Summary | |
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Symbol | SEMA6B |
Name | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B |
Aliases | semaZ; SEMA-VIB; SEM-SEMA-Y; Sema VIb; semaphorin Z; semaphorin VIB; SEMAN; semaphorin-6Ba; Sema Z; Semaphor ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Single-pass type I membrane protein. |
Domain |
PF01437 Plexin repeat PF01403 Sema domain |
Function |
May play a role in both peripheral and central nervous system development. |
Biological Process |
GO:0001558 regulation of cell growth GO:0001667 ameboidal-type cell migration GO:0001755 neural crest cell migration GO:0007409 axonogenesis GO:0007411 axon guidance GO:0008361 regulation of cell size GO:0010721 negative regulation of cell development GO:0010769 regulation of cell morphogenesis involved in differentiation GO:0010771 negative regulation of cell morphogenesis involved in differentiation GO:0010975 regulation of neuron projection development GO:0010977 negative regulation of neuron projection development GO:0014031 mesenchymal cell development GO:0014032 neural crest cell development GO:0014033 neural crest cell differentiation GO:0016049 cell growth GO:0022604 regulation of cell morphogenesis GO:0030308 negative regulation of cell growth GO:0030335 positive regulation of cell migration GO:0030516 regulation of axon extension GO:0030517 negative regulation of axon extension GO:0031345 negative regulation of cell projection organization GO:0032102 negative regulation of response to external stimulus GO:0032535 regulation of cellular component size GO:0040013 negative regulation of locomotion GO:0040017 positive regulation of locomotion GO:0045665 negative regulation of neuron differentiation GO:0045926 negative regulation of growth GO:0048588 developmental cell growth GO:0048638 regulation of developmental growth GO:0048640 negative regulation of developmental growth GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048675 axon extension GO:0048762 mesenchymal cell differentiation GO:0048841 regulation of axon extension involved in axon guidance GO:0048843 negative regulation of axon extension involved in axon guidance GO:0048846 axon extension involved in axon guidance GO:0048863 stem cell differentiation GO:0048864 stem cell development GO:0050768 negative regulation of neurogenesis GO:0050770 regulation of axonogenesis GO:0050771 negative regulation of axonogenesis GO:0050919 negative chemotaxis GO:0050920 regulation of chemotaxis GO:0050922 negative regulation of chemotaxis GO:0051271 negative regulation of cellular component movement GO:0051272 positive regulation of cellular component movement GO:0051961 negative regulation of nervous system development GO:0060485 mesenchyme development GO:0060560 developmental growth involved in morphogenesis GO:0061387 regulation of extent of cell growth GO:0061564 axon development GO:0071526 semaphorin-plexin signaling pathway GO:0090066 regulation of anatomical structure size GO:0097485 neuron projection guidance GO:1902284 neuron projection extension involved in neuron projection guidance GO:1902667 regulation of axon guidance GO:1902668 negative regulation of axon guidance GO:1990138 neuron projection extension GO:2000147 positive regulation of cell motility |
Molecular Function |
GO:0030215 semaphorin receptor binding GO:0045499 chemorepellent activity |
Cellular Component | - |
KEGG |
hsa04360 Axon guidance |
Reactome | - |
Summary | |
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Symbol | SEMA6B |
Name | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B |
Aliases | semaZ; SEMA-VIB; SEM-SEMA-Y; Sema VIb; semaphorin Z; semaphorin VIB; SEMAN; semaphorin-6Ba; Sema Z; Semaphor ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SEMA6B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | SEMA6B |
Name | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B |
Aliases | semaZ; SEMA-VIB; SEM-SEMA-Y; Sema VIb; semaphorin Z; semaphorin VIB; SEMAN; semaphorin-6Ba; Sema Z; Semaphor ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SEMA6B in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SEMA6B |
Name | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B |
Aliases | semaZ; SEMA-VIB; SEM-SEMA-Y; Sema VIb; semaphorin Z; semaphorin VIB; SEMAN; semaphorin-6Ba; Sema Z; Semaphor ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SEMA6B in various data sets.
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Points in the above scatter plot represent the mutation difference of SEMA6B in various data sets.
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Summary | |
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Symbol | SEMA6B |
Name | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B |
Aliases | semaZ; SEMA-VIB; SEM-SEMA-Y; Sema VIb; semaphorin Z; semaphorin VIB; SEMAN; semaphorin-6Ba; Sema Z; Semaphor ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SEMA6B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | SEMA6B |
Name | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B |
Aliases | semaZ; SEMA-VIB; SEM-SEMA-Y; Sema VIb; semaphorin Z; semaphorin VIB; SEMAN; semaphorin-6Ba; Sema Z; Semaphor ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SEMA6B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SEMA6B. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SEMA6B |
Name | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B |
Aliases | semaZ; SEMA-VIB; SEM-SEMA-Y; Sema VIb; semaphorin Z; semaphorin VIB; SEMAN; semaphorin-6Ba; Sema Z; Semaphor ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SEMA6B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | SEMA6B |
Name | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B |
Aliases | semaZ; SEMA-VIB; SEM-SEMA-Y; Sema VIb; semaphorin Z; semaphorin VIB; SEMAN; semaphorin-6Ba; Sema Z; Semaphor ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SEMA6B expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | SEMA6B |
Name | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B |
Aliases | semaZ; SEMA-VIB; SEM-SEMA-Y; Sema VIb; semaphorin Z; semaphorin VIB; SEMAN; semaphorin-6Ba; Sema Z; Semaphor ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SEMA6B and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | SEMA6B |
Name | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B |
Aliases | semaZ; SEMA-VIB; SEM-SEMA-Y; Sema VIb; semaphorin Z; semaphorin VIB; SEMAN; semaphorin-6Ba; Sema Z; Semaphor ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SEMA6B collected from DrugBank database. |
There is no record. |