Summary | |
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Symbol | SCGB1A1 |
Name | secretoglobin, family 1A, member 1 (uteroglobin) |
Aliases | CC10; CCSP; CC16; Uteroglobin (Clara-cell specific 10-kD protein); UGB; uteroglobin; CCPBP; UP-1; UP1; blast ...... |
Chromosomal Location | 11q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted. |
Domain |
PF01099 Uteroglobin family |
Function |
Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2. |
Biological Process |
GO:0000302 response to reactive oxygen species GO:0001101 response to acid chemical GO:0001818 negative regulation of cytokine production GO:0002237 response to molecule of bacterial origin GO:0002683 negative regulation of immune system process GO:0002694 regulation of leukocyte activation GO:0002695 negative regulation of leukocyte activation GO:0006979 response to oxidative stress GO:0007159 leukocyte cell-cell adhesion GO:0007162 negative regulation of cell adhesion GO:0007565 female pregnancy GO:0007566 embryo implantation GO:0009410 response to xenobiotic stimulus GO:0010035 response to inorganic substance GO:0010193 response to ozone GO:0010608 posttranscriptional regulation of gene expression GO:0022407 regulation of cell-cell adhesion GO:0022408 negative regulation of cell-cell adhesion GO:0031960 response to corticosteroid GO:0032496 response to lipopolysaccharide GO:0032609 interferon-gamma production GO:0032616 interleukin-13 production GO:0032633 interleukin-4 production GO:0032634 interleukin-5 production GO:0032649 regulation of interferon-gamma production GO:0032656 regulation of interleukin-13 production GO:0032673 regulation of interleukin-4 production GO:0032674 regulation of interleukin-5 production GO:0032689 negative regulation of interferon-gamma production GO:0032696 negative regulation of interleukin-13 production GO:0032713 negative regulation of interleukin-4 production GO:0032714 negative regulation of interleukin-5 production GO:0032943 mononuclear cell proliferation GO:0032944 regulation of mononuclear cell proliferation GO:0032945 negative regulation of mononuclear cell proliferation GO:0034021 response to silicon dioxide GO:0042098 T cell proliferation GO:0042110 T cell activation GO:0042129 regulation of T cell proliferation GO:0042130 negative regulation of T cell proliferation GO:0042493 response to drug GO:0043487 regulation of RNA stability GO:0043488 regulation of mRNA stability GO:0044706 multi-multicellular organism process GO:0046651 lymphocyte proliferation GO:0048545 response to steroid hormone GO:0050670 regulation of lymphocyte proliferation GO:0050672 negative regulation of lymphocyte proliferation GO:0050727 regulation of inflammatory response GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0050866 negative regulation of cell activation GO:0050868 negative regulation of T cell activation GO:0051249 regulation of lymphocyte activation GO:0051250 negative regulation of lymphocyte activation GO:0051384 response to glucocorticoid GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070661 leukocyte proliferation GO:0070663 regulation of leukocyte proliferation GO:0070664 negative regulation of leukocyte proliferation GO:0071593 lymphocyte aggregation GO:0071774 response to fibroblast growth factor GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903038 negative regulation of leukocyte cell-cell adhesion |
Molecular Function |
GO:0004857 enzyme inhibitor activity GO:0004859 phospholipase inhibitor activity GO:0019834 phospholipase A2 inhibitor activity GO:0055102 lipase inhibitor activity GO:0097160 polychlorinated biphenyl binding |
Cellular Component |
GO:0005635 nuclear envelope GO:0005791 rough endoplasmic reticulum GO:0030141 secretory granule GO:0099503 secretory vesicle |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | SCGB1A1 |
Name | secretoglobin, family 1A, member 1 (uteroglobin) |
Aliases | CC10; CCSP; CC16; Uteroglobin (Clara-cell specific 10-kD protein); UGB; uteroglobin; CCPBP; UP-1; UP1; blast ...... |
Chromosomal Location | 11q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SCGB1A1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | SCGB1A1 |
Name | secretoglobin, family 1A, member 1 (uteroglobin) |
Aliases | CC10; CCSP; CC16; Uteroglobin (Clara-cell specific 10-kD protein); UGB; uteroglobin; CCPBP; UP-1; UP1; blast ...... |
Chromosomal Location | 11q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SCGB1A1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SCGB1A1 |
Name | secretoglobin, family 1A, member 1 (uteroglobin) |
Aliases | CC10; CCSP; CC16; Uteroglobin (Clara-cell specific 10-kD protein); UGB; uteroglobin; CCPBP; UP-1; UP1; blast ...... |
Chromosomal Location | 11q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SCGB1A1 in various data sets.
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Points in the above scatter plot represent the mutation difference of SCGB1A1 in various data sets.
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Summary | |
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Symbol | SCGB1A1 |
Name | secretoglobin, family 1A, member 1 (uteroglobin) |
Aliases | CC10; CCSP; CC16; Uteroglobin (Clara-cell specific 10-kD protein); UGB; uteroglobin; CCPBP; UP-1; UP1; blast ...... |
Chromosomal Location | 11q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SCGB1A1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | SCGB1A1 |
Name | secretoglobin, family 1A, member 1 (uteroglobin) |
Aliases | CC10; CCSP; CC16; Uteroglobin (Clara-cell specific 10-kD protein); UGB; uteroglobin; CCPBP; UP-1; UP1; blast ...... |
Chromosomal Location | 11q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SCGB1A1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SCGB1A1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SCGB1A1 |
Name | secretoglobin, family 1A, member 1 (uteroglobin) |
Aliases | CC10; CCSP; CC16; Uteroglobin (Clara-cell specific 10-kD protein); UGB; uteroglobin; CCPBP; UP-1; UP1; blast ...... |
Chromosomal Location | 11q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SCGB1A1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | SCGB1A1 |
Name | secretoglobin, family 1A, member 1 (uteroglobin) |
Aliases | CC10; CCSP; CC16; Uteroglobin (Clara-cell specific 10-kD protein); UGB; uteroglobin; CCPBP; UP-1; UP1; blast ...... |
Chromosomal Location | 11q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SCGB1A1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | SCGB1A1 |
Name | secretoglobin, family 1A, member 1 (uteroglobin) |
Aliases | CC10; CCSP; CC16; Uteroglobin (Clara-cell specific 10-kD protein); UGB; uteroglobin; CCPBP; UP-1; UP1; blast ...... |
Chromosomal Location | 11q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SCGB1A1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | SCGB1A1 |
Name | secretoglobin, family 1A, member 1 (uteroglobin) |
Aliases | CC10; CCSP; CC16; Uteroglobin (Clara-cell specific 10-kD protein); UGB; uteroglobin; CCPBP; UP-1; UP1; blast ...... |
Chromosomal Location | 11q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SCGB1A1 collected from DrugBank database. |
Details on drugs targeting SCGB1A1.
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