Summary | |
---|---|
Symbol | SCMH1 |
Name | sex comb on midleg homolog 1 (Drosophila) |
Aliases | Scml3; Sex comb on midleg homolog 1; Polycomb protein SCMH1 |
Chromosomal Location | 1p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF02820 mbt repeat PF17208 RNA binding Region PF00536 SAM domain (Sterile alpha motif) PF12140 SLED domain |
Function |
Associates with Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes. |
Biological Process |
GO:0003002 regionalization GO:0006338 chromatin remodeling GO:0007283 spermatogenesis GO:0007389 pattern specification process GO:0009952 anterior/posterior pattern specification GO:0016458 gene silencing GO:0016925 protein sumoylation GO:0018205 peptidyl-lysine modification GO:0048232 male gamete generation |
Molecular Function | - |
Cellular Component |
GO:0010369 chromocenter GO:0098687 chromosomal region |
KEGG | - |
Reactome |
R-HSA-2559583: Cellular Senescence R-HSA-2262752: Cellular responses to stress R-HSA-392499: Metabolism of proteins R-HSA-2559580: Oxidative Stress Induced Senescence R-HSA-597592: Post-translational protein modification R-HSA-3108232: SUMO E3 ligases SUMOylate target proteins R-HSA-2990846: SUMOylation R-HSA-3108214: SUMOylation of DNA damage response and repair proteins R-HSA-4570464: SUMOylation of RNA binding proteins |
Summary | |
---|---|
Symbol | SCMH1 |
Name | sex comb on midleg homolog 1 (Drosophila) |
Aliases | Scml3; Sex comb on midleg homolog 1; Polycomb protein SCMH1 |
Chromosomal Location | 1p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SCMH1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SCMH1 |
Name | sex comb on midleg homolog 1 (Drosophila) |
Aliases | Scml3; Sex comb on midleg homolog 1; Polycomb protein SCMH1 |
Chromosomal Location | 1p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of SCMH1 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | SCMH1 |
Name | sex comb on midleg homolog 1 (Drosophila) |
Aliases | Scml3; Sex comb on midleg homolog 1; Polycomb protein SCMH1 |
Chromosomal Location | 1p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SCMH1 in various data sets.
|
Points in the above scatter plot represent the mutation difference of SCMH1 in various data sets.
|
Summary | |
---|---|
Symbol | SCMH1 |
Name | sex comb on midleg homolog 1 (Drosophila) |
Aliases | Scml3; Sex comb on midleg homolog 1; Polycomb protein SCMH1 |
Chromosomal Location | 1p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SCMH1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | SCMH1 |
Name | sex comb on midleg homolog 1 (Drosophila) |
Aliases | Scml3; Sex comb on midleg homolog 1; Polycomb protein SCMH1 |
Chromosomal Location | 1p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SCMH1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SCMH1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | SCMH1 |
Name | sex comb on midleg homolog 1 (Drosophila) |
Aliases | Scml3; Sex comb on midleg homolog 1; Polycomb protein SCMH1 |
Chromosomal Location | 1p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SCMH1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | SCMH1 |
Name | sex comb on midleg homolog 1 (Drosophila) |
Aliases | Scml3; Sex comb on midleg homolog 1; Polycomb protein SCMH1 |
Chromosomal Location | 1p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SCMH1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SCMH1 |
Name | sex comb on midleg homolog 1 (Drosophila) |
Aliases | Scml3; Sex comb on midleg homolog 1; Polycomb protein SCMH1 |
Chromosomal Location | 1p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SCMH1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SCMH1 |
Name | sex comb on midleg homolog 1 (Drosophila) |
Aliases | Scml3; Sex comb on midleg homolog 1; Polycomb protein SCMH1 |
Chromosomal Location | 1p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SCMH1 collected from DrugBank database. |
Details on drugs targeting SCMH1.
|