Summary | |
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Symbol | SCD |
Name | stearoyl-CoA desaturase (delta-9-desaturase) |
Aliases | FADS5; acyl-CoA desaturase; fatty acid desaturase; SCDOS; stearoyl-CoA desaturase opposite strand; MSTP0081; ...... |
Chromosomal Location | 10q23-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Endoplasmic reticulum membrane Multi-pass membrane protein |
Domain | - |
Function |
Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:15907797, PubMed:18765284). Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15907797, PubMed:18765284). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069). Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity). |
Biological Process |
GO:0001676 long-chain fatty acid metabolic process GO:0006631 fatty acid metabolic process GO:0006633 fatty acid biosynthetic process GO:0006636 unsaturated fatty acid biosynthetic process GO:0006637 acyl-CoA metabolic process GO:0006732 coenzyme metabolic process GO:0006790 sulfur compound metabolic process GO:0009108 coenzyme biosynthetic process GO:0016053 organic acid biosynthetic process GO:0033559 unsaturated fatty acid metabolic process GO:0035336 long-chain fatty-acyl-CoA metabolic process GO:0035337 fatty-acyl-CoA metabolic process GO:0035338 long-chain fatty-acyl-CoA biosynthetic process GO:0035383 thioester metabolic process GO:0035384 thioester biosynthetic process GO:0042759 long-chain fatty acid biosynthetic process GO:0044272 sulfur compound biosynthetic process GO:0044283 small molecule biosynthetic process GO:0046394 carboxylic acid biosynthetic process GO:0046949 fatty-acyl-CoA biosynthetic process GO:0051186 cofactor metabolic process GO:0051188 cofactor biosynthetic process GO:0071616 acyl-CoA biosynthetic process GO:0072330 monocarboxylic acid biosynthetic process GO:1903964 monounsaturated fatty acid metabolic process GO:1903966 monounsaturated fatty acid biosynthetic process |
Molecular Function |
GO:0004768 stearoyl-CoA 9-desaturase activity GO:0005506 iron ion binding GO:0016215 acyl-CoA desaturase activity GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water |
Cellular Component | - |
KEGG |
hsa03320 PPAR signaling pathway hsa04152 AMPK signaling pathway hsa01040 Biosynthesis of unsaturated fatty acids hsa01212 Fatty acid metabolism |
Reactome |
R-HSA-2426168: Activation of gene expression by SREBF (SREBP) R-HSA-75105: Fatty Acyl-CoA Biosynthesis R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-1655829: Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-75109: Triglyceride Biosynthesis |
Summary | |
---|---|
Symbol | SCD |
Name | stearoyl-CoA desaturase (delta-9-desaturase) |
Aliases | FADS5; acyl-CoA desaturase; fatty acid desaturase; SCDOS; stearoyl-CoA desaturase opposite strand; MSTP0081; ...... |
Chromosomal Location | 10q23-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SCD and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SCD |
Name | stearoyl-CoA desaturase (delta-9-desaturase) |
Aliases | FADS5; acyl-CoA desaturase; fatty acid desaturase; SCDOS; stearoyl-CoA desaturase opposite strand; MSTP0081; ...... |
Chromosomal Location | 10q23-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SCD in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SCD |
Name | stearoyl-CoA desaturase (delta-9-desaturase) |
Aliases | FADS5; acyl-CoA desaturase; fatty acid desaturase; SCDOS; stearoyl-CoA desaturase opposite strand; MSTP0081; ...... |
Chromosomal Location | 10q23-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SCD in various data sets.
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Points in the above scatter plot represent the mutation difference of SCD in various data sets.
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Summary | |
---|---|
Symbol | SCD |
Name | stearoyl-CoA desaturase (delta-9-desaturase) |
Aliases | FADS5; acyl-CoA desaturase; fatty acid desaturase; SCDOS; stearoyl-CoA desaturase opposite strand; MSTP0081; ...... |
Chromosomal Location | 10q23-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SCD. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | SCD |
Name | stearoyl-CoA desaturase (delta-9-desaturase) |
Aliases | FADS5; acyl-CoA desaturase; fatty acid desaturase; SCDOS; stearoyl-CoA desaturase opposite strand; MSTP0081; ...... |
Chromosomal Location | 10q23-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SCD. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SCD. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SCD |
Name | stearoyl-CoA desaturase (delta-9-desaturase) |
Aliases | FADS5; acyl-CoA desaturase; fatty acid desaturase; SCDOS; stearoyl-CoA desaturase opposite strand; MSTP0081; ...... |
Chromosomal Location | 10q23-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SCD. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | SCD |
Name | stearoyl-CoA desaturase (delta-9-desaturase) |
Aliases | FADS5; acyl-CoA desaturase; fatty acid desaturase; SCDOS; stearoyl-CoA desaturase opposite strand; MSTP0081; ...... |
Chromosomal Location | 10q23-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SCD expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SCD |
Name | stearoyl-CoA desaturase (delta-9-desaturase) |
Aliases | FADS5; acyl-CoA desaturase; fatty acid desaturase; SCDOS; stearoyl-CoA desaturase opposite strand; MSTP0081; ...... |
Chromosomal Location | 10q23-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SCD and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SCD |
Name | stearoyl-CoA desaturase (delta-9-desaturase) |
Aliases | FADS5; acyl-CoA desaturase; fatty acid desaturase; SCDOS; stearoyl-CoA desaturase opposite strand; MSTP0081; ...... |
Chromosomal Location | 10q23-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SCD collected from DrugBank database. |
There is no record. |