Summary | |
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Symbol | SATL1 |
Name | spermidine/spermine N1-acetyl transferase-like 1 |
Aliases | Spermidine/spermine N(1)-acetyltransferase-like protein 1 |
Chromosomal Location | Xq21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF00583 Acetyltransferase (GNAT) family |
Function |
- |
Biological Process |
GO:0006576 cellular biogenic amine metabolic process GO:0006595 polyamine metabolic process GO:0006598 polyamine catabolic process GO:0008215 spermine metabolic process GO:0008216 spermidine metabolic process GO:0009308 amine metabolic process GO:0009310 amine catabolic process GO:0009445 putrescine metabolic process GO:0032917 polyamine acetylation GO:0032918 spermidine acetylation GO:0032919 spermine acetylation GO:0032920 putrescine acetylation GO:0042402 cellular biogenic amine catabolic process GO:0044106 cellular amine metabolic process GO:0046204 nor-spermidine metabolic process GO:0046208 spermine catabolic process GO:1901565 organonitrogen compound catabolic process |
Molecular Function |
GO:0004145 diamine N-acetyltransferase activity GO:0008080 N-acetyltransferase activity GO:0016407 acetyltransferase activity GO:0016410 N-acyltransferase activity GO:0016746 transferase activity, transferring acyl groups GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GO:0019808 polyamine binding GO:0019809 spermidine binding |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | SATL1 |
Name | spermidine/spermine N1-acetyl transferase-like 1 |
Aliases | Spermidine/spermine N(1)-acetyltransferase-like protein 1 |
Chromosomal Location | Xq21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SATL1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SATL1 |
Name | spermidine/spermine N1-acetyl transferase-like 1 |
Aliases | Spermidine/spermine N(1)-acetyltransferase-like protein 1 |
Chromosomal Location | Xq21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SATL1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SATL1 |
Name | spermidine/spermine N1-acetyl transferase-like 1 |
Aliases | Spermidine/spermine N(1)-acetyltransferase-like protein 1 |
Chromosomal Location | Xq21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SATL1 in various data sets.
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Points in the above scatter plot represent the mutation difference of SATL1 in various data sets.
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Summary | |
---|---|
Symbol | SATL1 |
Name | spermidine/spermine N1-acetyl transferase-like 1 |
Aliases | Spermidine/spermine N(1)-acetyltransferase-like protein 1 |
Chromosomal Location | Xq21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SATL1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | SATL1 |
Name | spermidine/spermine N1-acetyl transferase-like 1 |
Aliases | Spermidine/spermine N(1)-acetyltransferase-like protein 1 |
Chromosomal Location | Xq21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SATL1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SATL1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SATL1 |
Name | spermidine/spermine N1-acetyl transferase-like 1 |
Aliases | Spermidine/spermine N(1)-acetyltransferase-like protein 1 |
Chromosomal Location | Xq21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SATL1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | SATL1 |
Name | spermidine/spermine N1-acetyl transferase-like 1 |
Aliases | Spermidine/spermine N(1)-acetyltransferase-like protein 1 |
Chromosomal Location | Xq21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SATL1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SATL1 |
Name | spermidine/spermine N1-acetyl transferase-like 1 |
Aliases | Spermidine/spermine N(1)-acetyltransferase-like protein 1 |
Chromosomal Location | Xq21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SATL1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SATL1 |
Name | spermidine/spermine N1-acetyl transferase-like 1 |
Aliases | Spermidine/spermine N(1)-acetyltransferase-like protein 1 |
Chromosomal Location | Xq21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SATL1 collected from DrugBank database. |
There is no record. |