Summary | |
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Symbol | SEMA3A |
Name | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A |
Aliases | SemD; coll-1; Hsema-I; sema III; SEMAD; COLL1; HH16; Hsema-III; SEMAIII; collapsin 1; semaphorin D; semaphor ...... |
Chromosomal Location | 7p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted |
Domain |
PF01403 Sema domain |
Function |
Involved in the development of the olfactory system and in neuronal control of puberty. Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to the complex neuropilin-1/plexin-1. |
Biological Process |
GO:0001558 regulation of cell growth GO:0001667 ameboidal-type cell migration GO:0001755 neural crest cell migration GO:0001763 morphogenesis of a branching structure GO:0001764 neuron migration GO:0002027 regulation of heart rate GO:0003002 regionalization GO:0003013 circulatory system process GO:0003015 heart process GO:0006929 substrate-dependent cell migration GO:0007350 blastoderm segmentation GO:0007389 pattern specification process GO:0007409 axonogenesis GO:0007411 axon guidance GO:0007413 axonal fasciculation GO:0007431 salivary gland development GO:0007435 salivary gland morphogenesis GO:0007548 sex differentiation GO:0008015 blood circulation GO:0008016 regulation of heart contraction GO:0008037 cell recognition GO:0008038 neuron recognition GO:0008045 motor neuron axon guidance GO:0008361 regulation of cell size GO:0008406 gonad development GO:0008584 male gonad development GO:0009880 embryonic pattern specification GO:0010631 epithelial cell migration GO:0010632 regulation of epithelial cell migration GO:0010633 negative regulation of epithelial cell migration GO:0010720 positive regulation of cell development GO:0010721 negative regulation of cell development GO:0010769 regulation of cell morphogenesis involved in differentiation GO:0010771 negative regulation of cell morphogenesis involved in differentiation GO:0010975 regulation of neuron projection development GO:0010977 negative regulation of neuron projection development GO:0014031 mesenchymal cell development GO:0014032 neural crest cell development GO:0014033 neural crest cell differentiation GO:0016049 cell growth GO:0016358 dendrite development GO:0021536 diencephalon development GO:0021537 telencephalon development GO:0021543 pallium development GO:0021545 cranial nerve development GO:0021559 trigeminal nerve development GO:0021561 facial nerve development GO:0021602 cranial nerve morphogenesis GO:0021604 cranial nerve structural organization GO:0021610 facial nerve morphogenesis GO:0021612 facial nerve structural organization GO:0021636 trigeminal nerve morphogenesis GO:0021637 trigeminal nerve structural organization GO:0021675 nerve development GO:0021761 limbic system development GO:0021772 olfactory bulb development GO:0021783 preganglionic parasympathetic fiber development GO:0021785 branchiomotor neuron axon guidance GO:0021795 cerebral cortex cell migration GO:0021800 cerebral cortex tangential migration GO:0021824 cerebral cortex tangential migration using cell-axon interactions GO:0021825 substrate-dependent cerebral cortex tangential migration GO:0021828 gonadotrophin-releasing hormone neuronal migration to the hypothalamus GO:0021854 hypothalamus development GO:0021855 hypothalamus cell migration GO:0021856 hypothalamic tangential migration using cell-axon interactions GO:0021872 forebrain generation of neurons GO:0021879 forebrain neuron differentiation GO:0021884 forebrain neuron development GO:0021885 forebrain cell migration GO:0021886 hypothalamus gonadotrophin-releasing hormone neuron differentiation GO:0021888 hypothalamus gonadotrophin-releasing hormone neuron development GO:0021953 central nervous system neuron differentiation GO:0021954 central nervous system neuron development GO:0021979 hypothalamus cell differentiation GO:0021987 cerebral cortex development GO:0021988 olfactory lobe development GO:0022029 telencephalon cell migration GO:0022604 regulation of cell morphogenesis GO:0022612 gland morphogenesis GO:0030308 negative regulation of cell growth GO:0030335 positive regulation of cell migration GO:0030336 negative regulation of cell migration GO:0030516 regulation of axon extension GO:0030517 negative regulation of axon extension GO:0030900 forebrain development GO:0031345 negative regulation of cell projection organization GO:0032102 negative regulation of response to external stimulus GO:0032535 regulation of cellular component size GO:0035272 exocrine system development GO:0035282 segmentation GO:0035290 trunk segmentation GO:0036484 trunk neural crest cell migration GO:0036486 ventral trunk neural crest cell migration GO:0040013 negative regulation of locomotion GO:0040017 positive regulation of locomotion GO:0044057 regulation of system process GO:0045137 development of primary sexual characteristics GO:0045665 negative regulation of neuron differentiation GO:0045926 negative regulation of growth GO:0046546 development of primary male sexual characteristics GO:0046661 male sex differentiation GO:0048483 autonomic nervous system development GO:0048485 sympathetic nervous system development GO:0048486 parasympathetic nervous system development GO:0048532 anatomical structure arrangement GO:0048588 developmental cell growth GO:0048608 reproductive structure development GO:0048638 regulation of developmental growth GO:0048640 negative regulation of developmental growth GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048675 axon extension GO:0048732 gland development GO:0048762 mesenchymal cell differentiation GO:0048813 dendrite morphogenesis GO:0048841 regulation of axon extension involved in axon guidance GO:0048843 negative regulation of axon extension involved in axon guidance GO:0048846 axon extension involved in axon guidance GO:0048863 stem cell differentiation GO:0048864 stem cell development GO:0048880 sensory system development GO:0050768 negative regulation of neurogenesis GO:0050769 positive regulation of neurogenesis GO:0050770 regulation of axonogenesis GO:0050771 negative regulation of axonogenesis GO:0050919 negative chemotaxis GO:0050920 regulation of chemotaxis GO:0050922 negative regulation of chemotaxis GO:0051271 negative regulation of cellular component movement GO:0051272 positive regulation of cellular component movement GO:0051961 negative regulation of nervous system development GO:0051962 positive regulation of nervous system development GO:0060047 heart contraction GO:0060384 innervation GO:0060385 axonogenesis involved in innervation GO:0060445 branching involved in salivary gland morphogenesis GO:0060485 mesenchyme development GO:0060560 developmental growth involved in morphogenesis GO:0060600 dichotomous subdivision of an epithelial terminal unit GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching GO:0061138 morphogenesis of a branching epithelium GO:0061387 regulation of extent of cell growth GO:0061458 reproductive system development GO:0061548 ganglion development GO:0061549 sympathetic ganglion development GO:0061550 cranial ganglion development GO:0061551 trigeminal ganglion development GO:0061564 axon development GO:0071526 semaphorin-plexin signaling pathway GO:0090066 regulation of anatomical structure size GO:0090130 tissue migration GO:0090132 epithelium migration GO:0097485 neuron projection guidance GO:0097490 sympathetic neuron projection extension GO:0097491 sympathetic neuron projection guidance GO:1901166 neural crest cell migration involved in autonomic nervous system development GO:1902284 neuron projection extension involved in neuron projection guidance GO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance GO:1902287 semaphorin-plexin signaling pathway involved in axon guidance GO:1902667 regulation of axon guidance GO:1902668 negative regulation of axon guidance GO:1903045 neural crest cell migration involved in sympathetic nervous system development GO:1903375 facioacoustic ganglion development GO:1903522 regulation of blood circulation GO:1990138 neuron projection extension GO:2000018 regulation of male gonad development GO:2000020 positive regulation of male gonad development GO:2000146 negative regulation of cell motility GO:2000147 positive regulation of cell motility GO:2000241 regulation of reproductive process GO:2000243 positive regulation of reproductive process GO:2001222 regulation of neuron migration GO:2001224 positive regulation of neuron migration |
Molecular Function |
GO:0030215 semaphorin receptor binding GO:0038191 neuropilin binding GO:0045499 chemorepellent activity |
Cellular Component |
GO:0030424 axon GO:0030425 dendrite |
KEGG |
hsa04360 Axon guidance |
Reactome |
R-HSA-422475: Axon guidance R-HSA-399956: CRMPs in Sema3A signaling R-HSA-1266738: Developmental Biology R-HSA-399955: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399954: Sema3A PAK dependent Axon repulsion R-HSA-373755: Semaphorin interactions |
Summary | |
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Symbol | SEMA3A |
Name | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A |
Aliases | SemD; coll-1; Hsema-I; sema III; SEMAD; COLL1; HH16; Hsema-III; SEMAIII; collapsin 1; semaphorin D; semaphor ...... |
Chromosomal Location | 7p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SEMA3A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between SEMA3A and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | SEMA3A |
Name | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A |
Aliases | SemD; coll-1; Hsema-I; sema III; SEMAD; COLL1; HH16; Hsema-III; SEMAIII; collapsin 1; semaphorin D; semaphor ...... |
Chromosomal Location | 7p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SEMA3A in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SEMA3A |
Name | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A |
Aliases | SemD; coll-1; Hsema-I; sema III; SEMAD; COLL1; HH16; Hsema-III; SEMAIII; collapsin 1; semaphorin D; semaphor ...... |
Chromosomal Location | 7p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SEMA3A in various data sets.
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Points in the above scatter plot represent the mutation difference of SEMA3A in various data sets.
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Summary | |
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Symbol | SEMA3A |
Name | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A |
Aliases | SemD; coll-1; Hsema-I; sema III; SEMAD; COLL1; HH16; Hsema-III; SEMAIII; collapsin 1; semaphorin D; semaphor ...... |
Chromosomal Location | 7p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SEMA3A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | SEMA3A |
Name | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A |
Aliases | SemD; coll-1; Hsema-I; sema III; SEMAD; COLL1; HH16; Hsema-III; SEMAIII; collapsin 1; semaphorin D; semaphor ...... |
Chromosomal Location | 7p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SEMA3A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SEMA3A. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SEMA3A |
Name | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A |
Aliases | SemD; coll-1; Hsema-I; sema III; SEMAD; COLL1; HH16; Hsema-III; SEMAIII; collapsin 1; semaphorin D; semaphor ...... |
Chromosomal Location | 7p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SEMA3A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | SEMA3A |
Name | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A |
Aliases | SemD; coll-1; Hsema-I; sema III; SEMAD; COLL1; HH16; Hsema-III; SEMAIII; collapsin 1; semaphorin D; semaphor ...... |
Chromosomal Location | 7p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SEMA3A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | SEMA3A |
Name | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A |
Aliases | SemD; coll-1; Hsema-I; sema III; SEMAD; COLL1; HH16; Hsema-III; SEMAIII; collapsin 1; semaphorin D; semaphor ...... |
Chromosomal Location | 7p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SEMA3A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | SEMA3A |
Name | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A |
Aliases | SemD; coll-1; Hsema-I; sema III; SEMAD; COLL1; HH16; Hsema-III; SEMAIII; collapsin 1; semaphorin D; semaphor ...... |
Chromosomal Location | 7p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SEMA3A collected from DrugBank database. |
There is no record. |