Browse SACM1L

Summary
SymbolSACM1L
NameSAC1 suppressor of actin mutations 1-like (yeast)
Aliases SAC1; KIAA0851; suppressor of actin 1; suppressor of actin mutations 1-like protein; Phosphatidylinositide p ......
Chromosomal Location3p21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Endoplasmic reticulum membrane Multi-pass membrane protein
Domain PF02383 SacI homology domain
Function

Phosphoinositide phosphatase that hydrolyzes phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 4-phosphate (PtdIns(4)P) (PubMed:24209621). Has low activity towards PtdIns(3,5)P2 (By similarity).

> Gene Ontology
 
Biological Process GO:0006644 phospholipid metabolic process
GO:0006650 glycerophospholipid metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0008654 phospholipid biosynthetic process
GO:0016311 dephosphorylation
GO:0030258 lipid modification
GO:0045017 glycerolipid biosynthetic process
GO:0046474 glycerophospholipid biosynthetic process
GO:0046486 glycerolipid metabolic process
GO:0046488 phosphatidylinositol metabolic process
GO:0046839 phospholipid dephosphorylation
GO:0046856 phosphatidylinositol dephosphorylation
Molecular Function GO:0004438 phosphatidylinositol-3-phosphatase activity
GO:0016791 phosphatase activity
GO:0034593 phosphatidylinositol bisphosphate phosphatase activity
GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity
GO:0042578 phosphoric ester hydrolase activity
GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity
GO:0052744 phosphatidylinositol monophosphate phosphatase activity
GO:0052866 phosphatidylinositol phosphate phosphatase activity
Cellular Component GO:0008328 ionotropic glutamate receptor complex
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0031227 intrinsic component of endoplasmic reticulum membrane
GO:0032281 AMPA glutamate receptor complex
GO:0034702 ion channel complex
GO:0043235 receptor complex
GO:0098802 plasma membrane receptor complex
GO:0098878 neurotransmitter receptor complex
GO:1902495 transmembrane transporter complex
GO:1990351 transporter complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-1430728: Metabolism
R-HSA-556833: Metabolism of lipids and lipoproteins
R-HSA-1483255: PI Metabolism
R-HSA-1483257: Phospholipid metabolism
R-HSA-1483248: Synthesis of PIPs at the ER membrane
R-HSA-1660514: Synthesis of PIPs at the Golgi membrane
Summary
SymbolSACM1L
NameSAC1 suppressor of actin mutations 1-like (yeast)
Aliases SAC1; KIAA0851; suppressor of actin 1; suppressor of actin mutations 1-like protein; Phosphatidylinositide p ......
Chromosomal Location3p21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SACM1L and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolSACM1L
NameSAC1 suppressor of actin mutations 1-like (yeast)
Aliases SAC1; KIAA0851; suppressor of actin 1; suppressor of actin mutations 1-like protein; Phosphatidylinositide p ......
Chromosomal Location3p21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SACM1L in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolSACM1L
NameSAC1 suppressor of actin mutations 1-like (yeast)
Aliases SAC1; KIAA0851; suppressor of actin 1; suppressor of actin mutations 1-like protein; Phosphatidylinositide p ......
Chromosomal Location3p21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SACM1L in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1190.69
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.2360.904
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.040.977
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0350.909
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.1650.919
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.2870.887
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.1680.643
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.240.894
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.0650.974
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.0130.99
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.7020.664
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0020.966
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of SACM1L in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.1011.10.0181
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.1011.10.0286
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolSACM1L
NameSAC1 suppressor of actin mutations 1-like (yeast)
Aliases SAC1; KIAA0851; suppressor of actin 1; suppressor of actin mutations 1-like protein; Phosphatidylinositide p ......
Chromosomal Location3p21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SACM1L. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSACM1L
NameSAC1 suppressor of actin mutations 1-like (yeast)
Aliases SAC1; KIAA0851; suppressor of actin 1; suppressor of actin mutations 1-like protein; Phosphatidylinositide p ......
Chromosomal Location3p21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SACM1L. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SACM1L.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSACM1L
NameSAC1 suppressor of actin mutations 1-like (yeast)
Aliases SAC1; KIAA0851; suppressor of actin 1; suppressor of actin mutations 1-like protein; Phosphatidylinositide p ......
Chromosomal Location3p21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SACM1L. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSACM1L
NameSAC1 suppressor of actin mutations 1-like (yeast)
Aliases SAC1; KIAA0851; suppressor of actin 1; suppressor of actin mutations 1-like protein; Phosphatidylinositide p ......
Chromosomal Location3p21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SACM1L expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSACM1L
NameSAC1 suppressor of actin mutations 1-like (yeast)
Aliases SAC1; KIAA0851; suppressor of actin 1; suppressor of actin mutations 1-like protein; Phosphatidylinositide p ......
Chromosomal Location3p21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SACM1L and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSACM1L
NameSAC1 suppressor of actin mutations 1-like (yeast)
Aliases SAC1; KIAA0851; suppressor of actin 1; suppressor of actin mutations 1-like protein; Phosphatidylinositide p ......
Chromosomal Location3p21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SACM1L collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.