Summary | |
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Symbol | S1PR4 |
Name | sphingosine-1-phosphate receptor 4 |
Aliases | EDG6; endothelial differentiation, G-protein-coupled receptor 6; endothelial differentiation, lysophosphatid ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Domain |
PF00001 7 transmembrane receptor (rhodopsin family) |
Function |
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes. |
Biological Process |
GO:0003376 sphingosine-1-phosphate signaling pathway GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007202 activation of phospholipase C activity GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0010517 regulation of phospholipase activity GO:0010518 positive regulation of phospholipase activity GO:0010863 positive regulation of phospholipase C activity GO:0051480 regulation of cytosolic calcium ion concentration GO:0055074 calcium ion homeostasis GO:0060191 regulation of lipase activity GO:0060193 positive regulation of lipase activity GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0090520 sphingolipid mediated signaling pathway GO:1900274 regulation of phospholipase C activity |
Molecular Function |
GO:0038036 sphingosine-1-phosphate receptor activity GO:0045125 bioactive lipid receptor activity |
Cellular Component | - |
KEGG |
hsa04068 FoxO signaling pathway hsa04071 Sphingolipid signaling pathway hsa04080 Neuroactive ligand-receptor interaction |
Reactome |
R-HSA-373076: Class A/1 (Rhodopsin-like receptors) R-HSA-418594: G alpha (i) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-419408: Lysosphingolipid and LPA receptors R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR |
Summary | |
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Symbol | S1PR4 |
Name | sphingosine-1-phosphate receptor 4 |
Aliases | EDG6; endothelial differentiation, G-protein-coupled receptor 6; endothelial differentiation, lysophosphatid ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between S1PR4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between S1PR4 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | S1PR4 |
Name | sphingosine-1-phosphate receptor 4 |
Aliases | EDG6; endothelial differentiation, G-protein-coupled receptor 6; endothelial differentiation, lysophosphatid ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of S1PR4 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | S1PR4 |
Name | sphingosine-1-phosphate receptor 4 |
Aliases | EDG6; endothelial differentiation, G-protein-coupled receptor 6; endothelial differentiation, lysophosphatid ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of S1PR4 in various data sets.
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Points in the above scatter plot represent the mutation difference of S1PR4 in various data sets.
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Summary | |
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Symbol | S1PR4 |
Name | sphingosine-1-phosphate receptor 4 |
Aliases | EDG6; endothelial differentiation, G-protein-coupled receptor 6; endothelial differentiation, lysophosphatid ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of S1PR4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | S1PR4 |
Name | sphingosine-1-phosphate receptor 4 |
Aliases | EDG6; endothelial differentiation, G-protein-coupled receptor 6; endothelial differentiation, lysophosphatid ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of S1PR4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by S1PR4. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | S1PR4 |
Name | sphingosine-1-phosphate receptor 4 |
Aliases | EDG6; endothelial differentiation, G-protein-coupled receptor 6; endothelial differentiation, lysophosphatid ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of S1PR4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | S1PR4 |
Name | sphingosine-1-phosphate receptor 4 |
Aliases | EDG6; endothelial differentiation, G-protein-coupled receptor 6; endothelial differentiation, lysophosphatid ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of S1PR4 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | S1PR4 |
Name | sphingosine-1-phosphate receptor 4 |
Aliases | EDG6; endothelial differentiation, G-protein-coupled receptor 6; endothelial differentiation, lysophosphatid ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between S1PR4 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | S1PR4 |
Name | sphingosine-1-phosphate receptor 4 |
Aliases | EDG6; endothelial differentiation, G-protein-coupled receptor 6; endothelial differentiation, lysophosphatid ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting S1PR4 collected from DrugBank database. |
There is no record. |