Summary | |
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Symbol | SCN2B |
Name | sodium channel, voltage gated, type II beta subunit |
Aliases | sodium channel, voltage-gated, type II, beta polypeptide; sodium channel, voltage-gated, type II, beta; sodi ...... |
Chromosomal Location | 11q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Domain |
PF07686 Immunoglobulin V-set domain |
Function |
Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity). |
Biological Process |
GO:0001508 action potential GO:0002027 regulation of heart rate GO:0002028 regulation of sodium ion transport GO:0003012 muscle system process GO:0003013 circulatory system process GO:0003015 heart process GO:0003254 regulation of membrane depolarization GO:0006814 sodium ion transport GO:0006936 muscle contraction GO:0006941 striated muscle contraction GO:0008015 blood circulation GO:0008016 regulation of heart contraction GO:0009636 response to toxic substance GO:0010959 regulation of metal ion transport GO:0015672 monovalent inorganic cation transport GO:0017085 response to insecticide GO:0022898 regulation of transmembrane transporter activity GO:0030048 actin filament-based movement GO:0032409 regulation of transporter activity GO:0032412 regulation of ion transmembrane transporter activity GO:0032844 regulation of homeostatic process GO:0034762 regulation of transmembrane transport GO:0034765 regulation of ion transmembrane transport GO:0035637 multicellular organismal signaling GO:0035725 sodium ion transmembrane transport GO:0042391 regulation of membrane potential GO:0044057 regulation of system process GO:0046684 response to pyrethroid GO:0051899 membrane depolarization GO:0060047 heart contraction GO:0060048 cardiac muscle contraction GO:0060078 regulation of postsynaptic membrane potential GO:0060371 regulation of atrial cardiac muscle cell membrane depolarization GO:0061337 cardiac conduction GO:0070252 actin-mediated cell contraction GO:0086001 cardiac muscle cell action potential GO:0086002 cardiac muscle cell action potential involved in contraction GO:0086003 cardiac muscle cell contraction GO:0086010 membrane depolarization during action potential GO:0086012 membrane depolarization during cardiac muscle cell action potential GO:0086091 regulation of heart rate by cardiac conduction GO:1902305 regulation of sodium ion transmembrane transport GO:1903522 regulation of blood circulation GO:1904062 regulation of cation transmembrane transport GO:2000021 regulation of ion homeostasis GO:2000649 regulation of sodium ion transmembrane transporter activity |
Molecular Function |
GO:0005216 ion channel activity GO:0005244 voltage-gated ion channel activity GO:0005248 voltage-gated sodium channel activity GO:0005261 cation channel activity GO:0005272 sodium channel activity GO:0015077 monovalent inorganic cation transmembrane transporter activity GO:0015081 sodium ion transmembrane transporter activity GO:0015267 channel activity GO:0016247 channel regulator activity GO:0017080 sodium channel regulator activity GO:0022803 passive transmembrane transporter activity GO:0022832 voltage-gated channel activity GO:0022836 gated channel activity GO:0022838 substrate-specific channel activity GO:0046873 metal ion transmembrane transporter activity GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential GO:1905030 voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential |
Cellular Component |
GO:0001518 voltage-gated sodium channel complex GO:0034702 ion channel complex GO:0034703 cation channel complex GO:0034706 sodium channel complex GO:1902495 transmembrane transporter complex GO:1990351 transporter complex |
KEGG | - |
Reactome |
R-HSA-422475: Axon guidance R-HSA-5576891: Cardiac conduction R-HSA-1266738: Developmental Biology R-HSA-445095: Interaction between L1 and Ankyrins R-HSA-373760: L1CAM interactions R-HSA-397014: Muscle contraction R-HSA-5576892: Phase 0 - rapid depolarisation |
Summary | |
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Symbol | SCN2B |
Name | sodium channel, voltage gated, type II beta subunit |
Aliases | sodium channel, voltage-gated, type II, beta polypeptide; sodium channel, voltage-gated, type II, beta; sodi ...... |
Chromosomal Location | 11q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SCN2B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | SCN2B |
Name | sodium channel, voltage gated, type II beta subunit |
Aliases | sodium channel, voltage-gated, type II, beta polypeptide; sodium channel, voltage-gated, type II, beta; sodi ...... |
Chromosomal Location | 11q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SCN2B in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SCN2B |
Name | sodium channel, voltage gated, type II beta subunit |
Aliases | sodium channel, voltage-gated, type II, beta polypeptide; sodium channel, voltage-gated, type II, beta; sodi ...... |
Chromosomal Location | 11q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SCN2B in various data sets.
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Points in the above scatter plot represent the mutation difference of SCN2B in various data sets.
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Summary | |
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Symbol | SCN2B |
Name | sodium channel, voltage gated, type II beta subunit |
Aliases | sodium channel, voltage-gated, type II, beta polypeptide; sodium channel, voltage-gated, type II, beta; sodi ...... |
Chromosomal Location | 11q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SCN2B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | SCN2B |
Name | sodium channel, voltage gated, type II beta subunit |
Aliases | sodium channel, voltage-gated, type II, beta polypeptide; sodium channel, voltage-gated, type II, beta; sodi ...... |
Chromosomal Location | 11q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SCN2B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SCN2B. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SCN2B |
Name | sodium channel, voltage gated, type II beta subunit |
Aliases | sodium channel, voltage-gated, type II, beta polypeptide; sodium channel, voltage-gated, type II, beta; sodi ...... |
Chromosomal Location | 11q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SCN2B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | SCN2B |
Name | sodium channel, voltage gated, type II beta subunit |
Aliases | sodium channel, voltage-gated, type II, beta polypeptide; sodium channel, voltage-gated, type II, beta; sodi ...... |
Chromosomal Location | 11q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SCN2B expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | SCN2B |
Name | sodium channel, voltage gated, type II beta subunit |
Aliases | sodium channel, voltage-gated, type II, beta polypeptide; sodium channel, voltage-gated, type II, beta; sodi ...... |
Chromosomal Location | 11q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SCN2B and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | SCN2B |
Name | sodium channel, voltage gated, type II beta subunit |
Aliases | sodium channel, voltage-gated, type II, beta polypeptide; sodium channel, voltage-gated, type II, beta; sodi ...... |
Chromosomal Location | 11q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SCN2B collected from DrugBank database. |
Details on drugs targeting SCN2B.
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