Browse SEC22A

Summary
SymbolSEC22A
NameSEC22 homolog A, vesicle trafficking protein
Aliases SEC22L2; SEC22 vesicle trafficking protein-like 2 (S. cerevisiae); SEC22 vesicle trafficking protein homolog ......
Chromosomal Location3q21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Endoplasmic reticulum membrane Multi-pass membrane protein
Domain PF13774 Regulated-SNARE-like domain
Function

May be involved in vesicle transport between the ER and the Golgi complex.

> Gene Ontology
 
Biological Process GO:0006888 ER to Golgi vesicle-mediated transport
GO:0006906 vesicle fusion
GO:0016050 vesicle organization
GO:0044801 single-organism membrane fusion
GO:0048193 Golgi vesicle transport
GO:0048280 vesicle fusion with Golgi apparatus
GO:0048284 organelle fusion
GO:0061025 membrane fusion
GO:0090174 organelle membrane fusion
Molecular Function GO:0000149 SNARE binding
GO:0005484 SNAP receptor activity
Cellular Component GO:0031201 SNARE complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-446203: Asparagine N-linked glycosylation
R-HSA-204005: COPII (Coat Protein 2) Mediated Vesicle Transport
R-HSA-199977: ER to Golgi Anterograde Transport
R-HSA-199991: Membrane Trafficking
R-HSA-392499: Metabolism of proteins
R-HSA-597592: Post-translational protein modification
R-HSA-948021: Transport to the Golgi and subsequent modification
R-HSA-5653656: Vesicle-mediated transport
Summary
SymbolSEC22A
NameSEC22 homolog A, vesicle trafficking protein
Aliases SEC22L2; SEC22 vesicle trafficking protein-like 2 (S. cerevisiae); SEC22 vesicle trafficking protein homolog ......
Chromosomal Location3q21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SEC22A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolSEC22A
NameSEC22 homolog A, vesicle trafficking protein
Aliases SEC22L2; SEC22 vesicle trafficking protein-like 2 (S. cerevisiae); SEC22 vesicle trafficking protein homolog ......
Chromosomal Location3q21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SEC22A in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell logFC: 0.72; FDR: 0.041900 Sensitive to T cell-mediated killing
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolSEC22A
NameSEC22 homolog A, vesicle trafficking protein
Aliases SEC22L2; SEC22 vesicle trafficking protein-like 2 (S. cerevisiae); SEC22 vesicle trafficking protein homolog ......
Chromosomal Location3q21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SEC22A in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1880.286
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.4210.736
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.0210.98
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.1160.786
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.3320.786
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.6840.653
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.130.698
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.1150.927
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.1530.913
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.1610.913
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.4890.821
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.1670.00079
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of SEC22A in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.71.42.30.469
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolSEC22A
NameSEC22 homolog A, vesicle trafficking protein
Aliases SEC22L2; SEC22 vesicle trafficking protein-like 2 (S. cerevisiae); SEC22 vesicle trafficking protein homolog ......
Chromosomal Location3q21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SEC22A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSEC22A
NameSEC22 homolog A, vesicle trafficking protein
Aliases SEC22L2; SEC22 vesicle trafficking protein-like 2 (S. cerevisiae); SEC22 vesicle trafficking protein homolog ......
Chromosomal Location3q21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SEC22A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SEC22A.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSEC22A
NameSEC22 homolog A, vesicle trafficking protein
Aliases SEC22L2; SEC22 vesicle trafficking protein-like 2 (S. cerevisiae); SEC22 vesicle trafficking protein homolog ......
Chromosomal Location3q21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SEC22A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSEC22A
NameSEC22 homolog A, vesicle trafficking protein
Aliases SEC22L2; SEC22 vesicle trafficking protein-like 2 (S. cerevisiae); SEC22 vesicle trafficking protein homolog ......
Chromosomal Location3q21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SEC22A expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSEC22A
NameSEC22 homolog A, vesicle trafficking protein
Aliases SEC22L2; SEC22 vesicle trafficking protein-like 2 (S. cerevisiae); SEC22 vesicle trafficking protein homolog ......
Chromosomal Location3q21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SEC22A and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSEC22A
NameSEC22 homolog A, vesicle trafficking protein
Aliases SEC22L2; SEC22 vesicle trafficking protein-like 2 (S. cerevisiae); SEC22 vesicle trafficking protein homolog ......
Chromosomal Location3q21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SEC22A collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.