Summary | |
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Symbol | SEC23B |
Name | Sec23 homolog B, COPII coat complex component |
Aliases | CDA-II; CDAII; HEMPAS; CDAN2; Sec23 (S. cerevisiae) homolog B; congenital dyserythropoietic anemia, type II; ...... |
Chromosomal Location | 20p11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasmic vesicle, COPII-coated vesicle membrane Peripheral membrane protein Cytoplasmic side Endoplasmic reticulum membrane Peripheral membrane protein Cytoplasmic side Cytoplasm, cytosol |
Domain |
PF00626 Gelsolin repeat PF08033 Sec23/Sec24 beta-sandwich domain PF04815 Sec23/Sec24 helical domain PF04811 Sec23/Sec24 trunk domain PF04810 Sec23/Sec24 zinc finger |
Function |
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. |
Biological Process |
GO:0006888 ER to Golgi vesicle-mediated transport GO:0048193 Golgi vesicle transport |
Molecular Function | - |
Cellular Component |
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment GO:0012507 ER to Golgi transport vesicle membrane GO:0030117 membrane coat GO:0030120 vesicle coat GO:0030127 COPII vesicle coat GO:0030133 transport vesicle GO:0030134 ER to Golgi transport vesicle GO:0030135 coated vesicle GO:0030658 transport vesicle membrane GO:0030659 cytoplasmic vesicle membrane GO:0030662 coated vesicle membrane GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane GO:0048475 coated membrane |
KEGG |
hsa04141 Protein processing in endoplasmic reticulum |
Reactome | - |
Summary | |
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Symbol | SEC23B |
Name | Sec23 homolog B, COPII coat complex component |
Aliases | CDA-II; CDAII; HEMPAS; CDAN2; Sec23 (S. cerevisiae) homolog B; congenital dyserythropoietic anemia, type II; ...... |
Chromosomal Location | 20p11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SEC23B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SEC23B |
Name | Sec23 homolog B, COPII coat complex component |
Aliases | CDA-II; CDAII; HEMPAS; CDAN2; Sec23 (S. cerevisiae) homolog B; congenital dyserythropoietic anemia, type II; ...... |
Chromosomal Location | 20p11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SEC23B in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SEC23B |
Name | Sec23 homolog B, COPII coat complex component |
Aliases | CDA-II; CDAII; HEMPAS; CDAN2; Sec23 (S. cerevisiae) homolog B; congenital dyserythropoietic anemia, type II; ...... |
Chromosomal Location | 20p11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SEC23B in various data sets.
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Points in the above scatter plot represent the mutation difference of SEC23B in various data sets.
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Summary | |
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Symbol | SEC23B |
Name | Sec23 homolog B, COPII coat complex component |
Aliases | CDA-II; CDAII; HEMPAS; CDAN2; Sec23 (S. cerevisiae) homolog B; congenital dyserythropoietic anemia, type II; ...... |
Chromosomal Location | 20p11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SEC23B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | SEC23B |
Name | Sec23 homolog B, COPII coat complex component |
Aliases | CDA-II; CDAII; HEMPAS; CDAN2; Sec23 (S. cerevisiae) homolog B; congenital dyserythropoietic anemia, type II; ...... |
Chromosomal Location | 20p11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SEC23B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SEC23B. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SEC23B |
Name | Sec23 homolog B, COPII coat complex component |
Aliases | CDA-II; CDAII; HEMPAS; CDAN2; Sec23 (S. cerevisiae) homolog B; congenital dyserythropoietic anemia, type II; ...... |
Chromosomal Location | 20p11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SEC23B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | SEC23B |
Name | Sec23 homolog B, COPII coat complex component |
Aliases | CDA-II; CDAII; HEMPAS; CDAN2; Sec23 (S. cerevisiae) homolog B; congenital dyserythropoietic anemia, type II; ...... |
Chromosomal Location | 20p11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SEC23B expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | SEC23B |
Name | Sec23 homolog B, COPII coat complex component |
Aliases | CDA-II; CDAII; HEMPAS; CDAN2; Sec23 (S. cerevisiae) homolog B; congenital dyserythropoietic anemia, type II; ...... |
Chromosomal Location | 20p11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SEC23B and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | SEC23B |
Name | Sec23 homolog B, COPII coat complex component |
Aliases | CDA-II; CDAII; HEMPAS; CDAN2; Sec23 (S. cerevisiae) homolog B; congenital dyserythropoietic anemia, type II; ...... |
Chromosomal Location | 20p11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SEC23B collected from DrugBank database. |
There is no record. |