Summary | |
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Symbol | SCGB3A1 |
Name | secretoglobin, family 3A, member 1 |
Aliases | UGRP2; HIN-1; LU105; PnSP-2; cytokine high in normal-1; pneumo secretory protein 2; cytokine HIN-1; high in ...... |
Chromosomal Location | 5q35.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted |
Domain | - |
Function |
Secreted cytokine-like protein. Inhibits cell growth in vitro. |
Biological Process |
GO:0000768 syncytium formation by plasma membrane fusion GO:0001558 regulation of cell growth GO:0006949 syncytium formation GO:0007520 myoblast fusion GO:0010830 regulation of myotube differentiation GO:0010831 positive regulation of myotube differentiation GO:0014902 myotube differentiation GO:0016049 cell growth GO:0030308 negative regulation of cell growth GO:0042692 muscle cell differentiation GO:0045926 negative regulation of growth GO:0051146 striated muscle cell differentiation GO:0051147 regulation of muscle cell differentiation GO:0051149 positive regulation of muscle cell differentiation GO:0051153 regulation of striated muscle cell differentiation GO:0051155 positive regulation of striated muscle cell differentiation GO:0060142 regulation of syncytium formation by plasma membrane fusion GO:0060143 positive regulation of syncytium formation by plasma membrane fusion GO:1901739 regulation of myoblast fusion GO:1901741 positive regulation of myoblast fusion |
Molecular Function |
GO:0005125 cytokine activity |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | SCGB3A1 |
Name | secretoglobin, family 3A, member 1 |
Aliases | UGRP2; HIN-1; LU105; PnSP-2; cytokine high in normal-1; pneumo secretory protein 2; cytokine HIN-1; high in ...... |
Chromosomal Location | 5q35.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SCGB3A1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | SCGB3A1 |
Name | secretoglobin, family 3A, member 1 |
Aliases | UGRP2; HIN-1; LU105; PnSP-2; cytokine high in normal-1; pneumo secretory protein 2; cytokine HIN-1; high in ...... |
Chromosomal Location | 5q35.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SCGB3A1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SCGB3A1 |
Name | secretoglobin, family 3A, member 1 |
Aliases | UGRP2; HIN-1; LU105; PnSP-2; cytokine high in normal-1; pneumo secretory protein 2; cytokine HIN-1; high in ...... |
Chromosomal Location | 5q35.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SCGB3A1 in various data sets.
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Points in the above scatter plot represent the mutation difference of SCGB3A1 in various data sets.
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Summary | |
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Symbol | SCGB3A1 |
Name | secretoglobin, family 3A, member 1 |
Aliases | UGRP2; HIN-1; LU105; PnSP-2; cytokine high in normal-1; pneumo secretory protein 2; cytokine HIN-1; high in ...... |
Chromosomal Location | 5q35.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SCGB3A1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | SCGB3A1 |
Name | secretoglobin, family 3A, member 1 |
Aliases | UGRP2; HIN-1; LU105; PnSP-2; cytokine high in normal-1; pneumo secretory protein 2; cytokine HIN-1; high in ...... |
Chromosomal Location | 5q35.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SCGB3A1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SCGB3A1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SCGB3A1 |
Name | secretoglobin, family 3A, member 1 |
Aliases | UGRP2; HIN-1; LU105; PnSP-2; cytokine high in normal-1; pneumo secretory protein 2; cytokine HIN-1; high in ...... |
Chromosomal Location | 5q35.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SCGB3A1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | SCGB3A1 |
Name | secretoglobin, family 3A, member 1 |
Aliases | UGRP2; HIN-1; LU105; PnSP-2; cytokine high in normal-1; pneumo secretory protein 2; cytokine HIN-1; high in ...... |
Chromosomal Location | 5q35.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SCGB3A1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | SCGB3A1 |
Name | secretoglobin, family 3A, member 1 |
Aliases | UGRP2; HIN-1; LU105; PnSP-2; cytokine high in normal-1; pneumo secretory protein 2; cytokine HIN-1; high in ...... |
Chromosomal Location | 5q35.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SCGB3A1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | SCGB3A1 |
Name | secretoglobin, family 3A, member 1 |
Aliases | UGRP2; HIN-1; LU105; PnSP-2; cytokine high in normal-1; pneumo secretory protein 2; cytokine HIN-1; high in ...... |
Chromosomal Location | 5q35.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SCGB3A1 collected from DrugBank database. |
There is no record. |