Summary | |
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Symbol | SBF1 |
Name | SET binding factor 1 |
Aliases | MTMR5; DENND7A; myotubularin related 5; DENN/MADD domain containing 7A; CMT4B3; SET-binding factor 1; Myotub ...... |
Chromosomal Location | 22q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF02141 DENN (AEX-3) domain PF02893 GRAM domain PF06602 Myotubularin-like phosphatase domain PF00169 PH domain PF12335 Myotubularin protein PF03456 uDENN domain |
Function |
Probable pseudophosphatase. Lacks several amino acids in the catalytic pocket which renders it catalytically inactive as a phosphatase. The pocket is however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases. Inhibits myoblast differentiation in vitro and induces oncogenic transformation in fibroblasts. According to PubMed:20937701, may function as a guanine nucleotide exchange factor (GEF) activating RAB28. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. |
Biological Process |
GO:0006470 protein dephosphorylation GO:0007283 spermatogenesis GO:0016311 dephosphorylation GO:0048232 male gamete generation |
Molecular Function |
GO:0004721 phosphoprotein phosphatase activity GO:0005085 guanyl-nucleotide exchange factor activity GO:0005088 Ras guanyl-nucleotide exchange factor activity GO:0008138 protein tyrosine/serine/threonine phosphatase activity GO:0016791 phosphatase activity GO:0017112 Rab guanyl-nucleotide exchange factor activity GO:0019208 phosphatase regulator activity GO:0042578 phosphoric ester hydrolase activity |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-199991: Membrane Trafficking R-HSA-8876198: RAB GEFs exchange GTP for GDP on RABs R-HSA-5653656: Vesicle-mediated transport |
Summary | |
---|---|
Symbol | SBF1 |
Name | SET binding factor 1 |
Aliases | MTMR5; DENND7A; myotubularin related 5; DENN/MADD domain containing 7A; CMT4B3; SET-binding factor 1; Myotub ...... |
Chromosomal Location | 22q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SBF1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SBF1 |
Name | SET binding factor 1 |
Aliases | MTMR5; DENND7A; myotubularin related 5; DENN/MADD domain containing 7A; CMT4B3; SET-binding factor 1; Myotub ...... |
Chromosomal Location | 22q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SBF1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SBF1 |
Name | SET binding factor 1 |
Aliases | MTMR5; DENND7A; myotubularin related 5; DENN/MADD domain containing 7A; CMT4B3; SET-binding factor 1; Myotub ...... |
Chromosomal Location | 22q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SBF1 in various data sets.
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Points in the above scatter plot represent the mutation difference of SBF1 in various data sets.
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Summary | |
---|---|
Symbol | SBF1 |
Name | SET binding factor 1 |
Aliases | MTMR5; DENND7A; myotubularin related 5; DENN/MADD domain containing 7A; CMT4B3; SET-binding factor 1; Myotub ...... |
Chromosomal Location | 22q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SBF1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | SBF1 |
Name | SET binding factor 1 |
Aliases | MTMR5; DENND7A; myotubularin related 5; DENN/MADD domain containing 7A; CMT4B3; SET-binding factor 1; Myotub ...... |
Chromosomal Location | 22q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SBF1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SBF1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | SBF1 |
Name | SET binding factor 1 |
Aliases | MTMR5; DENND7A; myotubularin related 5; DENN/MADD domain containing 7A; CMT4B3; SET-binding factor 1; Myotub ...... |
Chromosomal Location | 22q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SBF1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | SBF1 |
Name | SET binding factor 1 |
Aliases | MTMR5; DENND7A; myotubularin related 5; DENN/MADD domain containing 7A; CMT4B3; SET-binding factor 1; Myotub ...... |
Chromosomal Location | 22q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SBF1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SBF1 |
Name | SET binding factor 1 |
Aliases | MTMR5; DENND7A; myotubularin related 5; DENN/MADD domain containing 7A; CMT4B3; SET-binding factor 1; Myotub ...... |
Chromosomal Location | 22q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SBF1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SBF1 |
Name | SET binding factor 1 |
Aliases | MTMR5; DENND7A; myotubularin related 5; DENN/MADD domain containing 7A; CMT4B3; SET-binding factor 1; Myotub ...... |
Chromosomal Location | 22q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SBF1 collected from DrugBank database. |
There is no record. |