Browse SCMH1

Summary
SymbolSCMH1
Namesex comb on midleg homolog 1 (Drosophila)
Aliases Scml3; Sex comb on midleg homolog 1; Polycomb protein SCMH1
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus
Domain PF02820 mbt repeat
PF17208 RNA binding Region
PF00536 SAM domain (Sterile alpha motif)
PF12140 SLED domain
Function

Associates with Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes.

> Gene Ontology
 
Biological Process GO:0003002 regionalization
GO:0006338 chromatin remodeling
GO:0007283 spermatogenesis
GO:0007389 pattern specification process
GO:0009952 anterior/posterior pattern specification
GO:0016458 gene silencing
GO:0016925 protein sumoylation
GO:0018205 peptidyl-lysine modification
GO:0048232 male gamete generation
Molecular Function -
Cellular Component GO:0010369 chromocenter
GO:0098687 chromosomal region
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-2559583: Cellular Senescence
R-HSA-2262752: Cellular responses to stress
R-HSA-392499: Metabolism of proteins
R-HSA-2559580: Oxidative Stress Induced Senescence
R-HSA-597592: Post-translational protein modification
R-HSA-3108232: SUMO E3 ligases SUMOylate target proteins
R-HSA-2990846: SUMOylation
R-HSA-3108214: SUMOylation of DNA damage response and repair proteins
R-HSA-4570464: SUMOylation of RNA binding proteins
Summary
SymbolSCMH1
Namesex comb on midleg homolog 1 (Drosophila)
Aliases Scml3; Sex comb on midleg homolog 1; Polycomb protein SCMH1
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SCMH1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolSCMH1
Namesex comb on midleg homolog 1 (Drosophila)
Aliases Scml3; Sex comb on midleg homolog 1; Polycomb protein SCMH1
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SCMH1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.79 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolSCMH1
Namesex comb on midleg homolog 1 (Drosophila)
Aliases Scml3; Sex comb on midleg homolog 1; Polycomb protein SCMH1
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SCMH1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1950.381
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.1910.906
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.4770.689
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.2680.479
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.1820.933
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.3850.896
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0960.756
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.2480.856
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.0390.98
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.4460.737
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.9260.631
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0860.233
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of SCMH1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.72.711
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.73.40.31
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211705.9-5.90.447
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131109.1-9.10.458
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolSCMH1
Namesex comb on midleg homolog 1 (Drosophila)
Aliases Scml3; Sex comb on midleg homolog 1; Polycomb protein SCMH1
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SCMH1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSCMH1
Namesex comb on midleg homolog 1 (Drosophila)
Aliases Scml3; Sex comb on midleg homolog 1; Polycomb protein SCMH1
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SCMH1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SCMH1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSCMH1
Namesex comb on midleg homolog 1 (Drosophila)
Aliases Scml3; Sex comb on midleg homolog 1; Polycomb protein SCMH1
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SCMH1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSCMH1
Namesex comb on midleg homolog 1 (Drosophila)
Aliases Scml3; Sex comb on midleg homolog 1; Polycomb protein SCMH1
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SCMH1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSCMH1
Namesex comb on midleg homolog 1 (Drosophila)
Aliases Scml3; Sex comb on midleg homolog 1; Polycomb protein SCMH1
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SCMH1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSCMH1
Namesex comb on midleg homolog 1 (Drosophila)
Aliases Scml3; Sex comb on midleg homolog 1; Polycomb protein SCMH1
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SCMH1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting SCMH1.
ID Name Drug Type Targets #Targets
DB03345Beta-MercaptoethanolSmall MoleculeGLO1, LGALS1, PNPO, SCMH1, SERPINA15