Summary | |
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Symbol | SAMD4A |
Name | sterile alpha motif domain containing 4A |
Aliases | KIAA1053; DKFZP434H0350; Smaug; SMGA; hSmaug1; smaug homolog (Drosophila); SAMD4; sterile alpha motif domain ...... |
Chromosomal Location | 14q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Cell projection, dendrite Cell junction, synapse, synaptosome Note=Enriched in synaptoneurosomes (By similarity). Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Colocalizes throughout the cytoplasm in granules with polyadenylated RNAs, PABPC1 and STAU1. Also frequently colocalizes in cytoplasmic stress granule-like foci with ELAVL1, TIA1 and TIAL1. |
Domain |
PF00536 SAM domain (Sterile alpha motif) |
Function |
Acts as a translational repressor of SRE-containing messengers. |
Biological Process |
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening GO:0000956 nuclear-transcribed mRNA catabolic process GO:0006401 RNA catabolic process GO:0006402 mRNA catabolic process GO:0006417 regulation of translation GO:0010608 posttranscriptional regulation of gene expression GO:0017148 negative regulation of translation GO:0019439 aromatic compound catabolic process GO:0034248 regulation of cellular amide metabolic process GO:0034249 negative regulation of cellular amide metabolic process GO:0034250 positive regulation of cellular amide metabolic process GO:0034655 nucleobase-containing compound catabolic process GO:0043487 regulation of RNA stability GO:0043488 regulation of mRNA stability GO:0044270 cellular nitrogen compound catabolic process GO:0045727 positive regulation of translation GO:0046700 heterocycle catabolic process GO:1901361 organic cyclic compound catabolic process |
Molecular Function |
GO:0003729 mRNA binding GO:0030371 translation repressor activity GO:0045182 translation regulator activity |
Cellular Component |
GO:0000932 cytoplasmic mRNA processing body GO:0030425 dendrite GO:0035770 ribonucleoprotein granule GO:0036464 cytoplasmic ribonucleoprotein granule |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | SAMD4A |
Name | sterile alpha motif domain containing 4A |
Aliases | KIAA1053; DKFZP434H0350; Smaug; SMGA; hSmaug1; smaug homolog (Drosophila); SAMD4; sterile alpha motif domain ...... |
Chromosomal Location | 14q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SAMD4A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SAMD4A |
Name | sterile alpha motif domain containing 4A |
Aliases | KIAA1053; DKFZP434H0350; Smaug; SMGA; hSmaug1; smaug homolog (Drosophila); SAMD4; sterile alpha motif domain ...... |
Chromosomal Location | 14q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SAMD4A in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SAMD4A |
Name | sterile alpha motif domain containing 4A |
Aliases | KIAA1053; DKFZP434H0350; Smaug; SMGA; hSmaug1; smaug homolog (Drosophila); SAMD4; sterile alpha motif domain ...... |
Chromosomal Location | 14q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SAMD4A in various data sets.
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Points in the above scatter plot represent the mutation difference of SAMD4A in various data sets.
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Summary | |
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Symbol | SAMD4A |
Name | sterile alpha motif domain containing 4A |
Aliases | KIAA1053; DKFZP434H0350; Smaug; SMGA; hSmaug1; smaug homolog (Drosophila); SAMD4; sterile alpha motif domain ...... |
Chromosomal Location | 14q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SAMD4A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | SAMD4A |
Name | sterile alpha motif domain containing 4A |
Aliases | KIAA1053; DKFZP434H0350; Smaug; SMGA; hSmaug1; smaug homolog (Drosophila); SAMD4; sterile alpha motif domain ...... |
Chromosomal Location | 14q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SAMD4A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SAMD4A. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SAMD4A |
Name | sterile alpha motif domain containing 4A |
Aliases | KIAA1053; DKFZP434H0350; Smaug; SMGA; hSmaug1; smaug homolog (Drosophila); SAMD4; sterile alpha motif domain ...... |
Chromosomal Location | 14q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SAMD4A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | SAMD4A |
Name | sterile alpha motif domain containing 4A |
Aliases | KIAA1053; DKFZP434H0350; Smaug; SMGA; hSmaug1; smaug homolog (Drosophila); SAMD4; sterile alpha motif domain ...... |
Chromosomal Location | 14q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SAMD4A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | SAMD4A |
Name | sterile alpha motif domain containing 4A |
Aliases | KIAA1053; DKFZP434H0350; Smaug; SMGA; hSmaug1; smaug homolog (Drosophila); SAMD4; sterile alpha motif domain ...... |
Chromosomal Location | 14q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SAMD4A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | SAMD4A |
Name | sterile alpha motif domain containing 4A |
Aliases | KIAA1053; DKFZP434H0350; Smaug; SMGA; hSmaug1; smaug homolog (Drosophila); SAMD4; sterile alpha motif domain ...... |
Chromosomal Location | 14q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SAMD4A collected from DrugBank database. |
There is no record. |