Browse SBF1

Summary
SymbolSBF1
NameSET binding factor 1
Aliases MTMR5; DENND7A; myotubularin related 5; DENN/MADD domain containing 7A; CMT4B3; SET-binding factor 1; Myotub ......
Chromosomal Location22q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus
Domain PF02141 DENN (AEX-3) domain
PF02893 GRAM domain
PF06602 Myotubularin-like phosphatase domain
PF00169 PH domain
PF12335 Myotubularin protein
PF03456 uDENN domain
Function

Probable pseudophosphatase. Lacks several amino acids in the catalytic pocket which renders it catalytically inactive as a phosphatase. The pocket is however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases. Inhibits myoblast differentiation in vitro and induces oncogenic transformation in fibroblasts. According to PubMed:20937701, may function as a guanine nucleotide exchange factor (GEF) activating RAB28. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.

> Gene Ontology
 
Biological Process GO:0006470 protein dephosphorylation
GO:0007283 spermatogenesis
GO:0016311 dephosphorylation
GO:0048232 male gamete generation
Molecular Function GO:0004721 phosphoprotein phosphatase activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016791 phosphatase activity
GO:0017112 Rab guanyl-nucleotide exchange factor activity
GO:0019208 phosphatase regulator activity
GO:0042578 phosphoric ester hydrolase activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-199991: Membrane Trafficking
R-HSA-8876198: RAB GEFs exchange GTP for GDP on RABs
R-HSA-5653656: Vesicle-mediated transport
Summary
SymbolSBF1
NameSET binding factor 1
Aliases MTMR5; DENND7A; myotubularin related 5; DENN/MADD domain containing 7A; CMT4B3; SET-binding factor 1; Myotub ......
Chromosomal Location22q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SBF1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolSBF1
NameSET binding factor 1
Aliases MTMR5; DENND7A; myotubularin related 5; DENN/MADD domain containing 7A; CMT4B3; SET-binding factor 1; Myotub ......
Chromosomal Location22q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SBF1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen Total # shRNA with >= 4-fold: 1 Resistant to T-cell proliferation
24476824shRNAmelanomaB16Secondary screen Total # shRNA with >= 4-fold: 4 Resistant to T-cell proliferation
Summary
SymbolSBF1
NameSET binding factor 1
Aliases MTMR5; DENND7A; myotubularin related 5; DENN/MADD domain containing 7A; CMT4B3; SET-binding factor 1; Myotub ......
Chromosomal Location22q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SBF1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0440.886
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.1030.959
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.1540.92
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0450.894
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.0480.986
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.0430.99
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.3440.388
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.1930.909
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.5280.778
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.0290.983
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.2680.889
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0490.496
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of SBF1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141705.9-5.91
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 41407.1-7.11
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.74.1-0.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.75.1-1.41
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 382703.7-3.70.415
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161407.1-7.10.467
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11139.109.10.458
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 512200200.294
Summary
SymbolSBF1
NameSET binding factor 1
Aliases MTMR5; DENND7A; myotubularin related 5; DENN/MADD domain containing 7A; CMT4B3; SET-binding factor 1; Myotub ......
Chromosomal Location22q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SBF1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSBF1
NameSET binding factor 1
Aliases MTMR5; DENND7A; myotubularin related 5; DENN/MADD domain containing 7A; CMT4B3; SET-binding factor 1; Myotub ......
Chromosomal Location22q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SBF1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SBF1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSBF1
NameSET binding factor 1
Aliases MTMR5; DENND7A; myotubularin related 5; DENN/MADD domain containing 7A; CMT4B3; SET-binding factor 1; Myotub ......
Chromosomal Location22q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SBF1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSBF1
NameSET binding factor 1
Aliases MTMR5; DENND7A; myotubularin related 5; DENN/MADD domain containing 7A; CMT4B3; SET-binding factor 1; Myotub ......
Chromosomal Location22q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SBF1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSBF1
NameSET binding factor 1
Aliases MTMR5; DENND7A; myotubularin related 5; DENN/MADD domain containing 7A; CMT4B3; SET-binding factor 1; Myotub ......
Chromosomal Location22q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SBF1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSBF1
NameSET binding factor 1
Aliases MTMR5; DENND7A; myotubularin related 5; DENN/MADD domain containing 7A; CMT4B3; SET-binding factor 1; Myotub ......
Chromosomal Location22q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SBF1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.