Browse SCN8A

Summary
SymbolSCN8A
Namesodium channel, voltage gated, type VIII alpha subunit
Aliases Nav1.6; NaCh6; PN4; CerIII; sodium channel, voltage gated, type VIII, alpha polypeptide; sodium channel, vol ......
Chromosomal Location12q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Multi-pass membrane protein ; SUBCELLULAR LOCATION: Isoform 5: Cytoplasmic vesicle. Note=Some vesicles are localized adjacent to melanoma invadopodia and macrophage podosomes. Does not localize to the plasma membrane.
Domain PF00520 Ion transport protein
PF00612 IQ calmodulin-binding motif
PF06512 Sodium ion transport-associated
PF11933 Cytoplasmic domain of voltage-gated Na+ ion channel
Function

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. In macrophages and melanoma cells, isoform 5 may participate in the control of podosome and invadopodia formation.

> Gene Ontology
 
Biological Process GO:0001508 action potential
GO:0006814 sodium ion transport
GO:0007272 ensheathment of neurons
GO:0007422 peripheral nervous system development
GO:0008366 axon ensheathment
GO:0015672 monovalent inorganic cation transport
GO:0019226 transmission of nerve impulse
GO:0019228 neuronal action potential
GO:0034762 regulation of transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0035637 multicellular organismal signaling
GO:0035725 sodium ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0042552 myelination
GO:0051899 membrane depolarization
GO:0060078 regulation of postsynaptic membrane potential
GO:0086010 membrane depolarization during action potential
Molecular Function GO:0005216 ion channel activity
GO:0005244 voltage-gated ion channel activity
GO:0005248 voltage-gated sodium channel activity
GO:0005261 cation channel activity
GO:0005272 sodium channel activity
GO:0015077 monovalent inorganic cation transmembrane transporter activity
GO:0015081 sodium ion transmembrane transporter activity
GO:0015267 channel activity
GO:0022803 passive transmembrane transporter activity
GO:0022832 voltage-gated channel activity
GO:0022836 gated channel activity
GO:0022838 substrate-specific channel activity
GO:0046873 metal ion transmembrane transporter activity
GO:1905030 voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential
Cellular Component GO:0001518 voltage-gated sodium channel complex
GO:0030016 myofibril
GO:0030017 sarcomere
GO:0030018 Z disc
GO:0030424 axon
GO:0031674 I band
GO:0033267 axon part
GO:0033268 node of Ranvier
GO:0034702 ion channel complex
GO:0034703 cation channel complex
GO:0034706 sodium channel complex
GO:0043194 axon initial segment
GO:0043292 contractile fiber
GO:0044304 main axon
GO:0044449 contractile fiber part
GO:1902495 transmembrane transporter complex
GO:1990351 transporter complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-422475: Axon guidance
R-HSA-5576891: Cardiac conduction
R-HSA-1266738: Developmental Biology
R-HSA-445095: Interaction between L1 and Ankyrins
R-HSA-373760: L1CAM interactions
R-HSA-397014: Muscle contraction
R-HSA-5576892: Phase 0 - rapid depolarisation
Summary
SymbolSCN8A
Namesodium channel, voltage gated, type VIII alpha subunit
Aliases Nav1.6; NaCh6; PN4; CerIII; sodium channel, voltage gated, type VIII, alpha polypeptide; sodium channel, vol ......
Chromosomal Location12q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SCN8A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolSCN8A
Namesodium channel, voltage gated, type VIII alpha subunit
Aliases Nav1.6; NaCh6; PN4; CerIII; sodium channel, voltage gated, type VIII, alpha polypeptide; sodium channel, vol ......
Chromosomal Location12q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SCN8A in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolSCN8A
Namesodium channel, voltage gated, type VIII alpha subunit
Aliases Nav1.6; NaCh6; PN4; CerIII; sodium channel, voltage gated, type VIII, alpha polypeptide; sodium channel, vol ......
Chromosomal Location12q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SCN8A in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0170.943
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.4960.284
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.3940.302
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.5810.171
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.4590.767
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.740.722
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.3450.565
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.9470.34
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.240.814
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.5330.3
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.620.362
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.4790.0305
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of SCN8A in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141728.6028.60.0318
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103400400.497
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.407.40.0709
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.407.40.096
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.85.9-1.11
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.79.1-1.41
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59200200.357
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.109.10.519
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolSCN8A
Namesodium channel, voltage gated, type VIII alpha subunit
Aliases Nav1.6; NaCh6; PN4; CerIII; sodium channel, voltage gated, type VIII, alpha polypeptide; sodium channel, vol ......
Chromosomal Location12q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SCN8A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSCN8A
Namesodium channel, voltage gated, type VIII alpha subunit
Aliases Nav1.6; NaCh6; PN4; CerIII; sodium channel, voltage gated, type VIII, alpha polypeptide; sodium channel, vol ......
Chromosomal Location12q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SCN8A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SCN8A.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSCN8A
Namesodium channel, voltage gated, type VIII alpha subunit
Aliases Nav1.6; NaCh6; PN4; CerIII; sodium channel, voltage gated, type VIII, alpha polypeptide; sodium channel, vol ......
Chromosomal Location12q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SCN8A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSCN8A
Namesodium channel, voltage gated, type VIII alpha subunit
Aliases Nav1.6; NaCh6; PN4; CerIII; sodium channel, voltage gated, type VIII, alpha polypeptide; sodium channel, vol ......
Chromosomal Location12q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SCN8A expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSCN8A
Namesodium channel, voltage gated, type VIII alpha subunit
Aliases Nav1.6; NaCh6; PN4; CerIII; sodium channel, voltage gated, type VIII, alpha polypeptide; sodium channel, vol ......
Chromosomal Location12q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SCN8A and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSCN8A
Namesodium channel, voltage gated, type VIII alpha subunit
Aliases Nav1.6; NaCh6; PN4; CerIII; sodium channel, voltage gated, type VIII, alpha polypeptide; sodium channel, vol ......
Chromosomal Location12q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SCN8A collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting SCN8A.
ID Name Drug Type Targets #Targets
DB00313Valproic AcidSmall MoleculeABAT, ACADSB, ALDH5A1, HDAC2, HDAC9, OGDH, PPARA, PPARD, PPARG, SC ......23
DB05232TetrodotoxinSmall MoleculeSCN1A, SCN2A, SCN3A, SCN8A4
DB05541BrivaracetamSmall MoleculeSCN10A, SCN11A, SCN1A, SCN1B, SCN2A, SCN2B, SCN3A, SCN3B, SCN4A, S ......15