Summary | |
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Symbol | SAFB |
Name | scaffold attachment factor B |
Aliases | SAFB1; Hsp27 ERE-TATA binding protein; SAF-B11; HSP27 ERE-TATA-binding protein; HSP27 estrogen response elem ...... |
Chromosomal Location | 19p13.3-p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF00076 RNA recognition motif. (a.k.a. RRM PF02037 SAP domain |
Function |
Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (By similarity). Can function as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription. When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). Can inhibit cell proliferation. |
Biological Process |
GO:0006397 mRNA processing GO:0009755 hormone-mediated signaling pathway GO:0010817 regulation of hormone levels GO:0030518 intracellular steroid hormone receptor signaling pathway GO:0030520 intracellular estrogen receptor signaling pathway GO:0030522 intracellular receptor signaling pathway GO:0042445 hormone metabolic process GO:0043401 steroid hormone mediated signaling pathway GO:0048545 response to steroid hormone GO:0050684 regulation of mRNA processing GO:0071383 cellular response to steroid hormone stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:1903311 regulation of mRNA metabolic process |
Molecular Function |
GO:0001047 core promoter binding GO:0003682 chromatin binding |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | SAFB |
Name | scaffold attachment factor B |
Aliases | SAFB1; Hsp27 ERE-TATA binding protein; SAF-B11; HSP27 ERE-TATA-binding protein; HSP27 estrogen response elem ...... |
Chromosomal Location | 19p13.3-p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SAFB and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SAFB |
Name | scaffold attachment factor B |
Aliases | SAFB1; Hsp27 ERE-TATA binding protein; SAF-B11; HSP27 ERE-TATA-binding protein; HSP27 estrogen response elem ...... |
Chromosomal Location | 19p13.3-p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SAFB in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SAFB |
Name | scaffold attachment factor B |
Aliases | SAFB1; Hsp27 ERE-TATA binding protein; SAF-B11; HSP27 ERE-TATA-binding protein; HSP27 estrogen response elem ...... |
Chromosomal Location | 19p13.3-p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SAFB in various data sets.
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Points in the above scatter plot represent the mutation difference of SAFB in various data sets.
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Summary | |
---|---|
Symbol | SAFB |
Name | scaffold attachment factor B |
Aliases | SAFB1; Hsp27 ERE-TATA binding protein; SAF-B11; HSP27 ERE-TATA-binding protein; HSP27 estrogen response elem ...... |
Chromosomal Location | 19p13.3-p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SAFB. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | SAFB |
Name | scaffold attachment factor B |
Aliases | SAFB1; Hsp27 ERE-TATA binding protein; SAF-B11; HSP27 ERE-TATA-binding protein; HSP27 estrogen response elem ...... |
Chromosomal Location | 19p13.3-p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SAFB. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SAFB. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SAFB |
Name | scaffold attachment factor B |
Aliases | SAFB1; Hsp27 ERE-TATA binding protein; SAF-B11; HSP27 ERE-TATA-binding protein; HSP27 estrogen response elem ...... |
Chromosomal Location | 19p13.3-p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SAFB. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | SAFB |
Name | scaffold attachment factor B |
Aliases | SAFB1; Hsp27 ERE-TATA binding protein; SAF-B11; HSP27 ERE-TATA-binding protein; HSP27 estrogen response elem ...... |
Chromosomal Location | 19p13.3-p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SAFB expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | SAFB |
Name | scaffold attachment factor B |
Aliases | SAFB1; Hsp27 ERE-TATA binding protein; SAF-B11; HSP27 ERE-TATA-binding protein; HSP27 estrogen response elem ...... |
Chromosomal Location | 19p13.3-p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SAFB and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SAFB |
Name | scaffold attachment factor B |
Aliases | SAFB1; Hsp27 ERE-TATA binding protein; SAF-B11; HSP27 ERE-TATA-binding protein; HSP27 estrogen response elem ...... |
Chromosomal Location | 19p13.3-p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SAFB collected from DrugBank database. |
There is no record. |