Summary | |
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Symbol | SDR16C5 |
Name | short chain dehydrogenase/reductase family 16C, member 5 |
Aliases | RDHE2; RDH#2; EPHD-2; epidermal retinal dehydrogenase 2; retinal short chain dehydrogenase reductase; retina ...... |
Chromosomal Location | 8q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Endoplasmic reticulum membrane Multi-pass membrane protein |
Domain |
PF00106 short chain dehydrogenase |
Function |
Oxidoreductase with strong preference for NAD. Active in both the oxidative and reductive directions. Oxidizes all-trans-retinol in all-trans-retinaldehyde. No activity was detected with 11-cis-retinol or 11-cis-retinaldehyde as substrates with either NAD(+)/NADH or NADP(+)/NADPH. |
Biological Process |
GO:0001523 retinoid metabolic process GO:0006066 alcohol metabolic process GO:0006081 cellular aldehyde metabolic process GO:0006720 isoprenoid metabolic process GO:0006721 terpenoid metabolic process GO:0007601 visual perception GO:0009314 response to radiation GO:0009416 response to light stimulus GO:0009581 detection of external stimulus GO:0009582 detection of abiotic stimulus GO:0009583 detection of light stimulus GO:0009584 detection of visible light GO:0010817 regulation of hormone levels GO:0016101 diterpenoid metabolic process GO:0034308 primary alcohol metabolic process GO:0034754 cellular hormone metabolic process GO:0042445 hormone metabolic process GO:0042572 retinol metabolic process GO:0042574 retinal metabolic process GO:0043616 keratinocyte proliferation GO:0050673 epithelial cell proliferation GO:0050908 detection of light stimulus involved in visual perception GO:0050953 sensory perception of light stimulus GO:0050962 detection of light stimulus involved in sensory perception GO:1901615 organic hydroxy compound metabolic process |
Molecular Function |
GO:0004745 retinol dehydrogenase activity GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
Cellular Component | - |
KEGG |
hsa00830 Retinol metabolism |
Reactome |
R-HSA-5365859: RA biosynthesis pathway R-HSA-162582: Signal Transduction R-HSA-5362517: Signaling by Retinoic Acid |
Summary | |
---|---|
Symbol | SDR16C5 |
Name | short chain dehydrogenase/reductase family 16C, member 5 |
Aliases | RDHE2; RDH#2; EPHD-2; epidermal retinal dehydrogenase 2; retinal short chain dehydrogenase reductase; retina ...... |
Chromosomal Location | 8q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SDR16C5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SDR16C5 |
Name | short chain dehydrogenase/reductase family 16C, member 5 |
Aliases | RDHE2; RDH#2; EPHD-2; epidermal retinal dehydrogenase 2; retinal short chain dehydrogenase reductase; retina ...... |
Chromosomal Location | 8q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SDR16C5 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SDR16C5 |
Name | short chain dehydrogenase/reductase family 16C, member 5 |
Aliases | RDHE2; RDH#2; EPHD-2; epidermal retinal dehydrogenase 2; retinal short chain dehydrogenase reductase; retina ...... |
Chromosomal Location | 8q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SDR16C5 in various data sets.
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Points in the above scatter plot represent the mutation difference of SDR16C5 in various data sets.
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Summary | |
---|---|
Symbol | SDR16C5 |
Name | short chain dehydrogenase/reductase family 16C, member 5 |
Aliases | RDHE2; RDH#2; EPHD-2; epidermal retinal dehydrogenase 2; retinal short chain dehydrogenase reductase; retina ...... |
Chromosomal Location | 8q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SDR16C5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | SDR16C5 |
Name | short chain dehydrogenase/reductase family 16C, member 5 |
Aliases | RDHE2; RDH#2; EPHD-2; epidermal retinal dehydrogenase 2; retinal short chain dehydrogenase reductase; retina ...... |
Chromosomal Location | 8q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SDR16C5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SDR16C5. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | SDR16C5 |
Name | short chain dehydrogenase/reductase family 16C, member 5 |
Aliases | RDHE2; RDH#2; EPHD-2; epidermal retinal dehydrogenase 2; retinal short chain dehydrogenase reductase; retina ...... |
Chromosomal Location | 8q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SDR16C5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | SDR16C5 |
Name | short chain dehydrogenase/reductase family 16C, member 5 |
Aliases | RDHE2; RDH#2; EPHD-2; epidermal retinal dehydrogenase 2; retinal short chain dehydrogenase reductase; retina ...... |
Chromosomal Location | 8q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SDR16C5 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SDR16C5 |
Name | short chain dehydrogenase/reductase family 16C, member 5 |
Aliases | RDHE2; RDH#2; EPHD-2; epidermal retinal dehydrogenase 2; retinal short chain dehydrogenase reductase; retina ...... |
Chromosomal Location | 8q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SDR16C5 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SDR16C5 |
Name | short chain dehydrogenase/reductase family 16C, member 5 |
Aliases | RDHE2; RDH#2; EPHD-2; epidermal retinal dehydrogenase 2; retinal short chain dehydrogenase reductase; retina ...... |
Chromosomal Location | 8q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SDR16C5 collected from DrugBank database. |
There is no record. |