Summary | |
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Symbol | SALL2 |
Name | spalt-like transcription factor 2 |
Aliases | KIAA0360; Hsal2; ZNF795; sal (Drosophila)-like 2; sal-like 2 (Drosophila); COLB; Sal-2; p150(Sal2); zinc fin ...... |
Chromosomal Location | 14q11.1-q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain | - |
Function |
Probable transcription factor that plays a role in eye development before, during, and after optic fissure closure. |
Biological Process |
GO:0001654 eye development GO:0007423 sensory organ development GO:0021915 neural tube development |
Molecular Function | - |
Cellular Component |
GO:0000118 histone deacetylase complex GO:0016581 NuRD complex GO:0017053 transcriptional repressor complex GO:0070603 SWI/SNF superfamily-type complex GO:0090545 CHD-type complex GO:0090568 nuclear transcriptional repressor complex |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | SALL2 |
Name | spalt-like transcription factor 2 |
Aliases | KIAA0360; Hsal2; ZNF795; sal (Drosophila)-like 2; sal-like 2 (Drosophila); COLB; Sal-2; p150(Sal2); zinc fin ...... |
Chromosomal Location | 14q11.1-q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SALL2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between SALL2 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | SALL2 |
Name | spalt-like transcription factor 2 |
Aliases | KIAA0360; Hsal2; ZNF795; sal (Drosophila)-like 2; sal-like 2 (Drosophila); COLB; Sal-2; p150(Sal2); zinc fin ...... |
Chromosomal Location | 14q11.1-q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SALL2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SALL2 |
Name | spalt-like transcription factor 2 |
Aliases | KIAA0360; Hsal2; ZNF795; sal (Drosophila)-like 2; sal-like 2 (Drosophila); COLB; Sal-2; p150(Sal2); zinc fin ...... |
Chromosomal Location | 14q11.1-q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SALL2 in various data sets.
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Points in the above scatter plot represent the mutation difference of SALL2 in various data sets.
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Summary | |
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Symbol | SALL2 |
Name | spalt-like transcription factor 2 |
Aliases | KIAA0360; Hsal2; ZNF795; sal (Drosophila)-like 2; sal-like 2 (Drosophila); COLB; Sal-2; p150(Sal2); zinc fin ...... |
Chromosomal Location | 14q11.1-q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SALL2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | SALL2 |
Name | spalt-like transcription factor 2 |
Aliases | KIAA0360; Hsal2; ZNF795; sal (Drosophila)-like 2; sal-like 2 (Drosophila); COLB; Sal-2; p150(Sal2); zinc fin ...... |
Chromosomal Location | 14q11.1-q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SALL2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SALL2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SALL2 |
Name | spalt-like transcription factor 2 |
Aliases | KIAA0360; Hsal2; ZNF795; sal (Drosophila)-like 2; sal-like 2 (Drosophila); COLB; Sal-2; p150(Sal2); zinc fin ...... |
Chromosomal Location | 14q11.1-q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SALL2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | SALL2 |
Name | spalt-like transcription factor 2 |
Aliases | KIAA0360; Hsal2; ZNF795; sal (Drosophila)-like 2; sal-like 2 (Drosophila); COLB; Sal-2; p150(Sal2); zinc fin ...... |
Chromosomal Location | 14q11.1-q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SALL2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | SALL2 |
Name | spalt-like transcription factor 2 |
Aliases | KIAA0360; Hsal2; ZNF795; sal (Drosophila)-like 2; sal-like 2 (Drosophila); COLB; Sal-2; p150(Sal2); zinc fin ...... |
Chromosomal Location | 14q11.1-q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SALL2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | SALL2 |
Name | spalt-like transcription factor 2 |
Aliases | KIAA0360; Hsal2; ZNF795; sal (Drosophila)-like 2; sal-like 2 (Drosophila); COLB; Sal-2; p150(Sal2); zinc fin ...... |
Chromosomal Location | 14q11.1-q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SALL2 collected from DrugBank database. |
There is no record. |