Summary | |
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Symbol | SEC22A |
Name | SEC22 homolog A, vesicle trafficking protein |
Aliases | SEC22L2; SEC22 vesicle trafficking protein-like 2 (S. cerevisiae); SEC22 vesicle trafficking protein homolog ...... |
Chromosomal Location | 3q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Endoplasmic reticulum membrane Multi-pass membrane protein |
Domain |
PF13774 Regulated-SNARE-like domain |
Function |
May be involved in vesicle transport between the ER and the Golgi complex. |
Biological Process |
GO:0006888 ER to Golgi vesicle-mediated transport GO:0006906 vesicle fusion GO:0016050 vesicle organization GO:0044801 single-organism membrane fusion GO:0048193 Golgi vesicle transport GO:0048280 vesicle fusion with Golgi apparatus GO:0048284 organelle fusion GO:0061025 membrane fusion GO:0090174 organelle membrane fusion |
Molecular Function |
GO:0000149 SNARE binding GO:0005484 SNAP receptor activity |
Cellular Component |
GO:0031201 SNARE complex |
KEGG | - |
Reactome |
R-HSA-446203: Asparagine N-linked glycosylation R-HSA-204005: COPII (Coat Protein 2) Mediated Vesicle Transport R-HSA-199977: ER to Golgi Anterograde Transport R-HSA-199991: Membrane Trafficking R-HSA-392499: Metabolism of proteins R-HSA-597592: Post-translational protein modification R-HSA-948021: Transport to the Golgi and subsequent modification R-HSA-5653656: Vesicle-mediated transport |
Summary | |
---|---|
Symbol | SEC22A |
Name | SEC22 homolog A, vesicle trafficking protein |
Aliases | SEC22L2; SEC22 vesicle trafficking protein-like 2 (S. cerevisiae); SEC22 vesicle trafficking protein homolog ...... |
Chromosomal Location | 3q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SEC22A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SEC22A |
Name | SEC22 homolog A, vesicle trafficking protein |
Aliases | SEC22L2; SEC22 vesicle trafficking protein-like 2 (S. cerevisiae); SEC22 vesicle trafficking protein homolog ...... |
Chromosomal Location | 3q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SEC22A in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | SEC22A |
Name | SEC22 homolog A, vesicle trafficking protein |
Aliases | SEC22L2; SEC22 vesicle trafficking protein-like 2 (S. cerevisiae); SEC22 vesicle trafficking protein homolog ...... |
Chromosomal Location | 3q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SEC22A in various data sets.
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Points in the above scatter plot represent the mutation difference of SEC22A in various data sets.
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Summary | |
---|---|
Symbol | SEC22A |
Name | SEC22 homolog A, vesicle trafficking protein |
Aliases | SEC22L2; SEC22 vesicle trafficking protein-like 2 (S. cerevisiae); SEC22 vesicle trafficking protein homolog ...... |
Chromosomal Location | 3q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SEC22A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | SEC22A |
Name | SEC22 homolog A, vesicle trafficking protein |
Aliases | SEC22L2; SEC22 vesicle trafficking protein-like 2 (S. cerevisiae); SEC22 vesicle trafficking protein homolog ...... |
Chromosomal Location | 3q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SEC22A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SEC22A. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | SEC22A |
Name | SEC22 homolog A, vesicle trafficking protein |
Aliases | SEC22L2; SEC22 vesicle trafficking protein-like 2 (S. cerevisiae); SEC22 vesicle trafficking protein homolog ...... |
Chromosomal Location | 3q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SEC22A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | SEC22A |
Name | SEC22 homolog A, vesicle trafficking protein |
Aliases | SEC22L2; SEC22 vesicle trafficking protein-like 2 (S. cerevisiae); SEC22 vesicle trafficking protein homolog ...... |
Chromosomal Location | 3q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SEC22A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SEC22A |
Name | SEC22 homolog A, vesicle trafficking protein |
Aliases | SEC22L2; SEC22 vesicle trafficking protein-like 2 (S. cerevisiae); SEC22 vesicle trafficking protein homolog ...... |
Chromosomal Location | 3q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SEC22A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SEC22A |
Name | SEC22 homolog A, vesicle trafficking protein |
Aliases | SEC22L2; SEC22 vesicle trafficking protein-like 2 (S. cerevisiae); SEC22 vesicle trafficking protein homolog ...... |
Chromosomal Location | 3q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SEC22A collected from DrugBank database. |
There is no record. |