Summary | |
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Symbol | SELL |
Name | selectin L |
Aliases | LSEL; LAM1; LAM-1; hLHRc; Leu-8; Lyam-1; PLNHR; CD62L; LYAM1; LNHR; lymphocyte adhesion molecule 1; LECAM1; ...... |
Chromosomal Location | 1q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass type I membrane protein |
Domain |
PF00059 Lectin C-type domain PF00084 Sushi repeat (SCR repeat) |
Function |
Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells (PubMed:12403782, PubMed:28489325, PubMed:28011641). Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (PubMed:12403782, PubMed:28011641). |
Biological Process |
GO:0014074 response to purine-containing compound GO:0033198 response to ATP GO:0046683 response to organophosphorus GO:0050900 leukocyte migration |
Molecular Function |
GO:0002020 protease binding GO:0005539 glycosaminoglycan binding GO:0008201 heparin binding GO:0030246 carbohydrate binding GO:0043208 glycosphingolipid binding GO:0046625 sphingolipid binding GO:0050839 cell adhesion molecule binding GO:0051861 glycolipid binding GO:1901681 sulfur compound binding |
Cellular Component |
GO:0009897 external side of plasma membrane GO:0098552 side of membrane |
KEGG |
hsa04514 Cell adhesion molecules (CAMs) |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-202733: Cell surface interactions at the vascular wall R-HSA-109582: Hemostasis R-HSA-168256: Immune System R-HSA-198933: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-168249: Innate Immune System R-HSA-6798695: Neutrophil degranulation |
Summary | |
---|---|
Symbol | SELL |
Name | selectin L |
Aliases | LSEL; LAM1; LAM-1; hLHRc; Leu-8; Lyam-1; PLNHR; CD62L; LYAM1; LNHR; lymphocyte adhesion molecule 1; LECAM1; ...... |
Chromosomal Location | 1q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SELL and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between SELL and anti-tumor immunity in human cancer.
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Summary | |
---|---|
Symbol | SELL |
Name | selectin L |
Aliases | LSEL; LAM1; LAM-1; hLHRc; Leu-8; Lyam-1; PLNHR; CD62L; LYAM1; LNHR; lymphocyte adhesion molecule 1; LECAM1; ...... |
Chromosomal Location | 1q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SELL in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | SELL |
Name | selectin L |
Aliases | LSEL; LAM1; LAM-1; hLHRc; Leu-8; Lyam-1; PLNHR; CD62L; LYAM1; LNHR; lymphocyte adhesion molecule 1; LECAM1; ...... |
Chromosomal Location | 1q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SELL in various data sets.
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Points in the above scatter plot represent the mutation difference of SELL in various data sets.
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Summary | |
---|---|
Symbol | SELL |
Name | selectin L |
Aliases | LSEL; LAM1; LAM-1; hLHRc; Leu-8; Lyam-1; PLNHR; CD62L; LYAM1; LNHR; lymphocyte adhesion molecule 1; LECAM1; ...... |
Chromosomal Location | 1q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SELL. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | SELL |
Name | selectin L |
Aliases | LSEL; LAM1; LAM-1; hLHRc; Leu-8; Lyam-1; PLNHR; CD62L; LYAM1; LNHR; lymphocyte adhesion molecule 1; LECAM1; ...... |
Chromosomal Location | 1q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SELL. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SELL. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | SELL |
Name | selectin L |
Aliases | LSEL; LAM1; LAM-1; hLHRc; Leu-8; Lyam-1; PLNHR; CD62L; LYAM1; LNHR; lymphocyte adhesion molecule 1; LECAM1; ...... |
Chromosomal Location | 1q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SELL. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | SELL |
Name | selectin L |
Aliases | LSEL; LAM1; LAM-1; hLHRc; Leu-8; Lyam-1; PLNHR; CD62L; LYAM1; LNHR; lymphocyte adhesion molecule 1; LECAM1; ...... |
Chromosomal Location | 1q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SELL expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SELL |
Name | selectin L |
Aliases | LSEL; LAM1; LAM-1; hLHRc; Leu-8; Lyam-1; PLNHR; CD62L; LYAM1; LNHR; lymphocyte adhesion molecule 1; LECAM1; ...... |
Chromosomal Location | 1q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SELL and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SELL |
Name | selectin L |
Aliases | LSEL; LAM1; LAM-1; hLHRc; Leu-8; Lyam-1; PLNHR; CD62L; LYAM1; LNHR; lymphocyte adhesion molecule 1; LECAM1; ...... |
Chromosomal Location | 1q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SELL collected from DrugBank database. |
There is no record. |