Browse SATL1

Summary
SymbolSATL1
Namespermidine/spermine N1-acetyl transferase-like 1
Aliases Spermidine/spermine N(1)-acetyltransferase-like protein 1
Chromosomal LocationXq21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location -
Domain PF00583 Acetyltransferase (GNAT) family
Function

-

> Gene Ontology
 
Biological Process GO:0006576 cellular biogenic amine metabolic process
GO:0006595 polyamine metabolic process
GO:0006598 polyamine catabolic process
GO:0008215 spermine metabolic process
GO:0008216 spermidine metabolic process
GO:0009308 amine metabolic process
GO:0009310 amine catabolic process
GO:0009445 putrescine metabolic process
GO:0032917 polyamine acetylation
GO:0032918 spermidine acetylation
GO:0032919 spermine acetylation
GO:0032920 putrescine acetylation
GO:0042402 cellular biogenic amine catabolic process
GO:0044106 cellular amine metabolic process
GO:0046204 nor-spermidine metabolic process
GO:0046208 spermine catabolic process
GO:1901565 organonitrogen compound catabolic process
Molecular Function GO:0004145 diamine N-acetyltransferase activity
GO:0008080 N-acetyltransferase activity
GO:0016407 acetyltransferase activity
GO:0016410 N-acyltransferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
GO:0019808 polyamine binding
GO:0019809 spermidine binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolSATL1
Namespermidine/spermine N1-acetyl transferase-like 1
Aliases Spermidine/spermine N(1)-acetyltransferase-like protein 1
Chromosomal LocationXq21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SATL1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolSATL1
Namespermidine/spermine N1-acetyl transferase-like 1
Aliases Spermidine/spermine N(1)-acetyltransferase-like protein 1
Chromosomal LocationXq21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SATL1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolSATL1
Namespermidine/spermine N1-acetyl transferase-like 1
Aliases Spermidine/spermine N(1)-acetyltransferase-like protein 1
Chromosomal LocationXq21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SATL1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.2020.726
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.1150.933
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.3230.824
729033130MelanomaallAnti-PD-1 (nivolumab) 262301
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 151101
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 111201
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.1420.737
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.160.79
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.8651.78e-05
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of SATL1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.75.5-1.81
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.75.1-1.41
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolSATL1
Namespermidine/spermine N1-acetyl transferase-like 1
Aliases Spermidine/spermine N(1)-acetyltransferase-like protein 1
Chromosomal LocationXq21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SATL1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSATL1
Namespermidine/spermine N1-acetyl transferase-like 1
Aliases Spermidine/spermine N(1)-acetyltransferase-like protein 1
Chromosomal LocationXq21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SATL1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SATL1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSATL1
Namespermidine/spermine N1-acetyl transferase-like 1
Aliases Spermidine/spermine N(1)-acetyltransferase-like protein 1
Chromosomal LocationXq21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SATL1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSATL1
Namespermidine/spermine N1-acetyl transferase-like 1
Aliases Spermidine/spermine N(1)-acetyltransferase-like protein 1
Chromosomal LocationXq21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SATL1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSATL1
Namespermidine/spermine N1-acetyl transferase-like 1
Aliases Spermidine/spermine N(1)-acetyltransferase-like protein 1
Chromosomal LocationXq21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SATL1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSATL1
Namespermidine/spermine N1-acetyl transferase-like 1
Aliases Spermidine/spermine N(1)-acetyltransferase-like protein 1
Chromosomal LocationXq21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SATL1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.