to receptor internalization. |
Domain |
PF00001 7 transmembrane receptor (rhodopsin family) |
Function |
G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury. |
Biological Process |
GO:0001503 ossification GO:0001525 angiogenesis GO:0001894 tissue homeostasis GO:0001955 blood vessel maturation GO:0003007 heart morphogenesis GO:0003158 endothelium development GO:0003241 growth involved in heart morphogenesis GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis GO:0003376 sphingosine-1-phosphate signaling pathway GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0007015 actin filament organization GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0007507 heart development GO:0007517 muscle organ development GO:0010639 negative regulation of organelle organization GO:0014706 striated muscle tissue development GO:0019226 transmission of nerve impulse GO:0021700 developmental maturation GO:0030031 cell projection assembly GO:0030032 lamellipodium assembly GO:0030038 contractile actin filament bundle assembly GO:0030278 regulation of ossification GO:0030282 bone mineralization GO:0030335 positive regulation of cell migration GO:0030500 regulation of bone mineralization GO:0030595 leukocyte chemotaxis GO:0031032 actomyosin structure organization GO:0031214 biomineral tissue development GO:0031532 actin cytoskeleton reorganization GO:0032103 positive regulation of response to external stimulus GO:0032231 regulation of actin filament bundle assembly GO:0032232 negative regulation of actin filament bundle assembly GO:0032844 regulation of homeostatic process GO:0032956 regulation of actin cytoskeleton organization GO:0032970 regulation of actin filament-based process GO:0033002 muscle cell proliferation GO:0034103 regulation of tissue remodeling GO:0035265 organ growth GO:0035637 multicellular organismal signaling GO:0040017 positive regulation of locomotion GO:0043149 stress fiber assembly GO:0045124 regulation of bone resorption GO:0045446 endothelial cell differentiation GO:0045453 bone resorption GO:0046849 bone remodeling GO:0046850 regulation of bone remodeling GO:0048514 blood vessel morphogenesis GO:0048644 muscle organ morphogenesis GO:0048659 smooth muscle cell proliferation GO:0048660 regulation of smooth muscle cell proliferation GO:0048661 positive regulation of smooth muscle cell proliferation GO:0048738 cardiac muscle tissue development GO:0048771 tissue remodeling GO:0048871 multicellular organismal homeostasis GO:0050900 leukocyte migration GO:0050918 positive chemotaxis GO:0050920 regulation of chemotaxis GO:0050921 positive regulation of chemotaxis GO:0050926 regulation of positive chemotaxis GO:0050927 positive regulation of positive chemotaxis GO:0051017 actin filament bundle assembly GO:0051272 positive regulation of cellular component movement GO:0051480 regulation of cytosolic calcium ion concentration GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway GO:0051492 regulation of stress fiber assembly GO:0051493 regulation of cytoskeleton organization GO:0051494 negative regulation of cytoskeleton organization GO:0051497 negative regulation of stress fiber assembly GO:0055008 cardiac muscle tissue morphogenesis GO:0055017 cardiac muscle tissue growth GO:0055074 calcium ion homeostasis GO:0060249 anatomical structure homeostasis GO:0060326 cell chemotaxis GO:0060415 muscle tissue morphogenesis GO:0060419 heart growth GO:0060537 muscle tissue development GO:0060560 developmental growth involved in morphogenesis GO:0061383 trabecula morphogenesis GO:0061384 heart trabecula morphogenesis GO:0061572 actin filament bundle organization GO:0070167 regulation of biomineral tissue development GO:0071695 anatomical structure maturation GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0072676 lymphocyte migration GO:0072678 T cell migration GO:0090520 sphingolipid mediated signaling pathway GO:0097581 lamellipodium organization GO:2000147 positive regulation of cell motility |
Molecular Function |
GO:0001664 G-protein coupled receptor binding GO:0038036 sphingosine-1-phosphate receptor activity GO:0045125 bioactive lipid receptor activity GO:0046625 sphingolipid binding |
Cellular Component |
GO:0009897 external side of plasma membrane GO:0045121 membrane raft GO:0098552 side of membrane GO:0098589 membrane region GO:0098857 membrane microdomain |
KEGG |
hsa04068 FoxO signaling pathway hsa04071 Sphingolipid signaling pathway hsa04080 Neuroactive ligand-receptor interaction |
Reactome |
R-HSA-373076: Class A/1 (Rhodopsin-like receptors) R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-418594: G alpha (i) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-168256: Immune System R-HSA-6785807: Interleukin-4 and 13 signaling R-HSA-419408: Lysosphingolipid and LPA receptors R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR R-HSA-449147: Signaling by Interleukins |
Summary | |
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Symbol | S1PR1 |
Name | sphingosine-1-phosphate receptor 1 |
Aliases | edg-1; D1S3362; CD363; endothelial differentiation, sphingolipid G-protein-coupled receptor, 1; CHEDG1; S1P1 ...... |
Chromosomal Location | 1p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between S1PR1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between S1PR1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | S1PR1 |
Name | sphingosine-1-phosphate receptor 1 |
Aliases | edg-1; D1S3362; CD363; endothelial differentiation, sphingolipid G-protein-coupled receptor, 1; CHEDG1; S1P1 ...... |
Chromosomal Location | 1p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of S1PR1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | S1PR1 |
Name | sphingosine-1-phosphate receptor 1 |
Aliases | edg-1; D1S3362; CD363; endothelial differentiation, sphingolipid G-protein-coupled receptor, 1; CHEDG1; S1P1 ...... |
Chromosomal Location | 1p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of S1PR1 in various data sets.
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Points in the above scatter plot represent the mutation difference of S1PR1 in various data sets.
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Summary | |
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Symbol | S1PR1 |
Name | sphingosine-1-phosphate receptor 1 |
Aliases | edg-1; D1S3362; CD363; endothelial differentiation, sphingolipid G-protein-coupled receptor, 1; CHEDG1; S1P1 ...... |
Chromosomal Location | 1p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of S1PR1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | S1PR1 |
Name | sphingosine-1-phosphate receptor 1 |
Aliases | edg-1; D1S3362; CD363; endothelial differentiation, sphingolipid G-protein-coupled receptor, 1; CHEDG1; S1P1 ...... |
Chromosomal Location | 1p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of S1PR1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by S1PR1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | S1PR1 |
Name | sphingosine-1-phosphate receptor 1 |
Aliases | edg-1; D1S3362; CD363; endothelial differentiation, sphingolipid G-protein-coupled receptor, 1; CHEDG1; S1P1 ...... |
Chromosomal Location | 1p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of S1PR1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | S1PR1 |
Name | sphingosine-1-phosphate receptor 1 |
Aliases | edg-1; D1S3362; CD363; endothelial differentiation, sphingolipid G-protein-coupled receptor, 1; CHEDG1; S1P1 ...... |
Chromosomal Location | 1p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of S1PR1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | S1PR1 |
Name | sphingosine-1-phosphate receptor 1 |
Aliases | edg-1; D1S3362; CD363; endothelial differentiation, sphingolipid G-protein-coupled receptor, 1; CHEDG1; S1P1 ...... |
Chromosomal Location | 1p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between S1PR1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | S1PR1 |
Name | sphingosine-1-phosphate receptor 1 |
Aliases | edg-1; D1S3362; CD363; endothelial differentiation, sphingolipid G-protein-coupled receptor, 1; CHEDG1; S1P1 ...... |
Chromosomal Location | 1p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting S1PR1 collected from DrugBank database. |
Details on drugs targeting S1PR1.
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