Summary | |
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Symbol | SACM1L |
Name | SAC1 suppressor of actin mutations 1-like (yeast) |
Aliases | SAC1; KIAA0851; suppressor of actin 1; suppressor of actin mutations 1-like protein; Phosphatidylinositide p ...... |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Endoplasmic reticulum membrane Multi-pass membrane protein |
Domain |
PF02383 SacI homology domain |
Function |
Phosphoinositide phosphatase that hydrolyzes phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 4-phosphate (PtdIns(4)P) (PubMed:24209621). Has low activity towards PtdIns(3,5)P2 (By similarity). |
Biological Process |
GO:0006644 phospholipid metabolic process GO:0006650 glycerophospholipid metabolic process GO:0006661 phosphatidylinositol biosynthetic process GO:0008654 phospholipid biosynthetic process GO:0016311 dephosphorylation GO:0030258 lipid modification GO:0045017 glycerolipid biosynthetic process GO:0046474 glycerophospholipid biosynthetic process GO:0046486 glycerolipid metabolic process GO:0046488 phosphatidylinositol metabolic process GO:0046839 phospholipid dephosphorylation GO:0046856 phosphatidylinositol dephosphorylation |
Molecular Function |
GO:0004438 phosphatidylinositol-3-phosphatase activity GO:0016791 phosphatase activity GO:0034593 phosphatidylinositol bisphosphate phosphatase activity GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity GO:0042578 phosphoric ester hydrolase activity GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity GO:0052744 phosphatidylinositol monophosphate phosphatase activity GO:0052866 phosphatidylinositol phosphate phosphatase activity |
Cellular Component |
GO:0008328 ionotropic glutamate receptor complex GO:0030176 integral component of endoplasmic reticulum membrane GO:0031227 intrinsic component of endoplasmic reticulum membrane GO:0032281 AMPA glutamate receptor complex GO:0034702 ion channel complex GO:0043235 receptor complex GO:0098802 plasma membrane receptor complex GO:0098878 neurotransmitter receptor complex GO:1902495 transmembrane transporter complex GO:1990351 transporter complex |
KEGG | - |
Reactome |
R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-1483255: PI Metabolism R-HSA-1483257: Phospholipid metabolism R-HSA-1483248: Synthesis of PIPs at the ER membrane R-HSA-1660514: Synthesis of PIPs at the Golgi membrane |
Summary | |
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Symbol | SACM1L |
Name | SAC1 suppressor of actin mutations 1-like (yeast) |
Aliases | SAC1; KIAA0851; suppressor of actin 1; suppressor of actin mutations 1-like protein; Phosphatidylinositide p ...... |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SACM1L and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SACM1L |
Name | SAC1 suppressor of actin mutations 1-like (yeast) |
Aliases | SAC1; KIAA0851; suppressor of actin 1; suppressor of actin mutations 1-like protein; Phosphatidylinositide p ...... |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SACM1L in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SACM1L |
Name | SAC1 suppressor of actin mutations 1-like (yeast) |
Aliases | SAC1; KIAA0851; suppressor of actin 1; suppressor of actin mutations 1-like protein; Phosphatidylinositide p ...... |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SACM1L in various data sets.
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Points in the above scatter plot represent the mutation difference of SACM1L in various data sets.
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Summary | |
---|---|
Symbol | SACM1L |
Name | SAC1 suppressor of actin mutations 1-like (yeast) |
Aliases | SAC1; KIAA0851; suppressor of actin 1; suppressor of actin mutations 1-like protein; Phosphatidylinositide p ...... |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SACM1L. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | SACM1L |
Name | SAC1 suppressor of actin mutations 1-like (yeast) |
Aliases | SAC1; KIAA0851; suppressor of actin 1; suppressor of actin mutations 1-like protein; Phosphatidylinositide p ...... |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SACM1L. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SACM1L. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | SACM1L |
Name | SAC1 suppressor of actin mutations 1-like (yeast) |
Aliases | SAC1; KIAA0851; suppressor of actin 1; suppressor of actin mutations 1-like protein; Phosphatidylinositide p ...... |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SACM1L. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | SACM1L |
Name | SAC1 suppressor of actin mutations 1-like (yeast) |
Aliases | SAC1; KIAA0851; suppressor of actin 1; suppressor of actin mutations 1-like protein; Phosphatidylinositide p ...... |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SACM1L expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SACM1L |
Name | SAC1 suppressor of actin mutations 1-like (yeast) |
Aliases | SAC1; KIAA0851; suppressor of actin 1; suppressor of actin mutations 1-like protein; Phosphatidylinositide p ...... |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SACM1L and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SACM1L |
Name | SAC1 suppressor of actin mutations 1-like (yeast) |
Aliases | SAC1; KIAA0851; suppressor of actin 1; suppressor of actin mutations 1-like protein; Phosphatidylinositide p ...... |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SACM1L collected from DrugBank database. |
There is no record. |