Browse SELP

Summary
SymbolSELP
Nameselectin P (granule membrane protein 140kDa, antigen CD62)
Aliases CD62; PSEL; PADGEM; GMP140; CD62P; GRMP; selectin P (granule membrane protein 140kD, antigen CD62); LECAM3; ......
Chromosomal Location1q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Single-pass type I membrane protein
Domain PF00059 Lectin C-type domain
PF00084 Sushi repeat (SCR repeat)
Function

Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG.

> Gene Ontology
 
Biological Process GO:0002237 response to molecule of bacterial origin
GO:0002576 platelet degranulation
GO:0002685 regulation of leukocyte migration
GO:0002687 positive regulation of leukocyte migration
GO:0006887 exocytosis
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0007159 leukocyte cell-cell adhesion
GO:0007596 blood coagulation
GO:0007599 hemostasis
GO:0010543 regulation of platelet activation
GO:0010572 positive regulation of platelet activation
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0019722 calcium-mediated signaling
GO:0019932 second-messenger-mediated signaling
GO:0030168 platelet activation
GO:0030193 regulation of blood coagulation
GO:0030194 positive regulation of blood coagulation
GO:0030335 positive regulation of cell migration
GO:0032496 response to lipopolysaccharide
GO:0033622 integrin activation
GO:0033623 regulation of integrin activation
GO:0035584 calcium-mediated signaling using intracellular calcium source
GO:0040017 positive regulation of locomotion
GO:0042742 defense response to bacterium
GO:0043254 regulation of protein complex assembly
GO:0045055 regulated exocytosis
GO:0045123 cellular extravasation
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048017 inositol lipid-mediated signaling
GO:0050817 coagulation
GO:0050818 regulation of coagulation
GO:0050820 positive regulation of coagulation
GO:0050829 defense response to Gram-negative bacterium
GO:0050865 regulation of cell activation
GO:0050867 positive regulation of cell activation
GO:0050878 regulation of body fluid levels
GO:0050900 leukocyte migration
GO:0050901 leukocyte tethering or rolling
GO:0051272 positive regulation of cellular component movement
GO:0061041 regulation of wound healing
GO:0061756 leukocyte adhesion to vascular endothelial cell
GO:0090303 positive regulation of wound healing
GO:0098542 defense response to other organism
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules
GO:1900046 regulation of hemostasis
GO:1900048 positive regulation of hemostasis
GO:1903034 regulation of response to wounding
GO:1903036 positive regulation of response to wounding
GO:2000147 positive regulation of cell motility
Molecular Function GO:0001530 lipopolysaccharide binding
GO:0001948 glycoprotein binding
GO:0005539 glycosaminoglycan binding
GO:0008201 heparin binding
GO:0030246 carbohydrate binding
GO:0031406 carboxylic acid binding
GO:0033691 sialic acid binding
GO:0042806 fucose binding
GO:0043168 anion binding
GO:0043208 glycosphingolipid binding
GO:0046625 sphingolipid binding
GO:0048029 monosaccharide binding
GO:0048306 calcium-dependent protein binding
GO:0051861 glycolipid binding
GO:0070492 oligosaccharide binding
GO:1901681 sulfur compound binding
Cellular Component GO:0009897 external side of plasma membrane
GO:0030141 secretory granule
GO:0030659 cytoplasmic vesicle membrane
GO:0030667 secretory granule membrane
GO:0031088 platelet dense granule membrane
GO:0031091 platelet alpha granule
GO:0031092 platelet alpha granule membrane
GO:0042827 platelet dense granule
GO:0098552 side of membrane
GO:0099503 secretory vesicle
> KEGG and Reactome Pathway
 
KEGG hsa04514 Cell adhesion molecules (CAMs)
Reactome R-HSA-202733: Cell surface interactions at the vascular wall
R-HSA-109582: Hemostasis
R-HSA-76002: Platelet activation, signaling and aggregation
R-HSA-114608: Platelet degranulation
R-HSA-76005: Response to elevated platelet cytosolic Ca2+
Summary
SymbolSELP
Nameselectin P (granule membrane protein 140kDa, antigen CD62)
Aliases CD62; PSEL; PADGEM; GMP140; CD62P; GRMP; selectin P (granule membrane protein 140kD, antigen CD62); LECAM3; ......
Chromosomal Location1q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SELP and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between SELP and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
17473183Metastatic MelanomaPromote immunity (infiltration)Results show that the majority of metastatic melanoma samples examined do not express the vascular adhesion receptors E-selectin (CD62E), P-selectin (CD62P), and intercellular adhesion molecule-1 (CD54) on vessels within the tumor boundaries. This results in a block to recruitment of activated tumor-specific CTL to melanoma metastases and is a likely factor limiting the effectiveness of current immunotherapy protocols.
21926464MelanomaPromote immunity (infiltration)Inflammatory cytokines such as IL-6 exert tumor-promoting activities by driving growth and survival of neoplastic cells. Mechanistically, IL-6 produced by nonhematopoietic stromal cells acted cooperatively with soluble IL-6 receptor-α and thermally induced gp130 to promote E/P-selectin- and ICAM-1-dependent extravasation of cytotoxic T cells in tumors.
Summary
SymbolSELP
Nameselectin P (granule membrane protein 140kDa, antigen CD62)
Aliases CD62; PSEL; PADGEM; GMP140; CD62P; GRMP; selectin P (granule membrane protein 140kD, antigen CD62); LECAM3; ......
Chromosomal Location1q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SELP in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolSELP
Nameselectin P (granule membrane protein 140kDa, antigen CD62)
Aliases CD62; PSEL; PADGEM; GMP140; CD62P; GRMP; selectin P (granule membrane protein 140kD, antigen CD62); LECAM3; ......
Chromosomal Location1q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SELP in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0110.978
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.0020.998
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.0130.981
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.2080.639
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.8090.554
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.5530.752
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.3010.654
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.3650.73
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.2110.853
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.7310.186
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.9160.29
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.4810.0459
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of SELP in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.74.1-0.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.75.1-1.41
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.509.50.492
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916012.5-12.50.52
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47014.3-14.31
1329033130MelanomaallAnti-PD-1 (nivolumab) 382713.23.79.50.388
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221318.2018.20.274
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.27.1-0.91
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolSELP
Nameselectin P (granule membrane protein 140kDa, antigen CD62)
Aliases CD62; PSEL; PADGEM; GMP140; CD62P; GRMP; selectin P (granule membrane protein 140kD, antigen CD62); LECAM3; ......
Chromosomal Location1q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SELP. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSELP
Nameselectin P (granule membrane protein 140kDa, antigen CD62)
Aliases CD62; PSEL; PADGEM; GMP140; CD62P; GRMP; selectin P (granule membrane protein 140kD, antigen CD62); LECAM3; ......
Chromosomal Location1q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SELP. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SELP.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSELP
Nameselectin P (granule membrane protein 140kDa, antigen CD62)
Aliases CD62; PSEL; PADGEM; GMP140; CD62P; GRMP; selectin P (granule membrane protein 140kD, antigen CD62); LECAM3; ......
Chromosomal Location1q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SELP. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSELP
Nameselectin P (granule membrane protein 140kDa, antigen CD62)
Aliases CD62; PSEL; PADGEM; GMP140; CD62P; GRMP; selectin P (granule membrane protein 140kD, antigen CD62); LECAM3; ......
Chromosomal Location1q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SELP expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSELP
Nameselectin P (granule membrane protein 140kDa, antigen CD62)
Aliases CD62; PSEL; PADGEM; GMP140; CD62P; GRMP; selectin P (granule membrane protein 140kD, antigen CD62); LECAM3; ......
Chromosomal Location1q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SELP and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSELP
Nameselectin P (granule membrane protein 140kDa, antigen CD62)
Aliases CD62; PSEL; PADGEM; GMP140; CD62P; GRMP; selectin P (granule membrane protein 140kD, antigen CD62); LECAM3; ......
Chromosomal Location1q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SELP collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting SELP.
ID Name Drug Type Targets #Targets
DB01109HeparinSmall MoleculeF10, FGF1, FGF19, FGF2, FGF4, FGFR1, FGFR2, FGFR4, HGF, PF4, SELP, ......12
DB03721N-acetyl-alpha-neuraminic acidSmall MoleculeAZGP1, CES1, MBL2, REG1A, SELE, SELP, SIGLEC17
DB06779DalteparinSmall MoleculeSELP, SERPINC1, TFPI, VEGFA4
DB08813NadroparinSmall MoleculeFOS, MYC, SELP, SERPINC14