TISIDB

Summary
Symbol	SEC61A1
Name	Sec61 translocon alpha 1 subunit
Aliases	Sec61 alpha 1 subunit (S. cerevisiae); HSEC61; SEC61; SEC61A; Sec61 alpha 1 subunit; Sec61 alpha-1; protein ......
Chromosomal Location	3q21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Endoplasmic reticulum membrane Multi-pass membrane protein Note=Localizes exclusively in granular structures in the endoplasmic reticulum (ER).
Domain	PF10559 Plug domain of Sec61p PF00344 SecY translocase
Function	Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER (PubMed:28782633). Required for assembly of membrane and secretory proteins. Tightly associated with membrane-bound ribosomes, either directly or through adapter proteins. Plays a role in pronephric kidney tubule development (By similarity).

> Gene Ontology [ TOP ]
Biological Process	GO:0006612 protein targeting to membrane GO:0006613 cotranslational protein targeting to membrane GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0006620 posttranslational protein targeting to membrane GO:0006986 response to unfolded protein GO:0007029 endoplasmic reticulum organization GO:0016049 cell growth GO:0030968 endoplasmic reticulum unfolded protein response GO:0034341 response to interferon-gamma GO:0034620 cellular response to unfolded protein GO:0034976 response to endoplasmic reticulum stress GO:0035966 response to topologically incorrect protein GO:0035967 cellular response to topologically incorrect protein GO:0036498 IRE1-mediated unfolded protein response GO:0045047 protein targeting to ER GO:0070972 protein localization to endoplasmic reticulum GO:0072599 establishment of protein localization to endoplasmic reticulum GO:0072657 protein localization to membrane GO:0090150 establishment of protein localization to membrane
Molecular Function	GO:0043021 ribonucleoprotein complex binding GO:0043022 ribosome binding
Cellular Component	GO:0005791 rough endoplasmic reticulum GO:0030176 integral component of endoplasmic reticulum membrane GO:0031227 intrinsic component of endoplasmic reticulum membrane

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa03060 Protein export hsa04141 Protein processing in endoplasmic reticulum hsa04145 Phagosome
Reactome	R-HSA-1280218: Adaptive Immune System R-HSA-1236975: Antigen processing-Cross presentation R-HSA-983169: Class I MHC mediated antigen processing & presentation R-HSA-1236974: ER-Phagosome pathway R-HSA-74160: Gene Expression R-HSA-381070: IRE1alpha activates chaperones R-HSA-168256: Immune System R-HSA-392499: Metabolism of proteins R-HSA-1799339: SRP-dependent cotranslational protein targeting to membrane R-HSA-72766: Translation R-HSA-381119: Unfolded Protein Response (UPR) R-HSA-381038: XBP1(S) activates chaperone genes

> KEGG and Reactome Pathway

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KEGG

hsa03060 Protein export
hsa04141 Protein processing in endoplasmic reticulum
hsa04145 Phagosome

Reactome

R-HSA-1280218: Adaptive Immune System
R-HSA-1236975: Antigen processing-Cross presentation
R-HSA-983169: Class I MHC mediated antigen processing & presentation
R-HSA-1236974: ER-Phagosome pathway
R-HSA-74160: Gene Expression
R-HSA-381070: IRE1alpha activates chaperones
R-HSA-168256: Immune System
R-HSA-392499: Metabolism of proteins
R-HSA-1799339: SRP-dependent cotranslational protein targeting to membrane
R-HSA-72766: Translation
R-HSA-381119: Unfolded Protein Response (UPR)
R-HSA-381038: XBP1(S) activates chaperone genes

Summary
Symbol	SEC61A1
Name	Sec61 translocon alpha 1 subunit
Aliases	Sec61 alpha 1 subunit (S. cerevisiae); HSEC61; SEC61; SEC61A; Sec61 alpha 1 subunit; Sec61 alpha-1; protein ......
Chromosomal Location	3q21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between SEC61A1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	SEC61A1
Name	Sec61 translocon alpha 1 subunit
Aliases	Sec61 alpha 1 subunit (S. cerevisiae); HSEC61; SEC61; SEC61A; Sec61 alpha 1 subunit; Sec61 alpha-1; protein ......
Chromosomal Location	3q21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of SEC61A1 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	Second most enriched score: 0.93	Sensitive to T cell-mediated killing
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	SEC61A1
Name	Sec61 translocon alpha 1 subunit
Aliases	Sec61 alpha 1 subunit (S. cerevisiae); HSEC61; SEC61; SEC61A; Sec61 alpha 1 subunit; Sec61 alpha-1; protein ......
Chromosomal Location	3q21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of SEC61A1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.14	0.453
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.068	0.983
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.291	0.903
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.269	0.481
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.166	0.94
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.403	0.89
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.062	0.907
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.137	0.951
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.265	0.917
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.172	0.94
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.418	0.904
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.131	0.0198

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of SEC61A1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	3.7	0	3.7	0.27
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	3.7	0	3.7	0.314
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	6.2	-6.2	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	11.1	-11.1	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	SEC61A1
Name	Sec61 translocon alpha 1 subunit
Aliases	Sec61 alpha 1 subunit (S. cerevisiae); HSEC61; SEC61; SEC61A; Sec61 alpha 1 subunit; Sec61 alpha-1; protein ......
Chromosomal Location	3q21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SEC61A1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	SEC61A1
Name	Sec61 translocon alpha 1 subunit
Aliases	Sec61 alpha 1 subunit (S. cerevisiae); HSEC61; SEC61; SEC61A; Sec61 alpha 1 subunit; Sec61 alpha-1; protein ......
Chromosomal Location	3q21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SEC61A1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SEC61A1. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	SEC61A1
Name	Sec61 translocon alpha 1 subunit
Aliases	Sec61 alpha 1 subunit (S. cerevisiae); HSEC61; SEC61; SEC61A; Sec61 alpha 1 subunit; Sec61 alpha-1; protein ......
Chromosomal Location	3q21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SEC61A1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	SEC61A1
Name	Sec61 translocon alpha 1 subunit
Aliases	Sec61 alpha 1 subunit (S. cerevisiae); HSEC61; SEC61; SEC61A; Sec61 alpha 1 subunit; Sec61 alpha-1; protein ......
Chromosomal Location	3q21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of SEC61A1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	SEC61A1
Name	Sec61 translocon alpha 1 subunit
Aliases	Sec61 alpha 1 subunit (S. cerevisiae); HSEC61; SEC61; SEC61A; Sec61 alpha 1 subunit; Sec61 alpha-1; protein ......
Chromosomal Location	3q21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between SEC61A1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	SEC61A1
Name	Sec61 translocon alpha 1 subunit
Aliases	Sec61 alpha 1 subunit (S. cerevisiae); HSEC61; SEC61; SEC61A; Sec61 alpha 1 subunit; Sec61 alpha-1; protein ......
Chromosomal Location	3q21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting SEC61A1 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

Browse SEC61A1