Browse SCD

Summary
SymbolSCD
Namestearoyl-CoA desaturase (delta-9-desaturase)
Aliases FADS5; acyl-CoA desaturase; fatty acid desaturase; SCDOS; stearoyl-CoA desaturase opposite strand; MSTP0081; ......
Chromosomal Location10q23-q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Endoplasmic reticulum membrane Multi-pass membrane protein
Domain -
Function

Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:15907797, PubMed:18765284). Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15907797, PubMed:18765284). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069). Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity).

> Gene Ontology
 
Biological Process GO:0001676 long-chain fatty acid metabolic process
GO:0006631 fatty acid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0006636 unsaturated fatty acid biosynthetic process
GO:0006637 acyl-CoA metabolic process
GO:0006732 coenzyme metabolic process
GO:0006790 sulfur compound metabolic process
GO:0009108 coenzyme biosynthetic process
GO:0016053 organic acid biosynthetic process
GO:0033559 unsaturated fatty acid metabolic process
GO:0035336 long-chain fatty-acyl-CoA metabolic process
GO:0035337 fatty-acyl-CoA metabolic process
GO:0035338 long-chain fatty-acyl-CoA biosynthetic process
GO:0035383 thioester metabolic process
GO:0035384 thioester biosynthetic process
GO:0042759 long-chain fatty acid biosynthetic process
GO:0044272 sulfur compound biosynthetic process
GO:0044283 small molecule biosynthetic process
GO:0046394 carboxylic acid biosynthetic process
GO:0046949 fatty-acyl-CoA biosynthetic process
GO:0051186 cofactor metabolic process
GO:0051188 cofactor biosynthetic process
GO:0071616 acyl-CoA biosynthetic process
GO:0072330 monocarboxylic acid biosynthetic process
GO:1903964 monounsaturated fatty acid metabolic process
GO:1903966 monounsaturated fatty acid biosynthetic process
Molecular Function GO:0004768 stearoyl-CoA 9-desaturase activity
GO:0005506 iron ion binding
GO:0016215 acyl-CoA desaturase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa03320 PPAR signaling pathway
hsa04152 AMPK signaling pathway
hsa01040 Biosynthesis of unsaturated fatty acids
hsa01212 Fatty acid metabolism
Reactome R-HSA-2426168: Activation of gene expression by SREBF (SREBP)
R-HSA-75105: Fatty Acyl-CoA Biosynthesis
R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism
R-HSA-1430728: Metabolism
R-HSA-556833: Metabolism of lipids and lipoproteins
R-HSA-1655829: Regulation of cholesterol biosynthesis by SREBP (SREBF)
R-HSA-75109: Triglyceride Biosynthesis
Summary
SymbolSCD
Namestearoyl-CoA desaturase (delta-9-desaturase)
Aliases FADS5; acyl-CoA desaturase; fatty acid desaturase; SCDOS; stearoyl-CoA desaturase opposite strand; MSTP0081; ......
Chromosomal Location10q23-q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SCD and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolSCD
Namestearoyl-CoA desaturase (delta-9-desaturase)
Aliases FADS5; acyl-CoA desaturase; fatty acid desaturase; SCDOS; stearoyl-CoA desaturase opposite strand; MSTP0081; ......
Chromosomal Location10q23-q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SCD in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.54 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolSCD
Namestearoyl-CoA desaturase (delta-9-desaturase)
Aliases FADS5; acyl-CoA desaturase; fatty acid desaturase; SCDOS; stearoyl-CoA desaturase opposite strand; MSTP0081; ......
Chromosomal Location10q23-q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SCD in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.2680.509
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.8250.783
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.1330.95
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.6480.347
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.4460.822
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 472.0450.467
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1410.785
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.5120.833
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.3580.899
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.1610.555
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 282.1880.465
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.130.476
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of SCD in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolSCD
Namestearoyl-CoA desaturase (delta-9-desaturase)
Aliases FADS5; acyl-CoA desaturase; fatty acid desaturase; SCDOS; stearoyl-CoA desaturase opposite strand; MSTP0081; ......
Chromosomal Location10q23-q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SCD. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSCD
Namestearoyl-CoA desaturase (delta-9-desaturase)
Aliases FADS5; acyl-CoA desaturase; fatty acid desaturase; SCDOS; stearoyl-CoA desaturase opposite strand; MSTP0081; ......
Chromosomal Location10q23-q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SCD. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SCD.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSCD
Namestearoyl-CoA desaturase (delta-9-desaturase)
Aliases FADS5; acyl-CoA desaturase; fatty acid desaturase; SCDOS; stearoyl-CoA desaturase opposite strand; MSTP0081; ......
Chromosomal Location10q23-q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SCD. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSCD
Namestearoyl-CoA desaturase (delta-9-desaturase)
Aliases FADS5; acyl-CoA desaturase; fatty acid desaturase; SCDOS; stearoyl-CoA desaturase opposite strand; MSTP0081; ......
Chromosomal Location10q23-q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SCD expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSCD
Namestearoyl-CoA desaturase (delta-9-desaturase)
Aliases FADS5; acyl-CoA desaturase; fatty acid desaturase; SCDOS; stearoyl-CoA desaturase opposite strand; MSTP0081; ......
Chromosomal Location10q23-q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SCD and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSCD
Namestearoyl-CoA desaturase (delta-9-desaturase)
Aliases FADS5; acyl-CoA desaturase; fatty acid desaturase; SCDOS; stearoyl-CoA desaturase opposite strand; MSTP0081; ......
Chromosomal Location10q23-q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SCD collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.